| Name | CHEK2 |
| ID | O96017 |
| Role | substrate |
| Enzymatic Domains |
FHA 113-175 PROSITE-ProRule
Protein kinase 220-486 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATM | CHEK2 | Thr26 | SQPHGSVtQSQGSSS | phosphorylation up-regulates activity | 12024051 | SIGNOR-87850 |
| ATM | CHEK2 | Ser28 | PHGSVTQsQGSSSQS | phosphorylation up-regulates activity | 10973490 | SIGNOR-81395 |
| PPP2CB | CHEK2 | Thr68 | SSLETVStQELYSIP | dephosphorylation up-regulates activity | 16596250 | SIGNOR-248582 |
| TTK | CHEK2 | Thr68 | SSLETVStQELYSIP | phosphorylation up-regulates | 15618221 | SIGNOR-132665 |
| PLK3 | CHEK2 | Ser73 | VSTQELYsIPEDQEP | phosphorylation up-regulates activity | 16481012 | SIGNOR-276051 |
| PPP2CA | CHEK2 | Thr68 | SSLETVStQELYSIP | dephosphorylation up-regulates activity | 16596250 | SIGNOR-248617 |
| PLK1 | CHEK2 | Thr26 | SQPHGSVtQSQGSSS | phosphorylation unknown | 12493754 | SIGNOR-249180 |
| CHEK2 | CHEK2 | Ser379 | SKILGETsLMRTLCG | phosphorylation up-regulates activity | 18644861 | SIGNOR-179537 |
| ATR | CHEK2 | Thr68 | SSLETVStQELYSIP | phosphorylation up-regulates activity | 10973490 | SIGNOR-81442 |
| ATM | CHEK2 | Ser19 | SHGSSACsQPHGSVT | phosphorylation up-regulates activity | 10973490 | SIGNOR-81391 |
| PRKDC | CHEK2 | Thr68 | SSLETVStQELYSIP | phosphorylation up-regulates | 15668230 | SIGNOR-133384 |
| PLK1 | CHEK2 | Thr68 | SSLETVStQELYSIP | phosphorylation up-regulates | 12493754 | SIGNOR-96637 |
| PPM1D | CHEK2 | Thr68 | SSLETVStQELYSIP | dephosphorylation up-regulates activity | 16311512 | SIGNOR-248318 |
| ATM | CHEK2 | Thr68 | SSLETVStQELYSIP | phosphorylation up-regulates activity | 16481012 | SIGNOR-276053 |
| ATM | CHEK2 | Ser33 | TQSQGSSsQSQGISS | phosphorylation up-regulates activity | 10973490 | SIGNOR-81399 |
| CHEK2 | CHEK2 | Thr387 | LMRTLCGtPTYLAPE | phosphorylation up-regulates activity | 11901158 | SIGNOR-116131 |
| ATM | CHEK2 | Ser35 | SQGSSSQsQGISSSS | phosphorylation up-regulates activity | 10973490 | SIGNOR-81403 |
| ATM | CHEK2 | Ser50 | TSTMPNSsQSSHSSS | phosphorylation up-regulates activity | 10973490 | SIGNOR-81407 |
| ATM | CHEK2 | Thr68 | SSLETVStQELYSIP | phosphorylation up-regulates activity | 10973490 | SIGNOR-81438 |
| PLK3 | CHEK2 | Ser62 | SSSGTLSsLETVSTQ | phosphorylation up-regulates activity | 16481012 | SIGNOR-276052 |
| CHEK2 | CHEK2 | Thr383 | GETSLMRtLCGTPTY | phosphorylation up-regulates activity | 11901158 | SIGNOR-116127 |
| CHEK2 | CHEK2 | Thr68 | SSLETVStQELYSIP | phosphorylation up-regulates activity | 11901158 | SIGNOR-116135 |
| CHEK2 | CHEK2 | Ser516 | PQVLAQPsTSRKRPR | phosphorylation up-regulates activity | 12855706 | SIGNOR-103544 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATM | phosphorylation up-regulates → | CHEK2 PThr26 | phosphorylation up-regulates → | CHEK2 | 12024051 | SIGNOR-87850 |
| ATM | phosphorylation up-regulates → | CHEK2 PSer28 | phosphorylation up-regulates → | CHEK2 | 10973490 | SIGNOR-81395 |
| PPP2CB | dephosphorylation down-regulates ⊣ | CHEK2 PThr68 | dephosphorylation down-regulates ⊣ | CHEK2 | 16596250 | SIGNOR-248582 |
| TTK | phosphorylation up-regulates → | CHEK2 PThr68 | phosphorylation up-regulates → | CHEK2 | 15618221 | SIGNOR-132665 |
| PLK3 | phosphorylation up-regulates → | CHEK2 PSer73 | phosphorylation up-regulates → | CHEK2 | 16481012 | SIGNOR-276051 |
| PPP2CA | dephosphorylation down-regulates ⊣ | CHEK2 PThr68 | dephosphorylation down-regulates ⊣ | CHEK2 | 16596250 | SIGNOR-248617 |
| PLK1 | phosphorylation up-regulates → | CHEK2 PThr26 | phosphorylation down-regulates ⊣ | CHEK2 | 12493754 | SIGNOR-249180 |
