| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | CHEK2 | Thr26 | SQPHGSVtQSQGSSS | phosphorylation unknown | 12493754 | SIGNOR-249180 |
| ATM | CHEK2 | Thr26 | SQPHGSVtQSQGSSS | phosphorylation up-regulates activity | 12024051 | SIGNOR-87850 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | phosphorylation up-regulates → | CHEK2 PThr26 | phosphorylation down-regulates ⊣ | CHEK2 | 12493754 | SIGNOR-249180 |
| ATM | phosphorylation up-regulates → | CHEK2 PThr26 | phosphorylation up-regulates → | CHEK2 | 12024051 | SIGNOR-87850 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PLK1 | phosphorylation → unknown | CHEK2 | SIGNOR-249180 |
| ATM | phosphorylation → up-regulates activity | CHEK2 | SIGNOR-87850 |