| Name | CHEK2 |
| ID | O96017 |
| Role | kinase |
| Enzymatic Domains |
FHA 113-175 PROSITE-ProRule
Protein kinase 220-486 PROSITE-ProRule |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK2 | CHEK2 | Ser379 | SKILGETsLMRTLCG | phosphorylation up-regulates activity | 18644861 | SIGNOR-179537 |
| CHEK2 | NEK6 | – | phosphorylation down-regulates activity | 18728393 | SIGNOR-279404 | |
| CHEK2 | TRIM32 | Ser55 | LEKLLASsINGVRCP | phosphorylation up-regulates activity | 37943659 | SIGNOR-277804 |
| CHEK2 | TP53 | Ser378 | SKKGQSTsRHKKLMF | phosphorylation up-regulates quantity by stabilization | 10710310 | SIGNOR-75641 |
| CHEK2 | E2F1 | Ser364 | PLLSRMGsLRAPVDE | phosphorylation up-regulates quantity by stabilization | 12717439 | SIGNOR-100898 |
| CHEK2 | CDC25A | Ser124 | PALKRSHsDSLDHDI | phosphorylation down-regulates quantity by destabilization | 11298456 | SIGNOR-106808 |
| CHEK2 | TBPL1 | – | phosphorylation down-regulates activity | 19375317 | SIGNOR-280227 | |
| CHEK2 | BECN1 | Ser90 | IPPARMMsTESANSF | phosphorylation up-regulates activity | 32187724 | SIGNOR-264557 |
| CHEK2 | EXO1 | – | phosphorylation down-regulates activity | 20690856 | SIGNOR-279028 | |
| CHEK2 | AATF | Ser143 | SKKSRSHsAKTPGFS | phosphorylation up-regulates quantity by stabilization | 17157788 | SIGNOR-264416 |
| CHEK2 | TRIM28 | Ser473 | SGVKRSRsGEGEVSG | phosphorylation down-regulates activity | 26158765 | SIGNOR-279730 |
| CHEK2 | TP53 | Thr18 | EPPLSQEtFSDLWKL | phosphorylation up-regulates quantity by stabilization | 10710310 | SIGNOR-75645 |
| CHEK2 | ELAVL1 | Ser88 | LNGLRLQsKTIKVSY | phosphorylation down-regulates activity | 21745814 | SIGNOR-278163 |
| CHEK2 | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates quantity by stabilization | 10801407 | SIGNOR-77144 |
| CHEK2 | TP53 | Ser378 | SKKGQSTsRHKKLMF | phosphorylation up-regulates quantity by stabilization | 17339337 | SIGNOR-153479 |
| CHEK2 | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates quantity by stabilization | 17339337 | SIGNOR-153463 |
| CHEK2 | BRCA1 | Ser988 | PPLFPIKsFVKTKCK | phosphorylation up-regulates | 14701743 | SIGNOR-120575 |
| CHEK2 | TP53 | Ser37 | NVLSPLPsQAMDDLM | phosphorylation up-regulates quantity by stabilization | 10656682 | SIGNOR-74831 |
| CHEK2 | CDC25A | Ser293 | GSTKRRKsMSGASPK | phosphorylation down-regulates quantity | 12676583 | SIGNOR-260836 |
| CHEK2 | AATF | Ser510 | KKVDRKAsKGRKLRF | phosphorylation up-regulates quantity by stabilization | 17157788 | SIGNOR-264418 |
| CHEK2 | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates quantity by stabilization | 10673501 | SIGNOR-75009 |
| CHEK2 | MDM4 | Ser367 | PDCRRTIsAPVVRPK | phosphorylation down-regulates quantity by destabilization | 18356162 | SIGNOR-178071 |
| CHEK2 | TTK | Thr288 | SPDCDVKtDDSVVPC | phosphorylation up-regulates | 19151762 | SIGNOR-242665 |
| CHEK2 | MPEG1 | Thr288 | VPFYPGItLQAWQQG | phosphorylation up-regulates activity | 24798733 | SIGNOR-279160 |
| CHEK2 | TP53 | Ser378 | SKKGQSTsRHKKLMF | phosphorylation up-regulates quantity by stabilization | 15659650 | SIGNOR-74835 |
| CHEK2 | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates quantity by stabilization | 10710310 | SIGNOR-75629 |
| CHEK2 | BECN1 | Ser93 | ARMMSTEsANSFTLI | phosphorylation up-regulates activity | 32187724 | SIGNOR-264556 |
