| Name | MYC |
| ID | P01106 |
| Role | substrate |
| Enzymatic Domains |
bHLH 369-421 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK9 | MYC | Ser62 | S-->E | phosphorylation down-regulates activity | 31311847 | SIGNOR-279024 |
| PAK2 | MYC | Thr358 | ISNNRKCtSPRSSDT | phosphorylation down-regulates activity | 14749374 | SIGNOR-278489 |
| DYRK1A | MYC | Ser62 | S-->E | phosphorylation down-regulates quantity | 24901999 | SIGNOR-279609 |
| PLK1 | MYC | – | phosphorylation up-regulates activity | 23887393 | SIGNOR-243522 | |
| AURKB | MYC | Ser67 | S-->K | phosphorylation up-regulates quantity by stabilization | 32049046 | SIGNOR-279439 |
| PPP2CB | MYC | Ser62 | LLPTPPLsPSRRSGL | dephosphorylation down-regulates | 16987807 | SIGNOR-149726 |
| CSNK2A1 | MYC | Ser267 | PPTTSSDsEEEQEDE | phosphorylation down-regulates quantity by destabilization | 22025562 | SIGNOR-276388 |
| PIM1 | MYC | Ser62 | S-->E | phosphorylation up-regulates quantity by stabilization | 29472550 | SIGNOR-279249 |
| GSK3A | MYC | Thr58 | KKFELLPtPPLSPSR | phosphorylation down-regulates quantity by destabilization | 16023596 | SIGNOR-138596 |
| GSK3B | MYC | Thr58 | KKFELLPtPPLSPSR | phosphorylation down-regulates quantity by destabilization | 11018017 | SIGNOR-252080 |
| MAPK8 | MYC | Ser71 | SRRSGLCsPSYVAVT | phosphorylation up-regulates activity | 10551811 | SIGNOR-236384 |
| MAPK1 | MYC | Ser62 | LLPTPPLsPSRRSGL | phosphorylation up-regulates activity | 8386367 | SIGNOR-235700 |
| PAK2 | MYC | Thr400 | T-->E | phosphorylation down-regulates activity | 14749374 | SIGNOR-278490 |
| MAPK3 | MYC | Ser62 | LLPTPPLsPSRRSGL | phosphorylation up-regulates activity | 32482868 | SIGNOR-236250 |
| GSK3B | MYC | Thr58 | KKFELLPtPPLSPSR | phosphorylation down-regulates quantity by destabilization | 16023596 | SIGNOR-138603 |
| PIM1 | MYC | – | phosphorylation up-regulates activity | 25280219 | SIGNOR-261557 | |
| GSK3B | MYC | Thr58 | KKFELLPtPPLSPSR | phosphorylation down-regulates quantity by destabilization | 14563837 | SIGNOR-118844 |
| CSNK1A1 | MYC | Ser267 | PPTTSSDsEEEQEDE | phosphorylation down-regulates quantity by destabilization | 22025562 | SIGNOR-276387 |
| BRD4 | MYC | Thr58 | KKFELLPtPPLSPSR | phosphorylation down-regulates quantity by destabilization | 32482868 | SIGNOR-262046 |
| CDK2 | MYC | Ser62 | S-->E | phosphorylation up-regulates quantity by stabilization | 35039060 | SIGNOR-279808 |
| ERK1/2 | MYC | Ser62 | LLPTPPLsPSRRSGL | phosphorylation up-regulates quantity by stabilization | 11018017 | SIGNOR-252079 |
| STK38 | MYC | – | phosphorylation down-regulates activity | 23178486 | SIGNOR-280142 | |
| MAPK8 | MYC | Ser62 | LLPTPPLsPSRRSGL | phosphorylation up-regulates activity | 10551811 | SIGNOR-236018 |
| MAPK9 | MYC | Ser62 | LLPTPPLsPSRRSGL | phosphorylation up-regulates | 10551811 | SIGNOR-72104 |
| MAPK9 | MYC | Ser71 | SRRSGLCsPSYVAVT | phosphorylation up-regulates | 10551811 | SIGNOR-72108 |
| Gbeta | MYC | – | phosphorylation up-regulates activity | 32482868 | SIGNOR-270030 | |
| ABL1 | MYC | Tyr74 | Y-->P | phosphorylation up-regulates activity | 23318434 | SIGNOR-278196 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK9 | phosphorylation up-regulates → | MYC PSer62 | phosphorylation down-regulates ⊣ | MYC | 31311847 | SIGNOR-279024 |
| PAK2 | phosphorylation up-regulates → | MYC PThr358 | phosphorylation down-regulates ⊣ | MYC | 14749374 | SIGNOR-278489 |
| DYRK1A | phosphorylation up-regulates → | MYC PSer62 | phosphorylation down-regulates ⊣ | MYC | 24901999 | SIGNOR-279609 |
| AURKB | phosphorylation up-regulates → | MYC PSer67 | phosphorylation up-regulates → | MYC | 32049046 | SIGNOR-279439 |
| PPP2CB | dephosphorylation down-regulates ⊣ | MYC PSer62 | dephosphorylation up-regulates → | MYC | 16987807 | SIGNOR-149726 |
| CSNK2A1 | phosphorylation up-regulates → | MYC PSer267 | phosphorylation down-regulates ⊣ | MYC | 22025562 | SIGNOR-276388 |
| PIM1 | phosphorylation up-regulates → | MYC PSer62 | phosphorylation up-regulates → | MYC | 29472550 | SIGNOR-279249 |
