| Name | ABL1 |
| ID | P00519 |
| Role | substrate |
| Enzymatic Domains |
SH3 61-121 PROSITE-ProRule
SH2 127-217 PROSITE-ProRule
Protein kinase 242-493 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| STK4 | ABL1 | Thr735 | DTEWRSVtLPRDLQS | phosphorylation down-regulates | 18794806 | SIGNOR-181060 |
| PRKDC | ABL1 | – | phosphorylation up-regulates activity | 9109492 | SIGNOR-279268 | |
| CLK1 | ABL1 | Thr735 | DTEWRSVtLPRDLQS | phosphorylation down-regulates | 18794806 | SIGNOR-181031 |
| PAK2 | ABL1 | Ser619 | PTPPKRSsSFREMDG | phosphorylation down-regulates | 18161990 | SIGNOR-160219 |
| PDGFRB | ABL1 | Tyr226 | KRNKPTVyGVSPNYD | phosphorylation up-regulates activity | 19275932 | SIGNOR-278319 |
| SRC | ABL1 | Tyr226 | KRNKPTVyGVSPNYD | phosphorylation up-regulates activity | 11847100 | SIGNOR-246307 |
| PTPN12 | ABL1 | – | dephosphorylation down-regulates activity | 11163214 | SIGNOR-246222 | |
| PTPN13 | ABL1 | Tyr226 | KRNKPTVyGVSPNYD | dephosphorylation down-regulates activity | 28924170 | SIGNOR-277012 |
| STK3 | ABL1 | Thr735 | DTEWRSVtLPRDLQS | phosphorylation down-regulates | 18794806 | SIGNOR-181056 |
| SRC | ABL1 | Tyr393 | RLMTGDTyTAHAGAK | phosphorylation up-regulates activity | 11847100 | SIGNOR-246311 |
| PTPN1 | ABL1 | – | dephosphorylation down-regulates | 9566916 | SIGNOR-56815 | |
| CLK4 | ABL1 | Thr735 | DTEWRSVtLPRDLQS | phosphorylation down-regulates | 18794806 | SIGNOR-181052 |
| ABL1 | ABL1 | Tyr393 | RLMTGDTyTAHAGAK | phosphorylation up-regulates activity | 8441409 | SIGNOR-39142 |
| ERBB2 | ABL1 | – | phosphorylation up-regulates activity | 19275932 | SIGNOR-279407 | |
| ATM | ABL1 | Ser446 | PYPGIDLsQVYELLE | phosphorylation up-regulates | 9168116 | SIGNOR-48818 |
| BRAF | ABL1 | – | phosphorylation up-regulates activity | 28368422 | SIGNOR-278914 | |
| STK3/4 | ABL1 | – | phosphorylation down-regulates | 18794806 | SIGNOR-270219 | |
| PAK2 | ABL1 | Ser618 | APTPPKRsSSFREMD | phosphorylation down-regulates | 18161990 | SIGNOR-160215 |
| PDGFRB | ABL1 | Tyr393 | RLMTGDTyTAHAGAK | phosphorylation up-regulates activity | 19275932 | SIGNOR-278318 |
| PTPRG | ABL1 | Tyr413 | TAPESLAyNKFSIKS | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254691 |
| MST1R | ABL1 | – | phosphorylation up-regulates activity | 35569509 | SIGNOR-272999 | |
| ABL1 | ABL1 | Tyr393 | FGLSRLMtGDTYTAH | phosphorylation up-regulates activity | 10964922 | SIGNOR-260781 |
| LATS2 | ABL1 | Thr178 | VYHYRINtASDGKLY | phosphorylation down-regulates activity | 23852372 | SIGNOR-276497 |
| ABL1 | ABL1 | Tyr393 | RLMTGDTyTAHAGAK | phosphorylation up-regulates activity | 11781820 | SIGNOR-113659 |
| TTK | ABL1 | Thr735 | DTEWRSVtLPRDLQS | phosphorylation down-regulates | 18794806 | SIGNOR-181064 |
| PTPN12 | ABL1 | Tyr393 | RLMTGDTyTAHAGAK | dephosphorylation down-regulates activity | 11163214 | SIGNOR-235568 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| STK4 | phosphorylation up-regulates → | ABL1 PThr735 | phosphorylation down-regulates ⊣ | ABL1 | 18794806 | SIGNOR-181060 |
| CLK1 | phosphorylation up-regulates → | ABL1 PThr735 | phosphorylation down-regulates ⊣ | ABL1 | 18794806 | SIGNOR-181031 |
| PAK2 | phosphorylation up-regulates → | ABL1 PSer619 | phosphorylation down-regulates ⊣ | ABL1 | 18161990 | SIGNOR-160219 |
| PDGFRB | phosphorylation up-regulates → | ABL1 PTyr226 | phosphorylation up-regulates → | ABL1 | 19275932 | SIGNOR-278319 |
| SRC | phosphorylation up-regulates → | ABL1 PTyr226 | phosphorylation up-regulates → | ABL1 | 11847100 | SIGNOR-246307 |
| PTPN13 | dephosphorylation down-regulates ⊣ | ABL1 PTyr226 | dephosphorylation up-regulates → | ABL1 | 28924170 | SIGNOR-277012 |