| CHEK2 | AATF | Ser477 | ELIERKTsSLDPNDQ | phosphorylation up-regulates quantity by stabilization | 17157788 | SIGNOR-264417 |
| CHEK2 | CDC25C | Ser216 | SGLYRSPsMPENLNR | phosphorylation down-regulates activity | 12835754 | SIGNOR-102779 |
| CHEK2 | CHEK2 | Thr387 | LMRTLCGtPTYLAPE | phosphorylation up-regulates activity | 11901158 | SIGNOR-116131 |
| CHEK2 | CDC25A | Ser178 | LFTQRQNsAPARMLS | phosphorylation down-regulates quantity by destabilization | 12676583 | SIGNOR-99725 |
| CHEK2 | TRIM32 | Ser55 | LEKLLASsINGVRCP | phosphorylation up-regulates activity | 37943659 | SIGNOR-277790 |
| CHEK2 | CDC25A | Ser279 | VLKRPERsQEESPPG | phosphorylation down-regulates quantity by destabilization | 12676583 | SIGNOR-99729 |
| CHEK2 | KIT | – | phosphorylation up-regulates | 22558186 | SIGNOR-197281 | |
| CHEK2 | CHEK2 | Thr383 | GETSLMRtLCGTPTY | phosphorylation up-regulates activity | 11901158 | SIGNOR-116127 |
| CHEK2 | VHL | Ser111 | GTGRRIHsYRGHLWL | phosphorylation up-regulates | 22071692 | SIGNOR-177091 |
| CHEK2 | CDC25A | Ser178 | LFTQRQNsAPARMLS | phosphorylation down-regulates quantity by destabilization | 14559997 | SIGNOR-118759 |
| CHEK2 | CHEK2 | Thr68 | SSLETVStQELYSIP | phosphorylation up-regulates activity | 11901158 | SIGNOR-116135 |
| CHEK2 | CDC25A | Ser293 | GSTKRRKsMSGASPK | phosphorylation down-regulates quantity by destabilization | 12676583 | SIGNOR-99733 |
| CHEK2 | TP53 | Ser366 | PGGSRAHsSHLKSKK | phosphorylation up-regulates quantity by stabilization | 15659650 | SIGNOR-75633 |
| CHEK2 | ELAVL1 | Thr118 | SGLPRTMtQKDVEDM | phosphorylation down-regulates activity | 21745814 | SIGNOR-278162 |
| CHEK2 | RB1 | Ser612 | MYLSPVRsPKKKGST | phosphorylation up-regulates activity | 17380128 | SIGNOR-153908 |
| CHEK2 | CHEK2 | Ser516 | PQVLAQPsTSRKRPR | phosphorylation up-regulates activity | 12855706 | SIGNOR-103544 |
| CHEK2 | TP53 | Ser37 | NVLSPLPsQAMDDLM | phosphorylation up-regulates quantity by stabilization | 15659650 | SIGNOR-153475 |
| CHEK2 | DNA2 | – | phosphorylation up-regulates activity | 22682245 | SIGNOR-279729 | |
| CHEK2 | E2F1 | Ser364 | PLLSRMGsLRAPVDE | phosphorylation up-regulates quantity by stabilization | 22558186 | SIGNOR-197278 |
| CHEK2 | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates activity | 17339337 | SIGNOR-260776 |
| CHEK2 | CDC25A | Ser124 | PALKRSHsDSLDHDI | phosphorylation down-regulates quantity by destabilization | 12676583 | SIGNOR-99721 |
| CHEK2 | CDC25A | Ser279 | VLKRPERsQEESPPG | phosphorylation down-regulates quantity | 12676583 | SIGNOR-260834 |
| CHEK2 | CDC25A | Ser124 | PALKRSHsDSLDHDI | phosphorylation down-regulates quantity | 12676583 | SIGNOR-260835 |
| CHEK2 | PPP2R5C | – | phosphorylation up-regulates | 15380617 | SIGNOR-129255 | |
| CHEK2 | TP53 | Ser37 | NVLSPLPsQAMDDLM | phosphorylation up-regulates quantity by stabilization | 10710310 | SIGNOR-75637 |
| CHEK2 | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates quantity by stabilization | 10656682 | SIGNOR-74823 |
| CHEK2 | TP53 | Ser366 | PGGSRAHsSHLKSKK | phosphorylation up-regulates quantity by stabilization | 10673501 | SIGNOR-75013 |
| CHEK2 | MAPT | Ser579 | NVKSKIGsTENLKHQ | phosphorylation down-regulates | 21215781 | SIGNOR-171026 |
| CHEK2 | ELAVL1 | Ser100 | VSYARPSsEVIKDAN | phosphorylation up-regulates activity | 21745814 | SIGNOR-278161 |
