| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | HAND1 | Thr107 | PKKERRRtESINSAF | phosphorylation down-regulates activity | 14636580 | SIGNOR-249991 |
| PRKCA | HAND1 | Thr107 | PKKERRRtESINSAF | phosphorylation unknown | 14636580 | SIGNOR-249244 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | phosphorylation up-regulates → | HAND1 PThr107 | phosphorylation down-regulates ⊣ | HAND1 | 14636580 | SIGNOR-249991 |
| PRKCA | phosphorylation up-regulates → | HAND1 PThr107 | phosphorylation down-regulates ⊣ | HAND1 | 14636580 | SIGNOR-249244 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKACA | phosphorylation → down-regulates activity | HAND1 | SIGNOR-249991 |
| PRKCA | phosphorylation → unknown | HAND1 | SIGNOR-249244 |
