| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN11 | HRAS | Tyr32 | QNHFVDEyDPTIEDS | dephosphorylation up-regulates activity | 26617336 | SIGNOR-252094 |
| SRC | HRAS | Tyr32 | QNHFVDEyDPTIEDS | phosphorylation down-regulates activity | 25157176 | SIGNOR-252093 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN11 | dephosphorylation down-regulates ⊣ | HRAS PTyr32 | dephosphorylation down-regulates ⊣ | HRAS | 26617336 | SIGNOR-252094 |
| SRC | phosphorylation up-regulates → | HRAS PTyr32 | phosphorylation down-regulates ⊣ | HRAS | 25157176 | SIGNOR-252093 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN11 | dephosphorylation → up-regulates activity | HRAS | SIGNOR-252094 |
| SRC | phosphorylation → down-regulates activity | HRAS | SIGNOR-252093 |