| CHEK2 | CDC5L | – | phosphorylation down-regulates activity | 32059558 | SIGNOR-279694 | |
| CHEK2 | INCENP | Ser91 | RRLSRRKsRSSQLSS | phosphorylation up-regulates activity | 33355621 | SIGNOR-279695 |
| CHEK2 | MDM4 | Ser342 | SKLTHSLsTSDITAI | phosphorylation down-regulates | 16163388 | SIGNOR-140417 |
| CHEK2 | CDC25A | Ser124 | PALKRSHsDSLDHDI | phosphorylation down-regulates quantity by destabilization | 11298456 | SIGNOR-260778 |
| CHEK2 | AURKB | Ser331 | HPWVRANsRRVLPPS | phosphorylation up-regulates activity | 24798733 | SIGNOR-278906 |
| CHEK2 | CDC25A | Ser178 | LFTQRQNsAPARMLS | phosphorylation down-regulates quantity | 12676583 | SIGNOR-260833 |
| CHEK2 | TP53 | Thr18 | EPPLSQEtFSDLWKL | phosphorylation up-regulates quantity by stabilization | 10673501 | SIGNOR-75025 |
| CHEK2 | BLM | Thr182 | SHFVRVStAQKSKKG | phosphorylation down-regulates quantity by destabilization | 26028025 | SIGNOR-276908 |
| CHEK2 | TP53 | Thr18 | EPPLSQEtFSDLWKL | phosphorylation up-regulates quantity by stabilization | 17339337 | SIGNOR-153483 |
| CHEK2 | RASGRF1 | Ser287 | PITHDDVsSIFLNSE | phosphorylation down-regulates | 17110335 | SIGNOR-150843 |
| CHEK2 | FOXM1 | Ser376 | PLLPRVSsYLVPIQF | phosphorylation up-regulates | 17101782 | SIGNOR-150746 |
| CHEK2 | E2F1 | Ser364 | PLLSRMGsLRAPVDE | phosphorylation up-regulates activity | 12717439 | SIGNOR-260822 |
| CHEK2 | PSME3 | Ser247 | EKIKRPRsSNAETLY | phosphorylation up-regulates activity | 25361978 | SIGNOR-273611 |
| CHEK2 | SOD1 | Ser60 | DNTAGCTsAGPHFNP | phosphorylation up-regulates activity | 24647101 | SIGNOR-262794 |
| CHEK2 | TTK | Thr288 | SPDCDVKtDDSVVPC | phosphorylation unknown | 19151762 | SIGNOR-183470 |
| CHEK2 | XRCC1 | Thr284 | APTRTPAtAPVPARA | phosphorylation up-regulates | 18971944 | SIGNOR-181816 |
| CHEK2 | TP53 | Ser37 | NVLSPLPsQAMDDLM | phosphorylation up-regulates quantity by stabilization | 10673501 | SIGNOR-75017 |
| CHEK2 | TP53 | Thr18 | EPPLSQEtFSDLWKL | phosphorylation up-regulates quantity by stabilization | 10656682 | SIGNOR-74839 |
| CHEK2 | CDK11B | – | phosphorylation up-regulates activity | 23178491 | SIGNOR-279458 | |
| CHEK2 | PML | Ser117 | ESLQRRLsVYRQIVD | phosphorylation unknown | 12402044 | SIGNOR-94872 |
| CHEK2 | SOD1 | Ser99 | KDGVADVsIEDSVIS | phosphorylation up-regulates activity | 24647101 | SIGNOR-262795 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK2 | phosphorylation up-regulates → | CHEK2 PSer379 | phosphorylation up-regulates → | CHEK2 | 18644861 | SIGNOR-179537 |
| CHEK2 | phosphorylation up-regulates → | TRIM32 PSer55 | phosphorylation up-regulates → | TRIM32 | 37943659 | SIGNOR-277804 |
| CHEK2 | phosphorylation up-regulates → | TP53 PSer378 | phosphorylation up-regulates → | TP53 | 10710310 | SIGNOR-75641 |
| CHEK2 | phosphorylation up-regulates → | E2F1 PSer364 | phosphorylation up-regulates → | E2F1 | 12717439 | SIGNOR-100898 |
| CHEK2 | phosphorylation up-regulates → | CDC25A PSer124 | phosphorylation down-regulates ⊣ | CDC25A | 11298456 | SIGNOR-106808 |
| CHEK2 | phosphorylation up-regulates → | BECN1 PSer90 | phosphorylation up-regulates → | BECN1 | 32187724 | SIGNOR-264557 |
| CHEK2 | phosphorylation up-regulates → | AATF PSer143 | phosphorylation up-regulates → | AATF | 17157788 | SIGNOR-264416 |
