| Name | EGFR |
| ID | P00533 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 712-979 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ERK1/2 | EGFR | Thr693 | RELVEPLtPSGEAPN | phosphorylation down-regulates | 10816576 | SIGNOR-244529 |
| Gbeta | EGFR | – | phosphorylation down-regulates | 1651322 | SIGNOR-270017 | |
| PKN1 | EGFR | Thr678 | RHIVRKRtLRRLLQE | phosphorylation down-regulates activity | 21749319 | SIGNOR-174755 |
| LYN | EGFR | Tyr1125 | APSRDPHyQDPHSTA | phosphorylation up-regulates activity | 22430206 | SIGNOR-279205 |
| CAMK2G | EGFR | Ser1071 | SFLQRYSsDPTGALT | phosphorylation down-regulates activity | 1309762 | SIGNOR-250695 |
| MAPK11 | EGFR | – | phosphorylation down-regulates | 16932740 | SIGNOR-149086 | |
| PTPN9 | EGFR | – | dephosphorylation down-regulates activity | 20335174 | SIGNOR-277130 | |
| AXL | EGFR | Tyr1197 | STAENAEyLRVAPQS | phosphorylation up-regulates activity | 25873175 | SIGNOR-279141 |
| FRK | EGFR | – | phosphorylation down-regulates activity | 23318459 | SIGNOR-279177 | |
| EGFR | EGFR | Tyr1197 | STAENAEyLRVAPQS | phosphorylation up-regulates activity | 16122376 | SIGNOR-235951 |
| ABL1 | EGFR | Tyr1197 | STAENAEyLRVAPQS | phosphorylation up-regulates | 16943190 | SIGNOR-149277 |
| PTPRJ | EGFR | Tyr1092 | TFLPVPEyINQSVPK | dephosphorylation up-regulates quantity by stabilization | 19836242 | SIGNOR-248698 |
| CDK1 | EGFR | Ser1026 | PQQGFFSsPSTSRTP | phosphorylation down-regulates | 8360196 | SIGNOR-38313 |
| PTPRK | EGFR | Tyr1197 | STAENAEyLRVAPQS | dephosphorylation unknown | 16263724 | SIGNOR-248723 |
| SRC | EGFR | Tyr869 | LGAEEKEyHAEGGKV | phosphorylation up-regulates activity | 11983694 | SIGNOR-235921 |
| MAPK3 | EGFR | Thr693 | RELVEPLtPSGEAPN | phosphorylation down-regulates | 1651322 | SIGNOR-20549 |
| PTPRG | EGFR | Tyr1172 | ISLDNPDyQQDFFPK | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254700 |
| PTPRG | EGFR | Tyr1069 | EDSFLQRySSDPTGA | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254699 |
| CAMK2A | EGFR | Ser1166 | QKGSHQIsLDNPDYQ | phosphorylation down-regulates activity | 10347170 | SIGNOR-250624 |
| CAMK2A | EGFR | Ser768 | DEAYVMAsVDNPHVC | phosphorylation down-regulates activity | 10347170 | SIGNOR-250625 |
| CAMK2A | EGFR | Ser1081 | TGALTEDsIDDTFLP | phosphorylation down-regulates activity | 10347170 | SIGNOR-250622 |
| CAMK2A | EGFR | Ser1071 | SFLQRYSsDPTGALT | phosphorylation down-regulates activity | 10347170 | SIGNOR-250621 |
| CAMK2A | EGFR | Ser1070 | DSFLQRYsSDPTGAL | phosphorylation down-regulates activity | 10347170 | SIGNOR-250620 |
| EGFR | EGFR | Tyr1016 | DVVDADEyLIPQQGF | phosphorylation up-regulates activity | 16122376 | SIGNOR-236527 |
| EGFR | EGFR | Tyr1092 | TFLPVPEyINQSVPK | phosphorylation up-regulates activity | 16122376 | SIGNOR-236523 |
| CAMK2A | EGFR | Ser1120 | QPLNPAPsRDPHYQD | phosphorylation down-regulates activity | 10347170 | SIGNOR-250623 |
| PTPN1 | EGFR | – | dephosphorylation down-regulates activity | 18253097 | SIGNOR-276981 | |
| MAPK14 | EGFR | – | phosphorylation down-regulates | 16932740 | SIGNOR-149089 | |
| EGFR | EGFR | Tyr1172 | ISLDNPDyQQDFFPK | phosphorylation up-regulates activity | 10653583 | SIGNOR-236467 |
