| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN1 | EGFR | Tyr1016 | DVVDADEyLIPQQGF | dephosphorylation down-regulates activity | 8621392 | SIGNOR-248407 |
| EGFR | EGFR | Tyr1016 | DVVDADEyLIPQQGF | phosphorylation up-regulates activity | 10653583 | SIGNOR-236475 |
| DUSP3 | EGFR | Tyr1016 | DVVDADEyLIPQQGF | dephosphorylation down-regulates activity | 21262974 | SIGNOR-248532 |
| PTPN11 | EGFR | Tyr1016 | DVVDADEyLIPQQGF | dephosphorylation down-regulates activity | 14560030 | SIGNOR-248666 |
| EGFR | EGFR | Tyr1016 | DVVDADEyLIPQQGF | phosphorylation up-regulates activity | 16122376 | SIGNOR-236527 |
| PTPN11 | EGFR | Tyr1016 | DVVDADEyLIPQQGF | dephosphorylation down-regulates activity | 12582165 | SIGNOR-236424 |
| SRC | EGFR | Tyr1016 | DVVDADEyLIPQQGF | phosphorylation up-regulates activity | 8845374 | SIGNOR-44239 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN1 | dephosphorylation down-regulates ⊣ | EGFR PTyr1016 | dephosphorylation up-regulates → | EGFR | 8621392 | SIGNOR-248407 |
| EGFR | phosphorylation up-regulates → | EGFR PTyr1016 | phosphorylation up-regulates → | EGFR | 10653583 | SIGNOR-236475 |
| DUSP3 | dephosphorylation down-regulates ⊣ | EGFR PTyr1016 | dephosphorylation up-regulates → | EGFR | 21262974 | SIGNOR-248532 |
| PTPN11 | dephosphorylation down-regulates ⊣ | EGFR PTyr1016 | dephosphorylation up-regulates → | EGFR | 14560030 | SIGNOR-248666 |
| EGFR | phosphorylation up-regulates → | EGFR PTyr1016 | phosphorylation up-regulates → | EGFR | 16122376 | SIGNOR-236527 |
| PTPN11 | dephosphorylation down-regulates ⊣ | EGFR PTyr1016 | dephosphorylation up-regulates → | EGFR | 12582165 | SIGNOR-236424 |
| SRC | phosphorylation up-regulates → | EGFR PTyr1016 | phosphorylation up-regulates → | EGFR | 8845374 | SIGNOR-44239 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN1 | dephosphorylation → down-regulates activity | EGFR | SIGNOR-248407 |
| EGFR | phosphorylation → up-regulates activity | EGFR | SIGNOR-236475 |
| DUSP3 | dephosphorylation → down-regulates activity | EGFR | SIGNOR-248532 |
| PTPN11 | dephosphorylation → down-regulates activity | EGFR | SIGNOR-248666 |
| EGFR | phosphorylation → up-regulates activity | EGFR | SIGNOR-236527 |
| PTPN11 | dephosphorylation → down-regulates activity | EGFR | SIGNOR-236424 |
| SRC | phosphorylation → up-regulates activity | EGFR | SIGNOR-44239 |
