| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRJ | EGFR | Tyr1092 | TFLPVPEyINQSVPK | dephosphorylation up-regulates quantity by stabilization | 19836242 | SIGNOR-248698 |
| EGFR | EGFR | Tyr1092 | TFLPVPEyINQSVPK | phosphorylation up-regulates activity | 10653583 | SIGNOR-236479 |
| PTPRK | EGFR | Tyr1092 | TFLPVPEyINQSVPK | dephosphorylation unknown | 16263724 | SIGNOR-248722 |
| EGFR | EGFR | Tyr1092 | TFLPVPEyINQSVPK | phosphorylation up-regulates activity | 16122376 | SIGNOR-236523 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRJ | dephosphorylation down-regulates ⊣ | EGFR PTyr1092 | dephosphorylation down-regulates ⊣ | EGFR | 19836242 | SIGNOR-248698 |
| EGFR | phosphorylation up-regulates → | EGFR PTyr1092 | phosphorylation up-regulates → | EGFR | 10653583 | SIGNOR-236479 |
| PTPRK | dephosphorylation down-regulates ⊣ | EGFR PTyr1092 | dephosphorylation up-regulates → | EGFR | 16263724 | SIGNOR-248722 |
| EGFR | phosphorylation up-regulates → | EGFR PTyr1092 | phosphorylation up-regulates → | EGFR | 16122376 | SIGNOR-236523 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPRJ | dephosphorylation → up-regulates quantity by stabilization | EGFR | SIGNOR-248698 |
| EGFR | phosphorylation → up-regulates activity | EGFR | SIGNOR-236479 |
| PTPRK | dephosphorylation → unknown | EGFR | SIGNOR-248722 |
| EGFR | phosphorylation → up-regulates activity | EGFR | SIGNOR-236523 |