| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CAMK2A | EGFR | Ser1070 | DSFLQRYsSDPTGAL | phosphorylation down-regulates activity | 10347170 | SIGNOR-250620 |
| AURKA | EGFR | Ser1070 | DSFLQRYsSDPTGAL | phosphorylation up-regulates activity | 23520446 | SIGNOR-279589 |
| CAMK2G | EGFR | Ser1070 | DSFLQRYsSDPTGAL | phosphorylation down-regulates activity | 1309762 | SIGNOR-250694 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CAMK2A | phosphorylation up-regulates → | EGFR PSer1070 | phosphorylation down-regulates ⊣ | EGFR | 10347170 | SIGNOR-250620 |
| AURKA | phosphorylation up-regulates → | EGFR PSer1070 | phosphorylation up-regulates → | EGFR | 23520446 | SIGNOR-279589 |
| CAMK2G | phosphorylation up-regulates → | EGFR PSer1070 | phosphorylation down-regulates ⊣ | EGFR | 1309762 | SIGNOR-250694 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CAMK2A | phosphorylation → down-regulates activity | EGFR | SIGNOR-250620 |
| AURKA | phosphorylation → up-regulates activity | EGFR | SIGNOR-279589 |
| CAMK2G | phosphorylation → down-regulates activity | EGFR | SIGNOR-250694 |