| PTPN2 | EGFR | – | dephosphorylation down-regulates | 11514572 | SIGNOR-109804 | |
| PTPN1 | EGFR | Tyr1016 | DVVDADEyLIPQQGF | dephosphorylation down-regulates activity | 8621392 | SIGNOR-248407 |
| SRC | EGFR | Tyr1016 | DVVDADEyLIPQQGF | phosphorylation up-regulates activity | 8845374 | SIGNOR-44239 |
| PTPRS | EGFR | – | dephosphorylation down-regulates activity | 12018405 | SIGNOR-277145 | |
| PTPRJ | EGFR | Tyr1197 | STAENAEyLRVAPQS | dephosphorylation up-regulates quantity by stabilization | 19836242 | SIGNOR-248699 |
| SRC | EGFR | Tyr1172 | ISLDNPDyQQDFFPK | phosphorylation up-regulates activity | 8845374 | SIGNOR-44251 |
| ERBB2 | EGFR | Tyr1197 | STAENAEyLRVAPQS | phosphorylation up-regulates activity | 23027125 | SIGNOR-278474 |
| PTPRF | EGFR | – | dephosphorylation down-regulates activity | 12018405 | SIGNOR-277029 | |
| DUSP3 | EGFR | Tyr1016 | DVVDADEyLIPQQGF | dephosphorylation down-regulates activity | 21262974 | SIGNOR-248532 |
| EGFR | EGFR | Tyr869 | LGAEEKEyHAEGGKV | phosphorylation up-regulates activity | 16122376 | SIGNOR-235956 |
| EGFR | EGFR | Tyr1016 | DVVDADEyLIPQQGF | phosphorylation up-regulates activity | 10653583 | SIGNOR-236475 |
| PRKCA | EGFR | Thr678 | RHIVRKRtLRRLLQE | phosphorylation down-regulates activity | 10816576 | SIGNOR-77421 |
| PTPN11 | EGFR | Tyr1016 | DVVDADEyLIPQQGF | dephosphorylation down-regulates activity | 14560030 | SIGNOR-248666 |
| PTPN6 | EGFR | Tyr1197 | STAENAEyLRVAPQS | dephosphorylation down-regulates | 9733788 | SIGNOR-59965 |
| AURKA | EGFR | Thr678 | RHIVRKRtLRRLLQE | phosphorylation up-regulates activity | 23520446 | SIGNOR-279590 |
| EGFR | EGFR | Tyr1110 | GSVQNPVyHNQPLNP | phosphorylation up-regulates activity | 16122376 | SIGNOR-236516 |
| SRC | EGFR | Tyr1125 | APSRDPHyQDPHSTA | phosphorylation up-regulates | 8845374 | SIGNOR-44247 |
| ABL1 | EGFR | Tyr1172 | ISLDNPDyQQDFFPK | phosphorylation up-regulates | 16943190 | SIGNOR-149273 |
| AURKA | EGFR | Ser1070 | DSFLQRYsSDPTGAL | phosphorylation up-regulates activity | 23520446 | SIGNOR-279589 |
| EGFR | EGFR | Tyr1069 | EDSFLQRySSDPTGA | phosphorylation up-regulates activity | 10635327 | SIGNOR-251093 |
| EGFR | EGFR | Tyr1092 | TFLPVPEyINQSVPK | phosphorylation up-regulates activity | 10653583 | SIGNOR-236479 |
| PTPN11 | EGFR | Tyr1016 | DVVDADEyLIPQQGF | dephosphorylation down-regulates activity | 12582165 | SIGNOR-236424 |
| CAMK2A | EGFR | Ser1064 | SCPIKEDsFLQRYSS | phosphorylation down-regulates activity | 10347170 | SIGNOR-250619 |
| MAPK1 | EGFR | Thr693 | RELVEPLtPSGEAPN | phosphorylation down-regulates activity | 1651322 | SIGNOR-20545 |
| SRC | EGFR | Tyr1110 | GSVQNPVyHNQPLNP | phosphorylation up-regulates activity | 8845374 | SIGNOR-44243 |
| PTPN2 | EGFR | – | dephosphorylation down-regulates | 15592458 | SIGNOR-132316 | |
| PTPRH | EGFR | – | dephosphorylation down-regulates activity | 28065597 | SIGNOR-277090 | |
| EGFR | EGFR | Tyr1110 | GSVQNPVyHNQPLNP | phosphorylation up-regulates activity | 10653583 | SIGNOR-236483 |
| PTPRK | EGFR | Tyr1092 | TFLPVPEyINQSVPK | dephosphorylation unknown | 16263724 | SIGNOR-248722 |
| EGFR | EGFR | Tyr1197 | STAENAEyLRVAPQS | phosphorylation up-regulates activity | 10653583 | SIGNOR-236471 |
