| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATM | CHEK2 | Thr68 | SSLETVStQELYSIP | phosphorylation up-regulates activity | 10973490 | SIGNOR-81438 |
| CHEK2 | CHEK2 | Thr68 | SSLETVStQELYSIP | phosphorylation up-regulates activity | 11901158 | SIGNOR-116135 |
| PPP2CB | CHEK2 | Thr68 | SSLETVStQELYSIP | dephosphorylation up-regulates activity | 16596250 | SIGNOR-248582 |
| TTK | CHEK2 | Thr68 | SSLETVStQELYSIP | phosphorylation up-regulates | 15618221 | SIGNOR-132665 |
| PPP2CA | CHEK2 | Thr68 | SSLETVStQELYSIP | dephosphorylation up-regulates activity | 16596250 | SIGNOR-248617 |
| ATR | CHEK2 | Thr68 | SSLETVStQELYSIP | phosphorylation up-regulates activity | 10973490 | SIGNOR-81442 |
| PRKDC | CHEK2 | Thr68 | SSLETVStQELYSIP | phosphorylation up-regulates | 15668230 | SIGNOR-133384 |
| PLK1 | CHEK2 | Thr68 | SSLETVStQELYSIP | phosphorylation up-regulates | 12493754 | SIGNOR-96637 |
| PPM1D | CHEK2 | Thr68 | SSLETVStQELYSIP | dephosphorylation up-regulates activity | 16311512 | SIGNOR-248318 |
| ATM | CHEK2 | Thr68 | SSLETVStQELYSIP | phosphorylation up-regulates activity | 16481012 | SIGNOR-276053 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATM | phosphorylation up-regulates → | CHEK2 PThr68 | phosphorylation up-regulates → | CHEK2 | 10973490 | SIGNOR-81438 |
| CHEK2 | phosphorylation up-regulates → | CHEK2 PThr68 | phosphorylation up-regulates → | CHEK2 | 11901158 | SIGNOR-116135 |
| PPP2CB | dephosphorylation down-regulates ⊣ | CHEK2 PThr68 | dephosphorylation down-regulates ⊣ | CHEK2 | 16596250 | SIGNOR-248582 |
| TTK | phosphorylation up-regulates → | CHEK2 PThr68 | phosphorylation up-regulates → | CHEK2 | 15618221 | SIGNOR-132665 |
| PPP2CA | dephosphorylation down-regulates ⊣ | CHEK2 PThr68 | dephosphorylation down-regulates ⊣ | CHEK2 | 16596250 | SIGNOR-248617 |
| ATR | phosphorylation up-regulates → | CHEK2 PThr68 | phosphorylation up-regulates → | CHEK2 | 10973490 | SIGNOR-81442 |
| PRKDC | phosphorylation up-regulates → | CHEK2 PThr68 | phosphorylation up-regulates → | CHEK2 | 15668230 | SIGNOR-133384 |
| PLK1 | phosphorylation up-regulates → | CHEK2 PThr68 | phosphorylation up-regulates → | CHEK2 | 12493754 | SIGNOR-96637 |
| PPM1D | dephosphorylation down-regulates ⊣ | CHEK2 PThr68 | dephosphorylation down-regulates ⊣ | CHEK2 | 16311512 | SIGNOR-248318 |
| ATM | phosphorylation up-regulates → | CHEK2 PThr68 | phosphorylation up-regulates → | CHEK2 | 16481012 | SIGNOR-276053 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ATM | phosphorylation → up-regulates activity | CHEK2 | SIGNOR-81438 |
| CHEK2 | phosphorylation → up-regulates activity | CHEK2 | SIGNOR-116135 |
| PPP2CB | dephosphorylation → up-regulates activity | CHEK2 | SIGNOR-248582 |
| TTK | phosphorylation → up-regulates | CHEK2 | SIGNOR-132665 |
| PPP2CA | dephosphorylation → up-regulates activity | CHEK2 | SIGNOR-248617 |
| ATR | phosphorylation → up-regulates activity | CHEK2 | SIGNOR-81442 |
| PRKDC | phosphorylation → up-regulates | CHEK2 | SIGNOR-133384 |
| PLK1 | phosphorylation → up-regulates | CHEK2 | SIGNOR-96637 |
| PPM1D | dephosphorylation → up-regulates activity | CHEK2 | SIGNOR-248318 |
| ATM | phosphorylation → up-regulates activity | CHEK2 | SIGNOR-276053 |
