| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK9 | MYC | Ser62 | LLPTPPLsPSRRSGL | phosphorylation up-regulates | 10551811 | SIGNOR-72104 |
| PPP2CB | MYC | Ser62 | LLPTPPLsPSRRSGL | dephosphorylation down-regulates | 16987807 | SIGNOR-149726 |
| DYRK1A | MYC | Ser62 | S-->E | phosphorylation down-regulates quantity | 24901999 | SIGNOR-279609 |
| MAPK8 | MYC | Ser62 | LLPTPPLsPSRRSGL | phosphorylation up-regulates activity | 10551811 | SIGNOR-236018 |
| MAPK3 | MYC | Ser62 | LLPTPPLsPSRRSGL | phosphorylation up-regulates activity | 32482868 | SIGNOR-236250 |
| CDK9 | MYC | Ser62 | S-->E | phosphorylation down-regulates activity | 31311847 | SIGNOR-279024 |
| ERK1/2 | MYC | Ser62 | LLPTPPLsPSRRSGL | phosphorylation up-regulates quantity by stabilization | 11018017 | SIGNOR-252079 |
| CDK2 | MYC | Ser62 | S-->E | phosphorylation up-regulates quantity by stabilization | 35039060 | SIGNOR-279808 |
| PIM1 | MYC | Ser62 | S-->E | phosphorylation up-regulates quantity by stabilization | 29472550 | SIGNOR-279249 |
| MAPK1 | MYC | Ser62 | LLPTPPLsPSRRSGL | phosphorylation up-regulates activity | 8386367 | SIGNOR-235700 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK9 | phosphorylation up-regulates → | MYC PSer62 | phosphorylation up-regulates → | MYC | 10551811 | SIGNOR-72104 |
| PPP2CB | dephosphorylation down-regulates ⊣ | MYC PSer62 | dephosphorylation up-regulates → | MYC | 16987807 | SIGNOR-149726 |
| DYRK1A | phosphorylation up-regulates → | MYC PSer62 | phosphorylation down-regulates ⊣ | MYC | 24901999 | SIGNOR-279609 |
| MAPK8 | phosphorylation up-regulates → | MYC PSer62 | phosphorylation up-regulates → | MYC | 10551811 | SIGNOR-236018 |
| MAPK3 | phosphorylation up-regulates → | MYC PSer62 | phosphorylation up-regulates → | MYC | 32482868 | SIGNOR-236250 |
| CDK9 | phosphorylation up-regulates → | MYC PSer62 | phosphorylation down-regulates ⊣ | MYC | 31311847 | SIGNOR-279024 |
| ERK1/2 | phosphorylation up-regulates → | MYC PSer62 | phosphorylation up-regulates → | MYC | 11018017 | SIGNOR-252079 |
| CDK2 | phosphorylation up-regulates → | MYC PSer62 | phosphorylation up-regulates → | MYC | 35039060 | SIGNOR-279808 |
| PIM1 | phosphorylation up-regulates → | MYC PSer62 | phosphorylation up-regulates → | MYC | 29472550 | SIGNOR-279249 |
| MAPK1 | phosphorylation up-regulates → | MYC PSer62 | phosphorylation up-regulates → | MYC | 8386367 | SIGNOR-235700 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK9 | phosphorylation → up-regulates | MYC | SIGNOR-72104 |
| PPP2CB | dephosphorylation down-regulates | MYC | SIGNOR-149726 |
| DYRK1A | phosphorylation → down-regulates quantity | MYC | SIGNOR-279609 |
| MAPK8 | phosphorylation → up-regulates activity | MYC | SIGNOR-236018 |
| MAPK3 | phosphorylation → up-regulates activity | MYC | SIGNOR-236250 |
| CDK9 | phosphorylation → down-regulates activity | MYC | SIGNOR-279024 |
| ERK1/2 | phosphorylation → up-regulates quantity by stabilization | MYC | SIGNOR-252079 |
| CDK2 | phosphorylation → up-regulates quantity by stabilization | MYC | SIGNOR-279808 |
| PIM1 | phosphorylation → up-regulates quantity by stabilization | MYC | SIGNOR-279249 |
| MAPK1 | phosphorylation → up-regulates activity | MYC | SIGNOR-235700 |
