| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN11 | NRAS | Tyr32 | QNHFVDEyDPTIEDS | dephosphorylation up-regulates activity | 26617336 | SIGNOR-255754 |
| STK19 | NRAS | Ser89 | FAINNSKsFADINLY | phosphorylation up-regulates activity | 30712867 | SIGNOR-264566 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN11 | dephosphorylation down-regulates ⊣ | NRAS PTyr32 | dephosphorylation down-regulates ⊣ | NRAS | 26617336 | SIGNOR-255754 |
| STK19 | phosphorylation up-regulates → | NRAS PSer89 | phosphorylation up-regulates → | NRAS | 30712867 | SIGNOR-264566 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN11 | dephosphorylation → up-regulates activity | NRAS | SIGNOR-255754 |
| STK19 | phosphorylation → up-regulates activity | NRAS | SIGNOR-264566 |
