Entity Details

Name JAK2_Tyr1069
ID P00533
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PTPRGEGFRTyr1069EDSFLQRySSDPTGAdephosphorylation
down-regulates activity		25624455SIGNOR-254699
EGFREGFRTyr1069EDSFLQRySSDPTGAphosphorylation
up-regulates activity		10635327SIGNOR-251093
PTPRJEGFRTyr1069EDSFLQRySSDPTGAdephosphorylation
up-regulates quantity by stabilization		19836242SIGNOR-248697
JAK2EGFRTyr1069EDSFLQRySSDPTGAphosphorylation
up-regulates activity		9363897SIGNOR-251347
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PTPRGdephosphorylation
down-regulates
⊣
EGFR
PTyr1069		dephosphorylation
up-regulates
→		EGFR25624455SIGNOR-254699
EGFRphosphorylation
up-regulates
→
EGFR
PTyr1069		phosphorylation
up-regulates
→		EGFR10635327SIGNOR-251093
PTPRJdephosphorylation
down-regulates
⊣
EGFR
PTyr1069		dephosphorylation
down-regulates
⊣		EGFR19836242SIGNOR-248697
JAK2phosphorylation
up-regulates
→
EGFR
PTyr1069		phosphorylation
up-regulates
→		EGFR9363897SIGNOR-251347
Regulator Mechanism/Effect Target SIGNOR-ID
PTPRGdephosphorylation
→
down-regulates activity 		EGFRSIGNOR-254699
EGFRphosphorylation
→
up-regulates activity 		EGFRSIGNOR-251093
PTPRJdephosphorylation
→
up-regulates quantity by stabilization 		EGFRSIGNOR-248697
JAK2phosphorylation
→
up-regulates activity 		EGFRSIGNOR-251347