| CHEK2 | phosphorylation up-regulates → | TRIM28 PSer473 | phosphorylation down-regulates ⊣ | TRIM28 | 26158765 | SIGNOR-279730 |
| CHEK2 | phosphorylation up-regulates → | TP53 PThr18 | phosphorylation up-regulates → | TP53 | 10710310 | SIGNOR-75645 |
| CHEK2 | phosphorylation up-regulates → | ELAVL1 PSer88 | phosphorylation down-regulates ⊣ | ELAVL1 | 21745814 | SIGNOR-278163 |
| CHEK2 | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 10801407 | SIGNOR-77144 |
| CHEK2 | phosphorylation up-regulates → | TP53 PSer378 | phosphorylation up-regulates → | TP53 | 17339337 | SIGNOR-153479 |
| CHEK2 | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 17339337 | SIGNOR-153463 |
| CHEK2 | phosphorylation up-regulates → | BRCA1 PSer988 | phosphorylation up-regulates → | BRCA1 | 14701743 | SIGNOR-120575 |
| CHEK2 | phosphorylation up-regulates → | TP53 PSer37 | phosphorylation up-regulates → | TP53 | 10656682 | SIGNOR-74831 |
| CHEK2 | phosphorylation up-regulates → | CDC25A PSer293 | phosphorylation down-regulates ⊣ | CDC25A | 12676583 | SIGNOR-260836 |
| CHEK2 | phosphorylation up-regulates → | AATF PSer510 | phosphorylation up-regulates → | AATF | 17157788 | SIGNOR-264418 |
| CHEK2 | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 10673501 | SIGNOR-75009 |
| CHEK2 | phosphorylation up-regulates → | MDM4 PSer367 | phosphorylation down-regulates ⊣ | MDM4 | 18356162 | SIGNOR-178071 |
| CHEK2 | phosphorylation up-regulates → | TTK PThr288 | phosphorylation up-regulates → | TTK | 19151762 | SIGNOR-242665 |
| CHEK2 | phosphorylation up-regulates → | MPEG1 PThr288 | phosphorylation up-regulates → | MPEG1 | 24798733 | SIGNOR-279160 |
| CHEK2 | phosphorylation up-regulates → | TP53 PSer378 | phosphorylation up-regulates → | TP53 | 15659650 | SIGNOR-74835 |
| CHEK2 | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 10710310 | SIGNOR-75629 |
| CHEK2 | phosphorylation up-regulates → | BECN1 PSer93 | phosphorylation up-regulates → | BECN1 | 32187724 | SIGNOR-264556 |
| CHEK2 | phosphorylation up-regulates → | AATF PSer477 | phosphorylation up-regulates → | AATF | 17157788 | SIGNOR-264417 |
| CHEK2 | phosphorylation up-regulates → | CDC25C PSer216 | phosphorylation down-regulates ⊣ | CDC25C | 12835754 | SIGNOR-102779 |
| CHEK2 | phosphorylation up-regulates → | CHEK2 PThr387 | phosphorylation up-regulates → | CHEK2 | 11901158 | SIGNOR-116131 |
| CHEK2 | phosphorylation up-regulates → | CDC25A PSer178 | phosphorylation down-regulates ⊣ | CDC25A | 12676583 | SIGNOR-99725 |
| CHEK2 | phosphorylation up-regulates → | TRIM32 PSer55 | phosphorylation up-regulates → | TRIM32 | 37943659 | SIGNOR-277790 |
| CHEK2 | phosphorylation up-regulates → | CDC25A PSer279 | phosphorylation down-regulates ⊣ | CDC25A | 12676583 | SIGNOR-99729 |
| CHEK2 | phosphorylation up-regulates → | CHEK2 PThr383 | phosphorylation up-regulates → | CHEK2 | 11901158 | SIGNOR-116127 |
| CHEK2 | phosphorylation up-regulates → | VHL PSer111 | phosphorylation up-regulates → | VHL | 22071692 | SIGNOR-177091 |
| CHEK2 | phosphorylation up-regulates → | CDC25A PSer178 | phosphorylation down-regulates ⊣ | CDC25A | 14559997 | SIGNOR-118759 |
| CHEK2 | phosphorylation up-regulates → | CHEK2 PThr68 | phosphorylation up-regulates → | CHEK2 | 11901158 | SIGNOR-116135 |
