| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3A | MYC | Thr58 | KKFELLPtPPLSPSR | phosphorylation down-regulates quantity by destabilization | 16023596 | SIGNOR-138596 |
| GSK3B | MYC | Thr58 | KKFELLPtPPLSPSR | phosphorylation down-regulates quantity by destabilization | 11018017 | SIGNOR-252080 |
| RNF115 | MYC | Thr58 | T-->P | ubiquitination down-regulates quantity by destabilization | 22844532 | SIGNOR-278662 |
| BRD4 | MYC | Thr58 | KKFELLPtPPLSPSR | phosphorylation down-regulates quantity by destabilization | 32482868 | SIGNOR-262046 |
| GSK3B | MYC | Thr58 | KKFELLPtPPLSPSR | phosphorylation down-regulates quantity by destabilization | 16023596 | SIGNOR-138603 |
| GSK3B | MYC | Thr58 | KKFELLPtPPLSPSR | phosphorylation down-regulates quantity by destabilization | 14563837 | SIGNOR-118844 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3A | phosphorylation up-regulates → | MYC PThr58 | phosphorylation down-regulates ⊣ | MYC | 16023596 | SIGNOR-138596 |
| GSK3B | phosphorylation up-regulates → | MYC PThr58 | phosphorylation down-regulates ⊣ | MYC | 11018017 | SIGNOR-252080 |
| RNF115 | ubiquitination up-regulates → | MYC PThr58 | ubiquitination down-regulates ⊣ | MYC | 22844532 | SIGNOR-278662 |
| BRD4 | phosphorylation up-regulates → | MYC PThr58 | phosphorylation down-regulates ⊣ | MYC | 32482868 | SIGNOR-262046 |
| GSK3B | phosphorylation up-regulates → | MYC PThr58 | phosphorylation down-regulates ⊣ | MYC | 16023596 | SIGNOR-138603 |
| GSK3B | phosphorylation up-regulates → | MYC PThr58 | phosphorylation down-regulates ⊣ | MYC | 14563837 | SIGNOR-118844 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GSK3A | phosphorylation down-regulates quantity by destabilization | MYC | SIGNOR-138596 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | MYC | SIGNOR-252080 |
| RNF115 | ubiquitination down-regulates quantity by destabilization | MYC | SIGNOR-278662 |
| BRD4 | phosphorylation down-regulates quantity by destabilization | MYC | SIGNOR-262046 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | MYC | SIGNOR-138603 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | MYC | SIGNOR-118844 |
