| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EGFR | EGFR | Tyr1110 | GSVQNPVyHNQPLNP | phosphorylation up-regulates activity | 16122376 | SIGNOR-236516 |
| SRC | EGFR | Tyr1110 | GSVQNPVyHNQPLNP | phosphorylation up-regulates activity | 8845374 | SIGNOR-44243 |
| EGFR | EGFR | Tyr1110 | GSVQNPVyHNQPLNP | phosphorylation up-regulates activity | 10653583 | SIGNOR-236483 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EGFR | phosphorylation up-regulates → | EGFR PTyr1110 | phosphorylation up-regulates → | EGFR | 16122376 | SIGNOR-236516 |
| SRC | phosphorylation up-regulates → | EGFR PTyr1110 | phosphorylation up-regulates → | EGFR | 8845374 | SIGNOR-44243 |
| EGFR | phosphorylation up-regulates → | EGFR PTyr1110 | phosphorylation up-regulates → | EGFR | 10653583 | SIGNOR-236483 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| EGFR | phosphorylation → up-regulates activity | EGFR | SIGNOR-236516 |
| SRC | phosphorylation → up-regulates activity | EGFR | SIGNOR-44243 |
| EGFR | phosphorylation → up-regulates activity | EGFR | SIGNOR-236483 |