| CHEK2 | phosphorylation up-regulates → | CDC25A PSer293 | phosphorylation down-regulates ⊣ | CDC25A | 12676583 | SIGNOR-99733 |
| CHEK2 | phosphorylation up-regulates → | TP53 PSer366 | phosphorylation up-regulates → | TP53 | 15659650 | SIGNOR-75633 |
| CHEK2 | phosphorylation up-regulates → | ELAVL1 PThr118 | phosphorylation down-regulates ⊣ | ELAVL1 | 21745814 | SIGNOR-278162 |
| CHEK2 | phosphorylation up-regulates → | RB1 PSer612 | phosphorylation up-regulates → | RB1 | 17380128 | SIGNOR-153908 |
| CHEK2 | phosphorylation up-regulates → | CHEK2 PSer516 | phosphorylation up-regulates → | CHEK2 | 12855706 | SIGNOR-103544 |
| CHEK2 | phosphorylation up-regulates → | TP53 PSer37 | phosphorylation up-regulates → | TP53 | 15659650 | SIGNOR-153475 |
| CHEK2 | phosphorylation up-regulates → | E2F1 PSer364 | phosphorylation up-regulates → | E2F1 | 22558186 | SIGNOR-197278 |
| CHEK2 | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 17339337 | SIGNOR-260776 |
| CHEK2 | phosphorylation up-regulates → | CDC25A PSer124 | phosphorylation down-regulates ⊣ | CDC25A | 12676583 | SIGNOR-99721 |
| CHEK2 | phosphorylation up-regulates → | CDC25A PSer279 | phosphorylation down-regulates ⊣ | CDC25A | 12676583 | SIGNOR-260834 |
| CHEK2 | phosphorylation up-regulates → | CDC25A PSer124 | phosphorylation down-regulates ⊣ | CDC25A | 12676583 | SIGNOR-260835 |
| CHEK2 | phosphorylation up-regulates → | TP53 PSer37 | phosphorylation up-regulates → | TP53 | 10710310 | SIGNOR-75637 |
| CHEK2 | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 10656682 | SIGNOR-74823 |
| CHEK2 | phosphorylation up-regulates → | TP53 PSer366 | phosphorylation up-regulates → | TP53 | 10673501 | SIGNOR-75013 |
| CHEK2 | phosphorylation up-regulates → | MAPT PSer579 | phosphorylation down-regulates ⊣ | MAPT | 21215781 | SIGNOR-171026 |
| CHEK2 | phosphorylation up-regulates → | ELAVL1 PSer100 | phosphorylation up-regulates → | ELAVL1 | 21745814 | SIGNOR-278161 |
| CHEK2 | phosphorylation up-regulates → | INCENP PSer91 | phosphorylation up-regulates → | INCENP | 33355621 | SIGNOR-279695 |
| CHEK2 | phosphorylation up-regulates → | MDM4 PSer342 | phosphorylation down-regulates ⊣ | MDM4 | 16163388 | SIGNOR-140417 |
| CHEK2 | phosphorylation up-regulates → | CDC25A PSer124 | phosphorylation down-regulates ⊣ | CDC25A | 11298456 | SIGNOR-260778 |
| CHEK2 | phosphorylation up-regulates → | AURKB PSer331 | phosphorylation up-regulates → | AURKB | 24798733 | SIGNOR-278906 |
| CHEK2 | phosphorylation up-regulates → | CDC25A PSer178 | phosphorylation down-regulates ⊣ | CDC25A | 12676583 | SIGNOR-260833 |
| CHEK2 | phosphorylation up-regulates → | TP53 PThr18 | phosphorylation up-regulates → | TP53 | 10673501 | SIGNOR-75025 |
| CHEK2 | phosphorylation up-regulates → | BLM PThr182 | phosphorylation down-regulates ⊣ | BLM | 26028025 | SIGNOR-276908 |
| CHEK2 | phosphorylation up-regulates → | TP53 PThr18 | phosphorylation up-regulates → | TP53 | 17339337 | SIGNOR-153483 |
| CHEK2 | phosphorylation up-regulates → | RASGRF1 PSer287 | phosphorylation down-regulates ⊣ | RASGRF1 | 17110335 | SIGNOR-150843 |
| CHEK2 | phosphorylation up-regulates → | FOXM1 PSer376 | phosphorylation up-regulates → | FOXM1 | 17101782 | SIGNOR-150746 |
| CHEK2 | phosphorylation up-regulates → | E2F1 PSer364 | phosphorylation up-regulates → | E2F1 | 12717439 | SIGNOR-260822 |