| PRKG2 | EGFR | Thr430 | LEIIRGRtKQHGQFS | phosphorylation down-regulates activity | 35226996 | SIGNOR-277589 |
| EGFR | EGFR | Tyr1172 | ISLDNPDyQQDFFPK | phosphorylation up-regulates activity | 16122376 | SIGNOR-236531 |
| JAK2 | EGFR | Tyr1069 | EDSFLQRySSDPTGA | phosphorylation up-regulates activity | 9363897 | SIGNOR-251347 |
| EGFR | EGFR | Tyr869 | LGAEEKEyHAEGGKV | phosphorylation up-regulates activity | 10653583 | SIGNOR-236487 |
| PRKCD | EGFR | Thr678 | RHIVRKRtLRRLLQE | phosphorylation down-regulates activity | 1860884 | SIGNOR-248858 |
| PTPRJ | EGFR | Tyr1069 | EDSFLQRySSDPTGA | dephosphorylation up-regulates quantity by stabilization | 19836242 | SIGNOR-248697 |
| CAMK2G | EGFR | Ser1070 | DSFLQRYsSDPTGAL | phosphorylation down-regulates activity | 1309762 | SIGNOR-250694 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ERK1/2 | phosphorylation up-regulates → | EGFR PThr693 | phosphorylation down-regulates ⊣ | EGFR | 10816576 | SIGNOR-244529 |
| PKN1 | phosphorylation up-regulates → | EGFR PThr678 | phosphorylation down-regulates ⊣ | EGFR | 21749319 | SIGNOR-174755 |
| LYN | phosphorylation up-regulates → | EGFR PTyr1125 | phosphorylation up-regulates → | EGFR | 22430206 | SIGNOR-279205 |
| CAMK2G | phosphorylation up-regulates → | EGFR PSer1071 | phosphorylation down-regulates ⊣ | EGFR | 1309762 | SIGNOR-250695 |
| AXL | phosphorylation up-regulates → | EGFR PTyr1197 | phosphorylation up-regulates → | EGFR | 25873175 | SIGNOR-279141 |
| EGFR | phosphorylation up-regulates → | EGFR PTyr1197 | phosphorylation up-regulates → | EGFR | 16122376 | SIGNOR-235951 |
| ABL1 | phosphorylation up-regulates → | EGFR PTyr1197 | phosphorylation up-regulates → | EGFR | 16943190 | SIGNOR-149277 |
| PTPRJ | dephosphorylation down-regulates ⊣ | EGFR PTyr1092 | dephosphorylation down-regulates ⊣ | EGFR | 19836242 | SIGNOR-248698 |
| CDK1 | phosphorylation up-regulates → | EGFR PSer1026 | phosphorylation down-regulates ⊣ | EGFR | 8360196 | SIGNOR-38313 |
| PTPRK | dephosphorylation down-regulates ⊣ | EGFR PTyr1197 | dephosphorylation up-regulates → | EGFR | 16263724 | SIGNOR-248723 |
| SRC | phosphorylation up-regulates → | EGFR PTyr869 | phosphorylation up-regulates → | EGFR | 11983694 | SIGNOR-235921 |
| MAPK3 | phosphorylation up-regulates → | EGFR PThr693 | phosphorylation down-regulates ⊣ | EGFR | 1651322 | SIGNOR-20549 |
| PTPRG | dephosphorylation down-regulates ⊣ | EGFR PTyr1172 | dephosphorylation down-regulates ⊣ | EGFR | 25624455 | SIGNOR-254700 |
| PTPRG | dephosphorylation down-regulates ⊣ | EGFR PTyr1069 | dephosphorylation up-regulates → | EGFR | 25624455 | SIGNOR-254699 |
| CAMK2A | phosphorylation up-regulates → | EGFR PSer1166 | phosphorylation down-regulates ⊣ | EGFR | 10347170 | SIGNOR-250624 |
| CAMK2A | phosphorylation up-regulates → | EGFR PSer768 | phosphorylation down-regulates ⊣ | EGFR | 10347170 | SIGNOR-250625 |
| CAMK2A | phosphorylation up-regulates → | EGFR PSer1081 | phosphorylation down-regulates ⊣ | EGFR | 10347170 | SIGNOR-250622 |
| CAMK2A | phosphorylation up-regulates → | EGFR PSer1071 | phosphorylation down-regulates ⊣ | EGFR | 10347170 | SIGNOR-250621 |