| CHEK2 | phosphorylation up-regulates → | CHEK2 PSer379 | phosphorylation up-regulates → | CHEK2 | 18644861 | SIGNOR-179537 |
| ATR | phosphorylation up-regulates → | CHEK2 PThr68 | phosphorylation up-regulates → | CHEK2 | 10973490 | SIGNOR-81442 |
| ATM | phosphorylation up-regulates → | CHEK2 PSer19 | phosphorylation up-regulates → | CHEK2 | 10973490 | SIGNOR-81391 |
| PRKDC | phosphorylation up-regulates → | CHEK2 PThr68 | phosphorylation up-regulates → | CHEK2 | 15668230 | SIGNOR-133384 |
| PLK1 | phosphorylation up-regulates → | CHEK2 PThr68 | phosphorylation up-regulates → | CHEK2 | 12493754 | SIGNOR-96637 |
| PPM1D | dephosphorylation down-regulates ⊣ | CHEK2 PThr68 | dephosphorylation down-regulates ⊣ | CHEK2 | 16311512 | SIGNOR-248318 |
| ATM | phosphorylation up-regulates → | CHEK2 PThr68 | phosphorylation up-regulates → | CHEK2 | 16481012 | SIGNOR-276053 |
| ATM | phosphorylation up-regulates → | CHEK2 PSer33 | phosphorylation up-regulates → | CHEK2 | 10973490 | SIGNOR-81399 |
| CHEK2 | phosphorylation up-regulates → | CHEK2 PThr387 | phosphorylation up-regulates → | CHEK2 | 11901158 | SIGNOR-116131 |
| ATM | phosphorylation up-regulates → | CHEK2 PSer35 | phosphorylation up-regulates → | CHEK2 | 10973490 | SIGNOR-81403 |
| ATM | phosphorylation up-regulates → | CHEK2 PSer50 | phosphorylation up-regulates → | CHEK2 | 10973490 | SIGNOR-81407 |
| ATM | phosphorylation up-regulates → | CHEK2 PThr68 | phosphorylation up-regulates → | CHEK2 | 10973490 | SIGNOR-81438 |
| PLK3 | phosphorylation up-regulates → | CHEK2 PSer62 | phosphorylation up-regulates → | CHEK2 | 16481012 | SIGNOR-276052 |
| CHEK2 | phosphorylation up-regulates → | CHEK2 PThr383 | phosphorylation up-regulates → | CHEK2 | 11901158 | SIGNOR-116127 |
| CHEK2 | phosphorylation up-regulates → | CHEK2 PThr68 | phosphorylation up-regulates → | CHEK2 | 11901158 | SIGNOR-116135 |
| CHEK2 | phosphorylation up-regulates → | CHEK2 PSer516 | phosphorylation up-regulates → | CHEK2 | 12855706 | SIGNOR-103544 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ATM | phosphorylation → up-regulates activity | CHEK2 | SIGNOR-87850 |
| ATM | phosphorylation → up-regulates activity | CHEK2 | SIGNOR-81395 |
| PPP2CB | dephosphorylation → up-regulates activity | CHEK2 | SIGNOR-248582 |
| TTK | phosphorylation → up-regulates | CHEK2 | SIGNOR-132665 |
| PLK3 | phosphorylation → up-regulates activity | CHEK2 | SIGNOR-276051 |
| PPP2CA | dephosphorylation → up-regulates activity | CHEK2 | SIGNOR-248617 |
| PLK1 | phosphorylation → unknown | CHEK2 | SIGNOR-249180 |
| CHEK2 | phosphorylation → up-regulates activity | CHEK2 | SIGNOR-179537 |
| ATR | phosphorylation → up-regulates activity | CHEK2 | SIGNOR-81442 |
| ATM | phosphorylation → up-regulates activity | CHEK2 | SIGNOR-81391 |
| PRKDC | phosphorylation → up-regulates | CHEK2 | SIGNOR-133384 |
| PLK1 | phosphorylation → up-regulates | CHEK2 | SIGNOR-96637 |
| PPM1D | dephosphorylation → up-regulates activity | CHEK2 | SIGNOR-248318 |
| ATM | phosphorylation → up-regulates activity | CHEK2 | SIGNOR-276053 |
| ATM | phosphorylation → up-regulates activity | CHEK2 | SIGNOR-81399 |
| CHEK2 | phosphorylation → up-regulates activity | CHEK2 | SIGNOR-116131 |
| ATM | phosphorylation → up-regulates activity | CHEK2 | SIGNOR-81403 |
| ATM | phosphorylation → up-regulates activity | CHEK2 | SIGNOR-81407 |
| ATM | phosphorylation → up-regulates activity | CHEK2 | SIGNOR-81438 |
| PLK3 | phosphorylation → up-regulates activity | CHEK2 | SIGNOR-276052 |
| CHEK2 | phosphorylation → up-regulates activity | CHEK2 | SIGNOR-116127 |
| CHEK2 | phosphorylation → up-regulates activity | CHEK2 | SIGNOR-116135 |
| CHEK2 | phosphorylation → up-regulates activity | CHEK2 | SIGNOR-103544 |