| CHEK2 | phosphorylation up-regulates → | PSME3 PSer247 | phosphorylation up-regulates → | PSME3 | 25361978 | SIGNOR-273611 |
| CHEK2 | phosphorylation up-regulates → | SOD1 PSer60 | phosphorylation up-regulates → | SOD1 | 24647101 | SIGNOR-262794 |
| CHEK2 | phosphorylation up-regulates → | TTK PThr288 | phosphorylation down-regulates ⊣ | TTK | 19151762 | SIGNOR-183470 |
| CHEK2 | phosphorylation up-regulates → | XRCC1 PThr284 | phosphorylation up-regulates → | XRCC1 | 18971944 | SIGNOR-181816 |
| CHEK2 | phosphorylation up-regulates → | TP53 PSer37 | phosphorylation up-regulates → | TP53 | 10673501 | SIGNOR-75017 |
| CHEK2 | phosphorylation up-regulates → | TP53 PThr18 | phosphorylation up-regulates → | TP53 | 10656682 | SIGNOR-74839 |
| CHEK2 | phosphorylation up-regulates → | PML PSer117 | phosphorylation down-regulates ⊣ | PML | 12402044 | SIGNOR-94872 |
| CHEK2 | phosphorylation up-regulates → | SOD1 PSer99 | phosphorylation up-regulates → | SOD1 | 24647101 | SIGNOR-262795 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CHEK2 | phosphorylation → up-regulates activity | CHEK2 | SIGNOR-179537 |
| CHEK2 | phosphorylation → down-regulates activity | NEK6 | SIGNOR-279404 |
| CHEK2 | phosphorylation → up-regulates activity | TRIM32 | SIGNOR-277804 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-75641 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | E2F1 | SIGNOR-100898 |
| CHEK2 | phosphorylation down-regulates quantity by destabilization | CDC25A | SIGNOR-106808 |
| CHEK2 | phosphorylation → down-regulates activity | TBPL1 | SIGNOR-280227 |
| CHEK2 | phosphorylation → up-regulates activity | BECN1 | SIGNOR-264557 |
| CHEK2 | phosphorylation → down-regulates activity | EXO1 | SIGNOR-279028 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | AATF | SIGNOR-264416 |
| CHEK2 | phosphorylation → down-regulates activity | TRIM28 | SIGNOR-279730 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-75645 |
| CHEK2 | phosphorylation → down-regulates activity | ELAVL1 | SIGNOR-278163 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-77144 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-153479 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-153463 |
| CHEK2 | phosphorylation → up-regulates | BRCA1 | SIGNOR-120575 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-74831 |
| CHEK2 | phosphorylation → down-regulates quantity | CDC25A | SIGNOR-260836 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | AATF | SIGNOR-264418 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-75009 |
| CHEK2 | phosphorylation down-regulates quantity by destabilization | MDM4 | SIGNOR-178071 |
| CHEK2 | phosphorylation → up-regulates | TTK | SIGNOR-242665 |
| CHEK2 | phosphorylation → up-regulates activity | MPEG1 | SIGNOR-279160 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-74835 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-75629 |
| CHEK2 | phosphorylation → up-regulates activity | BECN1 | SIGNOR-264556 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | AATF | SIGNOR-264417 |
| CHEK2 | phosphorylation → down-regulates activity | CDC25C | SIGNOR-102779 |
| CHEK2 | phosphorylation → up-regulates activity | CHEK2 | SIGNOR-116131 |
| CHEK2 | phosphorylation down-regulates quantity by destabilization | CDC25A | SIGNOR-99725 |
| CHEK2 | phosphorylation → up-regulates activity | TRIM32 | SIGNOR-277790 |
