| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EGFR | EGFR | Tyr1172 | ISLDNPDyQQDFFPK | phosphorylation up-regulates activity | 10653583 | SIGNOR-236467 |
| ABL1 | EGFR | Tyr1172 | ISLDNPDyQQDFFPK | phosphorylation up-regulates | 16943190 | SIGNOR-149273 |
| EGFR | EGFR | Tyr1172 | ISLDNPDyQQDFFPK | phosphorylation up-regulates activity | 16122376 | SIGNOR-236531 |
| SRC | EGFR | Tyr1172 | ISLDNPDyQQDFFPK | phosphorylation up-regulates activity | 8845374 | SIGNOR-44251 |
| PTPRG | EGFR | Tyr1172 | ISLDNPDyQQDFFPK | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254700 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EGFR | phosphorylation up-regulates → | EGFR PTyr1172 | phosphorylation up-regulates → | EGFR | 10653583 | SIGNOR-236467 |
| ABL1 | phosphorylation up-regulates → | EGFR PTyr1172 | phosphorylation up-regulates → | EGFR | 16943190 | SIGNOR-149273 |
| EGFR | phosphorylation up-regulates → | EGFR PTyr1172 | phosphorylation up-regulates → | EGFR | 16122376 | SIGNOR-236531 |
| SRC | phosphorylation up-regulates → | EGFR PTyr1172 | phosphorylation up-regulates → | EGFR | 8845374 | SIGNOR-44251 |
| PTPRG | dephosphorylation down-regulates ⊣ | EGFR PTyr1172 | dephosphorylation down-regulates ⊣ | EGFR | 25624455 | SIGNOR-254700 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| EGFR | phosphorylation → up-regulates activity | EGFR | SIGNOR-236467 |
| ABL1 | phosphorylation → up-regulates | EGFR | SIGNOR-149273 |
| EGFR | phosphorylation → up-regulates activity | EGFR | SIGNOR-236531 |
| SRC | phosphorylation → up-regulates activity | EGFR | SIGNOR-44251 |
| PTPRG | dephosphorylation → up-regulates activity | EGFR | SIGNOR-254700 |