| CAMK2A | phosphorylation up-regulates → | EGFR PSer1070 | phosphorylation down-regulates ⊣ | EGFR | 10347170 | SIGNOR-250620 |
| EGFR | phosphorylation up-regulates → | EGFR PTyr1016 | phosphorylation up-regulates → | EGFR | 16122376 | SIGNOR-236527 |
| EGFR | phosphorylation up-regulates → | EGFR PTyr1092 | phosphorylation up-regulates → | EGFR | 16122376 | SIGNOR-236523 |
| CAMK2A | phosphorylation up-regulates → | EGFR PSer1120 | phosphorylation down-regulates ⊣ | EGFR | 10347170 | SIGNOR-250623 |
| EGFR | phosphorylation up-regulates → | EGFR PTyr1172 | phosphorylation up-regulates → | EGFR | 10653583 | SIGNOR-236467 |
| PTPN1 | dephosphorylation down-regulates ⊣ | EGFR PTyr1016 | dephosphorylation up-regulates → | EGFR | 8621392 | SIGNOR-248407 |
| SRC | phosphorylation up-regulates → | EGFR PTyr1016 | phosphorylation up-regulates → | EGFR | 8845374 | SIGNOR-44239 |
| PTPRJ | dephosphorylation down-regulates ⊣ | EGFR PTyr1197 | dephosphorylation down-regulates ⊣ | EGFR | 19836242 | SIGNOR-248699 |
| SRC | phosphorylation up-regulates → | EGFR PTyr1172 | phosphorylation up-regulates → | EGFR | 8845374 | SIGNOR-44251 |
| ERBB2 | phosphorylation up-regulates → | EGFR PTyr1197 | phosphorylation up-regulates → | EGFR | 23027125 | SIGNOR-278474 |
| DUSP3 | dephosphorylation down-regulates ⊣ | EGFR PTyr1016 | dephosphorylation up-regulates → | EGFR | 21262974 | SIGNOR-248532 |
| EGFR | phosphorylation up-regulates → | EGFR PTyr869 | phosphorylation up-regulates → | EGFR | 16122376 | SIGNOR-235956 |
| EGFR | phosphorylation up-regulates → | EGFR PTyr1016 | phosphorylation up-regulates → | EGFR | 10653583 | SIGNOR-236475 |
| PRKCA | phosphorylation up-regulates → | EGFR PThr678 | phosphorylation down-regulates ⊣ | EGFR | 10816576 | SIGNOR-77421 |
| PTPN11 | dephosphorylation down-regulates ⊣ | EGFR PTyr1016 | dephosphorylation up-regulates → | EGFR | 14560030 | SIGNOR-248666 |
| PTPN6 | dephosphorylation down-regulates ⊣ | EGFR PTyr1197 | dephosphorylation up-regulates → | EGFR | 9733788 | SIGNOR-59965 |
| AURKA | phosphorylation up-regulates → | EGFR PThr678 | phosphorylation up-regulates → | EGFR | 23520446 | SIGNOR-279590 |
| EGFR | phosphorylation up-regulates → | EGFR PTyr1110 | phosphorylation up-regulates → | EGFR | 16122376 | SIGNOR-236516 |
| SRC | phosphorylation up-regulates → | EGFR PTyr1125 | phosphorylation up-regulates → | EGFR | 8845374 | SIGNOR-44247 |
| ABL1 | phosphorylation up-regulates → | EGFR PTyr1172 | phosphorylation up-regulates → | EGFR | 16943190 | SIGNOR-149273 |
| AURKA | phosphorylation up-regulates → | EGFR PSer1070 | phosphorylation up-regulates → | EGFR | 23520446 | SIGNOR-279589 |
| EGFR | phosphorylation up-regulates → | EGFR PTyr1069 | phosphorylation up-regulates → | EGFR | 10635327 | SIGNOR-251093 |
| EGFR | phosphorylation up-regulates → | EGFR PTyr1092 | phosphorylation up-regulates → | EGFR | 10653583 | SIGNOR-236479 |
| PTPN11 | dephosphorylation down-regulates ⊣ | EGFR PTyr1016 | dephosphorylation up-regulates → | EGFR | 12582165 | SIGNOR-236424 |
| CAMK2A | phosphorylation up-regulates → | EGFR PSer1064 | phosphorylation down-regulates ⊣ | EGFR | 10347170 | SIGNOR-250619 |
| MAPK1 | phosphorylation up-regulates → | EGFR PThr693 | phosphorylation down-regulates ⊣ | EGFR | 1651322 | SIGNOR-20545 |
