| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | EGFR | Thr678 | RHIVRKRtLRRLLQE | phosphorylation down-regulates activity | 10816576 | SIGNOR-77421 |
| AURKA | EGFR | Thr678 | RHIVRKRtLRRLLQE | phosphorylation up-regulates activity | 23520446 | SIGNOR-279590 |
| PKN1 | EGFR | Thr678 | RHIVRKRtLRRLLQE | phosphorylation down-regulates activity | 21749319 | SIGNOR-174755 |
| PRKCD | EGFR | Thr678 | RHIVRKRtLRRLLQE | phosphorylation down-regulates activity | 1860884 | SIGNOR-248858 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | phosphorylation up-regulates → | EGFR PThr678 | phosphorylation down-regulates ⊣ | EGFR | 10816576 | SIGNOR-77421 |
| AURKA | phosphorylation up-regulates → | EGFR PThr678 | phosphorylation up-regulates → | EGFR | 23520446 | SIGNOR-279590 |
| PKN1 | phosphorylation up-regulates → | EGFR PThr678 | phosphorylation down-regulates ⊣ | EGFR | 21749319 | SIGNOR-174755 |
| PRKCD | phosphorylation up-regulates → | EGFR PThr678 | phosphorylation down-regulates ⊣ | EGFR | 1860884 | SIGNOR-248858 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCA | phosphorylation → down-regulates activity | EGFR | SIGNOR-77421 |
| AURKA | phosphorylation → up-regulates activity | EGFR | SIGNOR-279590 |
| PKN1 | phosphorylation → down-regulates activity | EGFR | SIGNOR-174755 |
| PRKCD | phosphorylation → down-regulates activity | EGFR | SIGNOR-248858 |
