| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ERK1/2 | EGFR | Thr693 | RELVEPLtPSGEAPN | phosphorylation down-regulates | 10816576 | SIGNOR-244529 |
| MAPK3 | EGFR | Thr693 | RELVEPLtPSGEAPN | phosphorylation down-regulates | 1651322 | SIGNOR-20549 |
| MAPK1 | EGFR | Thr693 | RELVEPLtPSGEAPN | phosphorylation down-regulates activity | 1651322 | SIGNOR-20545 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ERK1/2 | phosphorylation up-regulates → | EGFR PThr693 | phosphorylation down-regulates ⊣ | EGFR | 10816576 | SIGNOR-244529 |
| MAPK3 | phosphorylation up-regulates → | EGFR PThr693 | phosphorylation down-regulates ⊣ | EGFR | 1651322 | SIGNOR-20549 |
| MAPK1 | phosphorylation up-regulates → | EGFR PThr693 | phosphorylation down-regulates ⊣ | EGFR | 1651322 | SIGNOR-20545 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ERK1/2 | phosphorylation down-regulates | EGFR | SIGNOR-244529 |
| MAPK3 | phosphorylation down-regulates | EGFR | SIGNOR-20549 |
| MAPK1 | phosphorylation → down-regulates activity | EGFR | SIGNOR-20545 |
