| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ABL1 | ABL1 | Tyr393 | RLMTGDTyTAHAGAK | phosphorylation up-regulates activity | 11781820 | SIGNOR-113659 |
| PDGFRB | ABL1 | Tyr393 | RLMTGDTyTAHAGAK | phosphorylation up-regulates activity | 19275932 | SIGNOR-278318 |
| SRC | ABL1 | Tyr393 | RLMTGDTyTAHAGAK | phosphorylation up-regulates activity | 11847100 | SIGNOR-246311 |
| ABL1 | ABL1 | Tyr393 | FGLSRLMtGDTYTAH | phosphorylation up-regulates activity | 10964922 | SIGNOR-260781 |
| PTPN12 | ABL1 | Tyr393 | RLMTGDTyTAHAGAK | dephosphorylation down-regulates activity | 11163214 | SIGNOR-235568 |
| ABL1 | ABL1 | Tyr393 | RLMTGDTyTAHAGAK | phosphorylation up-regulates activity | 8441409 | SIGNOR-39142 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ABL1 | phosphorylation up-regulates → | ABL1 PTyr393 | phosphorylation up-regulates → | ABL1 | 11781820 | SIGNOR-113659 |
| PDGFRB | phosphorylation up-regulates → | ABL1 PTyr393 | phosphorylation up-regulates → | ABL1 | 19275932 | SIGNOR-278318 |
| SRC | phosphorylation up-regulates → | ABL1 PTyr393 | phosphorylation up-regulates → | ABL1 | 11847100 | SIGNOR-246311 |
| ABL1 | phosphorylation up-regulates → | ABL1 PTyr393 | phosphorylation up-regulates → | ABL1 | 10964922 | SIGNOR-260781 |
| PTPN12 | dephosphorylation down-regulates ⊣ | ABL1 PTyr393 | dephosphorylation up-regulates → | ABL1 | 11163214 | SIGNOR-235568 |
| ABL1 | phosphorylation up-regulates → | ABL1 PTyr393 | phosphorylation up-regulates → | ABL1 | 8441409 | SIGNOR-39142 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ABL1 | phosphorylation → up-regulates activity | ABL1 | SIGNOR-113659 |
| PDGFRB | phosphorylation → up-regulates activity | ABL1 | SIGNOR-278318 |
| SRC | phosphorylation → up-regulates activity | ABL1 | SIGNOR-246311 |
| ABL1 | phosphorylation → up-regulates activity | ABL1 | SIGNOR-260781 |
| PTPN12 | dephosphorylation → down-regulates activity | ABL1 | SIGNOR-235568 |
| ABL1 | phosphorylation → up-regulates activity | ABL1 | SIGNOR-39142 |
