| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRJ | EGFR | Tyr1069 | EDSFLQRySSDPTGA | dephosphorylation up-regulates quantity by stabilization | 19836242 | SIGNOR-248697 |
| PTPRG | EGFR | Tyr1069 | EDSFLQRySSDPTGA | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254699 |
| JAK2 | EGFR | Tyr1069 | EDSFLQRySSDPTGA | phosphorylation up-regulates activity | 9363897 | SIGNOR-251347 |
| EGFR | EGFR | Tyr1069 | EDSFLQRySSDPTGA | phosphorylation up-regulates activity | 10635327 | SIGNOR-251093 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRJ | dephosphorylation down-regulates ⊣ | EGFR PTyr1069 | dephosphorylation down-regulates ⊣ | EGFR | 19836242 | SIGNOR-248697 |
| PTPRG | dephosphorylation down-regulates ⊣ | EGFR PTyr1069 | dephosphorylation up-regulates → | EGFR | 25624455 | SIGNOR-254699 |
| JAK2 | phosphorylation up-regulates → | EGFR PTyr1069 | phosphorylation up-regulates → | EGFR | 9363897 | SIGNOR-251347 |
| EGFR | phosphorylation up-regulates → | EGFR PTyr1069 | phosphorylation up-regulates → | EGFR | 10635327 | SIGNOR-251093 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPRJ | dephosphorylation → up-regulates quantity by stabilization | EGFR | SIGNOR-248697 |
| PTPRG | dephosphorylation → down-regulates activity | EGFR | SIGNOR-254699 |
| JAK2 | phosphorylation → up-regulates activity | EGFR | SIGNOR-251347 |
| EGFR | phosphorylation → up-regulates activity | EGFR | SIGNOR-251093 |