| SRC | phosphorylation up-regulates → | EGFR PTyr1110 | phosphorylation up-regulates → | EGFR | 8845374 | SIGNOR-44243 |
| EGFR | phosphorylation up-regulates → | EGFR PTyr1110 | phosphorylation up-regulates → | EGFR | 10653583 | SIGNOR-236483 |
| PTPRK | dephosphorylation down-regulates ⊣ | EGFR PTyr1092 | dephosphorylation up-regulates → | EGFR | 16263724 | SIGNOR-248722 |
| EGFR | phosphorylation up-regulates → | EGFR PTyr1197 | phosphorylation up-regulates → | EGFR | 10653583 | SIGNOR-236471 |
| PRKG2 | phosphorylation up-regulates → | EGFR PThr430 | phosphorylation down-regulates ⊣ | EGFR | 35226996 | SIGNOR-277589 |
| EGFR | phosphorylation up-regulates → | EGFR PTyr1172 | phosphorylation up-regulates → | EGFR | 16122376 | SIGNOR-236531 |
| JAK2 | phosphorylation up-regulates → | EGFR PTyr1069 | phosphorylation up-regulates → | EGFR | 9363897 | SIGNOR-251347 |
| EGFR | phosphorylation up-regulates → | EGFR PTyr869 | phosphorylation up-regulates → | EGFR | 10653583 | SIGNOR-236487 |
| PRKCD | phosphorylation up-regulates → | EGFR PThr678 | phosphorylation down-regulates ⊣ | EGFR | 1860884 | SIGNOR-248858 |
| PTPRJ | dephosphorylation down-regulates ⊣ | EGFR PTyr1069 | dephosphorylation down-regulates ⊣ | EGFR | 19836242 | SIGNOR-248697 |
| CAMK2G | phosphorylation up-regulates → | EGFR PSer1070 | phosphorylation down-regulates ⊣ | EGFR | 1309762 | SIGNOR-250694 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ERK1/2 | phosphorylation down-regulates | EGFR | SIGNOR-244529 |
| Gbeta | phosphorylation down-regulates | EGFR | SIGNOR-270017 |
| PKN1 | phosphorylation → down-regulates activity | EGFR | SIGNOR-174755 |
| LYN | phosphorylation → up-regulates activity | EGFR | SIGNOR-279205 |
| CAMK2G | phosphorylation → down-regulates activity | EGFR | SIGNOR-250695 |
| MAPK11 | phosphorylation down-regulates | EGFR | SIGNOR-149086 |
| PTPN9 | dephosphorylation → down-regulates activity | EGFR | SIGNOR-277130 |
| AXL | phosphorylation → up-regulates activity | EGFR | SIGNOR-279141 |
| FRK | phosphorylation → down-regulates activity | EGFR | SIGNOR-279177 |
| EGFR | phosphorylation → up-regulates activity | EGFR | SIGNOR-235951 |
| ABL1 | phosphorylation → up-regulates | EGFR | SIGNOR-149277 |
| PTPRJ | dephosphorylation → up-regulates quantity by stabilization | EGFR | SIGNOR-248698 |
| CDK1 | phosphorylation down-regulates | EGFR | SIGNOR-38313 |
| PTPRK | dephosphorylation → unknown | EGFR | SIGNOR-248723 |
| SRC | phosphorylation → up-regulates activity | EGFR | SIGNOR-235921 |
| MAPK3 | phosphorylation down-regulates | EGFR | SIGNOR-20549 |
| PTPRG | dephosphorylation → up-regulates activity | EGFR | SIGNOR-254700 |
| PTPRG | dephosphorylation → down-regulates activity | EGFR | SIGNOR-254699 |
| CAMK2A | phosphorylation → down-regulates activity | EGFR | SIGNOR-250624 |
| CAMK2A | phosphorylation → down-regulates activity | EGFR | SIGNOR-250625 |
| CAMK2A | phosphorylation → down-regulates activity | EGFR | SIGNOR-250622 |
| CAMK2A | phosphorylation → down-regulates activity | EGFR | SIGNOR-250621 |
| CAMK2A | phosphorylation → down-regulates activity | EGFR | SIGNOR-250620 |
