| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LYN | EGFR | Tyr1125 | APSRDPHyQDPHSTA | phosphorylation up-regulates activity | 22430206 | SIGNOR-279205 |
| SRC | EGFR | Tyr1125 | APSRDPHyQDPHSTA | phosphorylation up-regulates | 8845374 | SIGNOR-44247 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LYN | phosphorylation up-regulates → | EGFR PTyr1125 | phosphorylation up-regulates → | EGFR | 22430206 | SIGNOR-279205 |
| SRC | phosphorylation up-regulates → | EGFR PTyr1125 | phosphorylation up-regulates → | EGFR | 8845374 | SIGNOR-44247 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| LYN | phosphorylation → up-regulates activity | EGFR | SIGNOR-279205 |
| SRC | phosphorylation → up-regulates | EGFR | SIGNOR-44247 |
