Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
PRKACA	HAND1	Ser109	KERRRTEsINSAFAE	phosphorylation down-regulates activity	14636580	SIGNOR-249989
PRKCA	HAND1	Ser98	RLGRRKGsGPKKERR	phosphorylation unknown	14636580	SIGNOR-249243
PRKCA	HAND1	Ser109	KERRRTEsINSAFAE	phosphorylation unknown	14636580	SIGNOR-249242
PRKCA	HAND1	Thr107	PKKERRRtESINSAF	phosphorylation unknown	14636580	SIGNOR-249244
PRKACA	HAND1	Ser98	RLGRRKGsGPKKERR	phosphorylation unknown	14636580	SIGNOR-249990
PRKACA	HAND1	Thr107	PKKERRRtESINSAF	phosphorylation down-regulates activity	14636580	SIGNOR-249991

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
PRKACA	phosphorylation up-regulates →	HAND1 PSer109	phosphorylation down-regulates ⊣	HAND1	14636580	SIGNOR-249989
PRKCA	phosphorylation up-regulates →	HAND1 PSer98	phosphorylation down-regulates ⊣	HAND1	14636580	SIGNOR-249243
PRKCA	phosphorylation up-regulates →	HAND1 PSer109	phosphorylation down-regulates ⊣	HAND1	14636580	SIGNOR-249242
PRKCA	phosphorylation up-regulates →	HAND1 PThr107	phosphorylation down-regulates ⊣	HAND1	14636580	SIGNOR-249244
PRKACA	phosphorylation up-regulates →	HAND1 PSer98	phosphorylation down-regulates ⊣	HAND1	14636580	SIGNOR-249990
PRKACA	phosphorylation up-regulates →	HAND1 PThr107	phosphorylation down-regulates ⊣	HAND1	14636580	SIGNOR-249991

Regulator	Mechanism/Effect	Target	SIGNOR-ID
PRKACA	phosphorylation → down-regulates activity	HAND1	SIGNOR-249989
PRKCA	phosphorylation → unknown	HAND1	SIGNOR-249243
PRKCA	phosphorylation → unknown	HAND1	SIGNOR-249242
PRKCA	phosphorylation → unknown	HAND1	SIGNOR-249244
PRKACA	phosphorylation → unknown	HAND1	SIGNOR-249990
PRKACA	phosphorylation → down-regulates activity	HAND1	SIGNOR-249991