| STK3 | phosphorylation up-regulates → | ABL1 PThr735 | phosphorylation down-regulates ⊣ | ABL1 | 18794806 | SIGNOR-181056 |
| SRC | phosphorylation up-regulates → | ABL1 PTyr393 | phosphorylation up-regulates → | ABL1 | 11847100 | SIGNOR-246311 |
| CLK4 | phosphorylation up-regulates → | ABL1 PThr735 | phosphorylation down-regulates ⊣ | ABL1 | 18794806 | SIGNOR-181052 |
| ABL1 | phosphorylation up-regulates → | ABL1 PTyr393 | phosphorylation up-regulates → | ABL1 | 8441409 | SIGNOR-39142 |
| ATM | phosphorylation up-regulates → | ABL1 PSer446 | phosphorylation up-regulates → | ABL1 | 9168116 | SIGNOR-48818 |
| PAK2 | phosphorylation up-regulates → | ABL1 PSer618 | phosphorylation down-regulates ⊣ | ABL1 | 18161990 | SIGNOR-160215 |
| PDGFRB | phosphorylation up-regulates → | ABL1 PTyr393 | phosphorylation up-regulates → | ABL1 | 19275932 | SIGNOR-278318 |
| PTPRG | dephosphorylation down-regulates ⊣ | ABL1 PTyr413 | dephosphorylation up-regulates → | ABL1 | 25624455 | SIGNOR-254691 |
| ABL1 | phosphorylation up-regulates → | ABL1 PTyr393 | phosphorylation up-regulates → | ABL1 | 10964922 | SIGNOR-260781 |
| LATS2 | phosphorylation up-regulates → | ABL1 PThr178 | phosphorylation down-regulates ⊣ | ABL1 | 23852372 | SIGNOR-276497 |
| ABL1 | phosphorylation up-regulates → | ABL1 PTyr393 | phosphorylation up-regulates → | ABL1 | 11781820 | SIGNOR-113659 |
| TTK | phosphorylation up-regulates → | ABL1 PThr735 | phosphorylation down-regulates ⊣ | ABL1 | 18794806 | SIGNOR-181064 |
| PTPN12 | dephosphorylation down-regulates ⊣ | ABL1 PTyr393 | dephosphorylation up-regulates → | ABL1 | 11163214 | SIGNOR-235568 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| STK4 | phosphorylation down-regulates | ABL1 | SIGNOR-181060 |
| PRKDC | phosphorylation → up-regulates activity | ABL1 | SIGNOR-279268 |
| CLK1 | phosphorylation down-regulates | ABL1 | SIGNOR-181031 |
| PAK2 | phosphorylation down-regulates | ABL1 | SIGNOR-160219 |
| PDGFRB | phosphorylation → up-regulates activity | ABL1 | SIGNOR-278319 |
| SRC | phosphorylation → up-regulates activity | ABL1 | SIGNOR-246307 |
| PTPN12 | dephosphorylation → down-regulates activity | ABL1 | SIGNOR-246222 |
| PTPN13 | dephosphorylation → down-regulates activity | ABL1 | SIGNOR-277012 |
| STK3 | phosphorylation down-regulates | ABL1 | SIGNOR-181056 |
| SRC | phosphorylation → up-regulates activity | ABL1 | SIGNOR-246311 |
| PTPN1 | dephosphorylation down-regulates | ABL1 | SIGNOR-56815 |
| CLK4 | phosphorylation down-regulates | ABL1 | SIGNOR-181052 |
| ABL1 | phosphorylation → up-regulates activity | ABL1 | SIGNOR-39142 |
| ERBB2 | phosphorylation → up-regulates activity | ABL1 | SIGNOR-279407 |
| ATM | phosphorylation → up-regulates | ABL1 | SIGNOR-48818 |
| BRAF | phosphorylation → up-regulates activity | ABL1 | SIGNOR-278914 |
| STK3/4 | phosphorylation down-regulates | ABL1 | SIGNOR-270219 |
| PAK2 | phosphorylation down-regulates | ABL1 | SIGNOR-160215 |
| PDGFRB | phosphorylation → up-regulates activity | ABL1 | SIGNOR-278318 |
| PTPRG | dephosphorylation → down-regulates activity | ABL1 | SIGNOR-254691 |
| MST1R | phosphorylation → up-regulates activity | ABL1 | SIGNOR-272999 |
| ABL1 | phosphorylation → up-regulates activity | ABL1 | SIGNOR-260781 |
| LATS2 | phosphorylation → down-regulates activity | ABL1 | SIGNOR-276497 |
| ABL1 | phosphorylation → up-regulates activity | ABL1 | SIGNOR-113659 |
| TTK | phosphorylation down-regulates | ABL1 | SIGNOR-181064 |
| PTPN12 | dephosphorylation → down-regulates activity | ABL1 | SIGNOR-235568 |