| GSK3A | phosphorylation up-regulates → | MYC PThr58 | phosphorylation down-regulates ⊣ | MYC | 16023596 | SIGNOR-138596 |
| GSK3B | phosphorylation up-regulates → | MYC PThr58 | phosphorylation down-regulates ⊣ | MYC | 11018017 | SIGNOR-252080 |
| MAPK8 | phosphorylation up-regulates → | MYC PSer71 | phosphorylation up-regulates → | MYC | 10551811 | SIGNOR-236384 |
| MAPK1 | phosphorylation up-regulates → | MYC PSer62 | phosphorylation up-regulates → | MYC | 8386367 | SIGNOR-235700 |
| PAK2 | phosphorylation up-regulates → | MYC PThr400 | phosphorylation down-regulates ⊣ | MYC | 14749374 | SIGNOR-278490 |
| MAPK3 | phosphorylation up-regulates → | MYC PSer62 | phosphorylation up-regulates → | MYC | 32482868 | SIGNOR-236250 |
| GSK3B | phosphorylation up-regulates → | MYC PThr58 | phosphorylation down-regulates ⊣ | MYC | 16023596 | SIGNOR-138603 |
| GSK3B | phosphorylation up-regulates → | MYC PThr58 | phosphorylation down-regulates ⊣ | MYC | 14563837 | SIGNOR-118844 |
| CSNK1A1 | phosphorylation up-regulates → | MYC PSer267 | phosphorylation down-regulates ⊣ | MYC | 22025562 | SIGNOR-276387 |
| BRD4 | phosphorylation up-regulates → | MYC PThr58 | phosphorylation down-regulates ⊣ | MYC | 32482868 | SIGNOR-262046 |
| CDK2 | phosphorylation up-regulates → | MYC PSer62 | phosphorylation up-regulates → | MYC | 35039060 | SIGNOR-279808 |
| ERK1/2 | phosphorylation up-regulates → | MYC PSer62 | phosphorylation up-regulates → | MYC | 11018017 | SIGNOR-252079 |
| MAPK8 | phosphorylation up-regulates → | MYC PSer62 | phosphorylation up-regulates → | MYC | 10551811 | SIGNOR-236018 |
| MAPK9 | phosphorylation up-regulates → | MYC PSer62 | phosphorylation up-regulates → | MYC | 10551811 | SIGNOR-72104 |
| MAPK9 | phosphorylation up-regulates → | MYC PSer71 | phosphorylation up-regulates → | MYC | 10551811 | SIGNOR-72108 |
| ABL1 | phosphorylation up-regulates → | MYC PTyr74 | phosphorylation up-regulates → | MYC | 23318434 | SIGNOR-278196 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK9 | phosphorylation → down-regulates activity | MYC | SIGNOR-279024 |
| PAK2 | phosphorylation → down-regulates activity | MYC | SIGNOR-278489 |
| DYRK1A | phosphorylation → down-regulates quantity | MYC | SIGNOR-279609 |
| PLK1 | phosphorylation → up-regulates activity | MYC | SIGNOR-243522 |
| AURKB | phosphorylation → up-regulates quantity by stabilization | MYC | SIGNOR-279439 |
| PPP2CB | dephosphorylation down-regulates | MYC | SIGNOR-149726 |
| CSNK2A1 | phosphorylation down-regulates quantity by destabilization | MYC | SIGNOR-276388 |
| PIM1 | phosphorylation → up-regulates quantity by stabilization | MYC | SIGNOR-279249 |
| GSK3A | phosphorylation down-regulates quantity by destabilization | MYC | SIGNOR-138596 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | MYC | SIGNOR-252080 |
| MAPK8 | phosphorylation → up-regulates activity | MYC | SIGNOR-236384 |
| MAPK1 | phosphorylation → up-regulates activity | MYC | SIGNOR-235700 |
| PAK2 | phosphorylation → down-regulates activity | MYC | SIGNOR-278490 |
| MAPK3 | phosphorylation → up-regulates activity | MYC | SIGNOR-236250 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | MYC | SIGNOR-138603 |
| PIM1 | phosphorylation → up-regulates activity | MYC | SIGNOR-261557 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | MYC | SIGNOR-118844 |
| CSNK1A1 | phosphorylation down-regulates quantity by destabilization | MYC | SIGNOR-276387 |
| BRD4 | phosphorylation down-regulates quantity by destabilization | MYC | SIGNOR-262046 |
| CDK2 | phosphorylation → up-regulates quantity by stabilization | MYC | SIGNOR-279808 |
| ERK1/2 | phosphorylation → up-regulates quantity by stabilization | MYC | SIGNOR-252079 |
| STK38 | phosphorylation → down-regulates activity | MYC | SIGNOR-280142 |
| MAPK8 | phosphorylation → up-regulates activity | MYC | SIGNOR-236018 |
| MAPK9 | phosphorylation → up-regulates | MYC | SIGNOR-72104 |
| MAPK9 | phosphorylation → up-regulates | MYC | SIGNOR-72108 |
| Gbeta | phosphorylation → up-regulates activity | MYC | SIGNOR-270030 |
| ABL1 | phosphorylation → up-regulates activity | MYC | SIGNOR-278196 |