| Name | LMNA |
| ID | P02545 |
| Role | substrate |
| Enzymatic Domains |
IF rod 31-387 PROSITE-ProRule
LTD 428-545 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | LMNA | Ser390 | EEERLRLsPSPTSQR | phosphorylation up-regulates | 18815303 | SIGNOR-181314 |
| CDK1 | LMNA | Ser22 | QASSTPLsPTRITRL | phosphorylation up-regulates | 18815303 | SIGNOR-181310 |
| PRKCA | LMNA | Ser404 | RSRGRASsHSSQTQG | phosphorylation up-regulates activity | 7925482 | SIGNOR-248904 |
| PRKCA | LMNA | Ser525 | NTWGCGNsLRTALIN | phosphorylation unknown | 8477740 | SIGNOR-248935 |
| PRKCA | LMNA | Ser403 | QRSRGRAsSHSSQTQ | phosphorylation up-regulates activity | 7925482 | SIGNOR-248903 |
| SRC | LMNA | Tyr45 | LNDRLAVyIDRVRSL | phosphorylation up-regulates activity | 34385357 | SIGNOR-279288 |
| CDK1 | LMNA | Ser392 | ERLRLSPsPTSQRSR | phosphorylation up-regulates | 18815303 | SIGNOR-181318 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | phosphorylation up-regulates → | LMNA PSer390 | phosphorylation up-regulates → | LMNA | 18815303 | SIGNOR-181314 |
| CDK1 | phosphorylation up-regulates → | LMNA PSer22 | phosphorylation up-regulates → | LMNA | 18815303 | SIGNOR-181310 |
| PRKCA | phosphorylation up-regulates → | LMNA PSer404 | phosphorylation up-regulates → | LMNA | 7925482 | SIGNOR-248904 |
| PRKCA | phosphorylation up-regulates → | LMNA PSer525 | phosphorylation down-regulates ⊣ | LMNA | 8477740 | SIGNOR-248935 |
| PRKCA | phosphorylation up-regulates → | LMNA PSer403 | phosphorylation up-regulates → | LMNA | 7925482 | SIGNOR-248903 |
| SRC | phosphorylation up-regulates → | LMNA PTyr45 | phosphorylation up-regulates → | LMNA | 34385357 | SIGNOR-279288 |
| CDK1 | phosphorylation up-regulates → | LMNA PSer392 | phosphorylation up-regulates → | LMNA | 18815303 | SIGNOR-181318 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK1 | phosphorylation → up-regulates | LMNA | SIGNOR-181314 |
| CDK1 | phosphorylation → up-regulates | LMNA | SIGNOR-181310 |
| PRKCA | phosphorylation → up-regulates activity | LMNA | SIGNOR-248904 |
| PRKCA | phosphorylation → unknown | LMNA | SIGNOR-248935 |
| PRKCA | phosphorylation → up-regulates activity | LMNA | SIGNOR-248903 |
| SRC | phosphorylation → up-regulates activity | LMNA | SIGNOR-279288 |
| CDK1 | phosphorylation → up-regulates | LMNA | SIGNOR-181318 |