| CHEK2 | phosphorylation down-regulates quantity by destabilization | CDC25A | SIGNOR-99729 |
| CHEK2 | phosphorylation → up-regulates | KIT | SIGNOR-197281 |
| CHEK2 | phosphorylation → up-regulates activity | CHEK2 | SIGNOR-116127 |
| CHEK2 | phosphorylation → up-regulates | VHL | SIGNOR-177091 |
| CHEK2 | phosphorylation down-regulates quantity by destabilization | CDC25A | SIGNOR-118759 |
| CHEK2 | phosphorylation → up-regulates activity | CHEK2 | SIGNOR-116135 |
| CHEK2 | phosphorylation down-regulates quantity by destabilization | CDC25A | SIGNOR-99733 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-75633 |
| CHEK2 | phosphorylation → down-regulates activity | ELAVL1 | SIGNOR-278162 |
| CHEK2 | phosphorylation → up-regulates activity | RB1 | SIGNOR-153908 |
| CHEK2 | phosphorylation → up-regulates activity | CHEK2 | SIGNOR-103544 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-153475 |
| CHEK2 | phosphorylation → up-regulates activity | DNA2 | SIGNOR-279729 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | E2F1 | SIGNOR-197278 |
| CHEK2 | phosphorylation → up-regulates activity | TP53 | SIGNOR-260776 |
| CHEK2 | phosphorylation down-regulates quantity by destabilization | CDC25A | SIGNOR-99721 |
| CHEK2 | phosphorylation → down-regulates quantity | CDC25A | SIGNOR-260834 |
| CHEK2 | phosphorylation → down-regulates quantity | CDC25A | SIGNOR-260835 |
| CHEK2 | phosphorylation → up-regulates | PPP2R5C | SIGNOR-129255 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-75637 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-74823 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-75013 |
| CHEK2 | phosphorylation down-regulates | MAPT | SIGNOR-171026 |
| CHEK2 | phosphorylation → up-regulates activity | ELAVL1 | SIGNOR-278161 |
| CHEK2 | phosphorylation → down-regulates activity | CDC5L | SIGNOR-279694 |
| CHEK2 | phosphorylation → up-regulates activity | INCENP | SIGNOR-279695 |
| CHEK2 | phosphorylation down-regulates | MDM4 | SIGNOR-140417 |
| CHEK2 | phosphorylation down-regulates quantity by destabilization | CDC25A | SIGNOR-260778 |
| CHEK2 | phosphorylation → up-regulates activity | AURKB | SIGNOR-278906 |
| CHEK2 | phosphorylation → down-regulates quantity | CDC25A | SIGNOR-260833 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-75025 |
| CHEK2 | phosphorylation down-regulates quantity by destabilization | BLM | SIGNOR-276908 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-153483 |
| CHEK2 | phosphorylation down-regulates | RASGRF1 | SIGNOR-150843 |
| CHEK2 | phosphorylation → up-regulates | FOXM1 | SIGNOR-150746 |
| CHEK2 | phosphorylation → up-regulates activity | E2F1 | SIGNOR-260822 |
| CHEK2 | phosphorylation → up-regulates activity | PSME3 | SIGNOR-273611 |
| CHEK2 | phosphorylation → up-regulates activity | SOD1 | SIGNOR-262794 |
| CHEK2 | phosphorylation → unknown | TTK | SIGNOR-183470 |
| CHEK2 | phosphorylation → up-regulates | XRCC1 | SIGNOR-181816 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-75017 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-74839 |
| CHEK2 | phosphorylation → up-regulates activity | CDK11B | SIGNOR-279458 |
| CHEK2 | phosphorylation → unknown | PML | SIGNOR-94872 |
| CHEK2 | phosphorylation → up-regulates activity | SOD1 | SIGNOR-262795 |