| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AXL | EGFR | Tyr1197 | STAENAEyLRVAPQS | phosphorylation up-regulates activity | 25873175 | SIGNOR-279141 |
| EGFR | EGFR | Tyr1197 | STAENAEyLRVAPQS | phosphorylation up-regulates activity | 16122376 | SIGNOR-235951 |
| ABL1 | EGFR | Tyr1197 | STAENAEyLRVAPQS | phosphorylation up-regulates | 16943190 | SIGNOR-149277 |
| PTPRK | EGFR | Tyr1197 | STAENAEyLRVAPQS | dephosphorylation unknown | 16263724 | SIGNOR-248723 |
| EGFR | EGFR | Tyr1197 | STAENAEyLRVAPQS | phosphorylation up-regulates activity | 10653583 | SIGNOR-236471 |
| PTPRJ | EGFR | Tyr1197 | STAENAEyLRVAPQS | dephosphorylation up-regulates quantity by stabilization | 19836242 | SIGNOR-248699 |
| ERBB2 | EGFR | Tyr1197 | STAENAEyLRVAPQS | phosphorylation up-regulates activity | 23027125 | SIGNOR-278474 |
| PTPN6 | EGFR | Tyr1197 | STAENAEyLRVAPQS | dephosphorylation down-regulates | 9733788 | SIGNOR-59965 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AXL | phosphorylation up-regulates → | EGFR PTyr1197 | phosphorylation up-regulates → | EGFR | 25873175 | SIGNOR-279141 |
| EGFR | phosphorylation up-regulates → | EGFR PTyr1197 | phosphorylation up-regulates → | EGFR | 16122376 | SIGNOR-235951 |
| ABL1 | phosphorylation up-regulates → | EGFR PTyr1197 | phosphorylation up-regulates → | EGFR | 16943190 | SIGNOR-149277 |
| PTPRK | dephosphorylation down-regulates ⊣ | EGFR PTyr1197 | dephosphorylation up-regulates → | EGFR | 16263724 | SIGNOR-248723 |
| EGFR | phosphorylation up-regulates → | EGFR PTyr1197 | phosphorylation up-regulates → | EGFR | 10653583 | SIGNOR-236471 |
| PTPRJ | dephosphorylation down-regulates ⊣ | EGFR PTyr1197 | dephosphorylation down-regulates ⊣ | EGFR | 19836242 | SIGNOR-248699 |
| ERBB2 | phosphorylation up-regulates → | EGFR PTyr1197 | phosphorylation up-regulates → | EGFR | 23027125 | SIGNOR-278474 |
| PTPN6 | dephosphorylation down-regulates ⊣ | EGFR PTyr1197 | dephosphorylation up-regulates → | EGFR | 9733788 | SIGNOR-59965 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AXL | phosphorylation → up-regulates activity | EGFR | SIGNOR-279141 |
| EGFR | phosphorylation → up-regulates activity | EGFR | SIGNOR-235951 |
| ABL1 | phosphorylation → up-regulates | EGFR | SIGNOR-149277 |
| PTPRK | dephosphorylation → unknown | EGFR | SIGNOR-248723 |
| EGFR | phosphorylation → up-regulates activity | EGFR | SIGNOR-236471 |
| PTPRJ | dephosphorylation → up-regulates quantity by stabilization | EGFR | SIGNOR-248699 |
| ERBB2 | phosphorylation → up-regulates activity | EGFR | SIGNOR-278474 |
| PTPN6 | dephosphorylation down-regulates | EGFR | SIGNOR-59965 |
