| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TTK | ABL1 | Thr735 | DTEWRSVtLPRDLQS | phosphorylation down-regulates | 18794806 | SIGNOR-181064 |
| CLK1 | ABL1 | Thr735 | DTEWRSVtLPRDLQS | phosphorylation down-regulates | 18794806 | SIGNOR-181031 |
| STK3 | ABL1 | Thr735 | DTEWRSVtLPRDLQS | phosphorylation down-regulates | 18794806 | SIGNOR-181056 |
| CLK4 | ABL1 | Thr735 | DTEWRSVtLPRDLQS | phosphorylation down-regulates | 18794806 | SIGNOR-181052 |
| STK4 | ABL1 | Thr735 | DTEWRSVtLPRDLQS | phosphorylation down-regulates | 18794806 | SIGNOR-181060 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TTK | phosphorylation up-regulates → | ABL1 PThr735 | phosphorylation down-regulates ⊣ | ABL1 | 18794806 | SIGNOR-181064 |
| CLK1 | phosphorylation up-regulates → | ABL1 PThr735 | phosphorylation down-regulates ⊣ | ABL1 | 18794806 | SIGNOR-181031 |
| STK3 | phosphorylation up-regulates → | ABL1 PThr735 | phosphorylation down-regulates ⊣ | ABL1 | 18794806 | SIGNOR-181056 |
| CLK4 | phosphorylation up-regulates → | ABL1 PThr735 | phosphorylation down-regulates ⊣ | ABL1 | 18794806 | SIGNOR-181052 |
| STK4 | phosphorylation up-regulates → | ABL1 PThr735 | phosphorylation down-regulates ⊣ | ABL1 | 18794806 | SIGNOR-181060 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| TTK | phosphorylation down-regulates | ABL1 | SIGNOR-181064 |
| CLK1 | phosphorylation down-regulates | ABL1 | SIGNOR-181031 |
| STK3 | phosphorylation down-regulates | ABL1 | SIGNOR-181056 |
| CLK4 | phosphorylation down-regulates | ABL1 | SIGNOR-181052 |
| STK4 | phosphorylation down-regulates | ABL1 | SIGNOR-181060 |