| EGFR | phosphorylation → up-regulates activity | EGFR | SIGNOR-236527 |
| EGFR | phosphorylation → up-regulates activity | EGFR | SIGNOR-236523 |
| CAMK2A | phosphorylation → down-regulates activity | EGFR | SIGNOR-250623 |
| PTPN1 | dephosphorylation → down-regulates activity | EGFR | SIGNOR-276981 |
| MAPK14 | phosphorylation down-regulates | EGFR | SIGNOR-149089 |
| EGFR | phosphorylation → up-regulates activity | EGFR | SIGNOR-236467 |
| PTPN2 | dephosphorylation down-regulates | EGFR | SIGNOR-109804 |
| PTPN1 | dephosphorylation → down-regulates activity | EGFR | SIGNOR-248407 |
| SRC | phosphorylation → up-regulates activity | EGFR | SIGNOR-44239 |
| PTPRS | dephosphorylation → down-regulates activity | EGFR | SIGNOR-277145 |
| PTPRJ | dephosphorylation → up-regulates quantity by stabilization | EGFR | SIGNOR-248699 |
| SRC | phosphorylation → up-regulates activity | EGFR | SIGNOR-44251 |
| ERBB2 | phosphorylation → up-regulates activity | EGFR | SIGNOR-278474 |
| PTPRF | dephosphorylation → down-regulates activity | EGFR | SIGNOR-277029 |
| DUSP3 | dephosphorylation → down-regulates activity | EGFR | SIGNOR-248532 |
| EGFR | phosphorylation → up-regulates activity | EGFR | SIGNOR-235956 |
| EGFR | phosphorylation → up-regulates activity | EGFR | SIGNOR-236475 |
| PRKCA | phosphorylation → down-regulates activity | EGFR | SIGNOR-77421 |
| PTPN11 | dephosphorylation → down-regulates activity | EGFR | SIGNOR-248666 |
| PTPN6 | dephosphorylation down-regulates | EGFR | SIGNOR-59965 |
| AURKA | phosphorylation → up-regulates activity | EGFR | SIGNOR-279590 |
| EGFR | phosphorylation → up-regulates activity | EGFR | SIGNOR-236516 |
| SRC | phosphorylation → up-regulates | EGFR | SIGNOR-44247 |
| ABL1 | phosphorylation → up-regulates | EGFR | SIGNOR-149273 |
| AURKA | phosphorylation → up-regulates activity | EGFR | SIGNOR-279589 |
| EGFR | phosphorylation → up-regulates activity | EGFR | SIGNOR-251093 |
| EGFR | phosphorylation → up-regulates activity | EGFR | SIGNOR-236479 |
| PTPN11 | dephosphorylation → down-regulates activity | EGFR | SIGNOR-236424 |
| CAMK2A | phosphorylation → down-regulates activity | EGFR | SIGNOR-250619 |
| MAPK1 | phosphorylation → down-regulates activity | EGFR | SIGNOR-20545 |
| SRC | phosphorylation → up-regulates activity | EGFR | SIGNOR-44243 |
| PTPN2 | dephosphorylation down-regulates | EGFR | SIGNOR-132316 |
| PTPRH | dephosphorylation → down-regulates activity | EGFR | SIGNOR-277090 |
| EGFR | phosphorylation → up-regulates activity | EGFR | SIGNOR-236483 |
| PTPRK | dephosphorylation → unknown | EGFR | SIGNOR-248722 |
| EGFR | phosphorylation → up-regulates activity | EGFR | SIGNOR-236471 |
| PRKG2 | phosphorylation → down-regulates activity | EGFR | SIGNOR-277589 |
| EGFR | phosphorylation → up-regulates activity | EGFR | SIGNOR-236531 |
| JAK2 | phosphorylation → up-regulates activity | EGFR | SIGNOR-251347 |
| EGFR | phosphorylation → up-regulates activity | EGFR | SIGNOR-236487 |
| PRKCD | phosphorylation → down-regulates activity | EGFR | SIGNOR-248858 |
| PTPRJ | dephosphorylation → up-regulates quantity by stabilization | EGFR | SIGNOR-248697 |
| CAMK2G | phosphorylation → down-regulates activity | EGFR | SIGNOR-250694 |