| Name | ESR1 |
| ID | P03372 |
| Role | substrate |
| Enzymatic Domains |
NR LBD 311-547 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6K | ESR1 | Ser167 | GGRERLAsTNDKGSM | phosphorylation up-regulates | 7838153 | SIGNOR-252807 |
| MAPK1 | ESR1 | Ser106 | PLNSVSPsPLMLLHP | phosphorylation up-regulates | 17615152 | SIGNOR-156852 |
| MAPK3 | ESR1 | Ser106 | PLNSVSPsPLMLLHP | phosphorylation up-regulates | 17615152 | SIGNOR-156864 |
| AKT | ESR1 | Ser118 | LHPPPQLsPFLQPHG | phosphorylation up-regulates | 11108261 | SIGNOR-244255 |
| AKT | ESR1 | Ser106 | PLNSVSPsPLMLLHP | phosphorylation up-regulates | 11108261 | SIGNOR-244247 |
| MNAT1 | ESR1 | Ser118 | LHPPPQLsPFLQPHG | phosphorylation up-regulates activity | 10949034 | SIGNOR-260837 |
| MAPK1 | ESR1 | Ser106 | PLNSVSPsPLMLLHP | phosphorylation up-regulates | 18372406 | SIGNOR-178137 |
| CyclinA2/CDK2 | ESR1 | Ser106 | PLNSVSPsPLMLLHP | phosphorylation up-regulates | 10428798 | SIGNOR-217288 |
| ERK1/2 | ESR1 | Ser118 | LHPPPQLsPFLQPHG | phosphorylation up-regulates | 17615152 | SIGNOR-244655 |
| SRC | ESR1 | Tyr537 | CKNVVPLyDLLLEML | phosphorylation up-regulates | 9500442 | SIGNOR-55857 |
| MAPK1 | ESR1 | Ser104 | FPPLNSVsPSPLMLL | phosphorylation up-regulates | 17615152 | SIGNOR-156848 |
| AKT | ESR1 | Ser104 | FPPLNSVsPSPLMLL | phosphorylation up-regulates | 11108261 | SIGNOR-244243 |
| MAPK14 | ESR1 | Ser118 | LHPPPQLsPFLQPHG | phosphorylation up-regulates | 15879307 | SIGNOR-136950 |
| PRKACA | ESR1 | Ser305 | IKRSKKNsLALSLTA | phosphorylation up-regulates | 15193262 | SIGNOR-125779 |
| AURKA | ESR1 | Ser305 | IKRSKKNsLALSLTA | phosphorylation up-regulates activity | 24166501 | SIGNOR-278507 |
| AURKA | ESR1 | Ser167 | GGRERLAsTNDKGSM | phosphorylation up-regulates activity | 24166501 | SIGNOR-278508 |
| PAK4 | ESR1 | Ser305 | IKRSKKNsLALSLTA | phosphorylation up-regulates activity | 26554417 | SIGNOR-279472 |
| CyclinA2/CDK2 | ESR1 | Ser118 | LHPPPQLsPFLQPHG | phosphorylation up-regulates | 10428798 | SIGNOR-217292 |
| CDK2 | ESR1 | Ser106 | PLNSVSPsPLMLLHP | phosphorylation up-regulates | 10428798 | SIGNOR-69714 |
| PTPN3 | ESR1 | Tyr537 | CKNVVPLyDLLLEML | dephosphorylation up-regulates activity | 26079946 | SIGNOR-277127 |
| AKT1 | ESR1 | Ser118 | LHPPPQLsPFLQPHG | phosphorylation up-regulates | 11108261 | SIGNOR-84971 |
| AKT1 | ESR1 | Ser106 | PLNSVSPsPLMLLHP | phosphorylation up-regulates | 11108261 | SIGNOR-84967 |
| ERK1/2 | ESR1 | Ser106 | PLNSVSPsPLMLLHP | phosphorylation up-regulates | 17615152 | SIGNOR-244651 |
| GSK3B | ESR1 | Ser104 | FPPLNSVsPSPLMLL | phosphorylation up-regulates | 16076840 | SIGNOR-139316 |
| MAPK1 | ESR1 | Ser118 | LHPPPQLsPFLQPHG | phosphorylation up-regulates | 12466266 | SIGNOR-96072 |
| GSK3B | ESR1 | Ser118 | LHPPPQLsPFLQPHG | phosphorylation up-regulates | 16076840 | SIGNOR-139324 |
| DUSP22 | ESR1 | Ser118 | LHPPPQLsPFLQPHG | dephosphorylation down-regulates activity | 17384676 | SIGNOR-248827 |
| LCK | ESR1 | Tyr537 | CKNVVPLyDLLLEML | phosphorylation up-regulates | 10571988 | SIGNOR-72373 |
| PAK1 | ESR1 | Ser305 | IKRSKKNsLALSLTA | phosphorylation up-regulates | 12374744 | SIGNOR-94206 |
| Gbeta | ESR1 | – | phosphorylation up-regulates | 17615152 | SIGNOR-270023 | |
| ERBB2 | ESR1 | – | phosphorylation up-regulates | 15173068 | SIGNOR-124962 | |
| ABL1 | ESR1 | Tyr52 | DSSKPAVyNYPEGAA | phosphorylation up-regulates | 20101225 | SIGNOR-163566 |
| PRKDC | ESR1 | Ser118 | LHPPPQLsPFLQPHG | phosphorylation up-regulates quantity by stabilization | 20219974 | SIGNOR-279561 |
| MTOR | ESR1 | – | phosphorylation up-regulates activity | 26522726 | SIGNOR-278295 | |
| MAPK3 | ESR1 | Ser104 | FPPLNSVsPSPLMLL | phosphorylation up-regulates | 17615152 | SIGNOR-156860 |
| MAPK1 | ESR1 | Ser104 | FPPLNSVsPSPLMLL | phosphorylation up-regulates | 18372406 | SIGNOR-178133 |
| CSNK2A1 | ESR1 | Ser559 | PTSRGGAsVEETDQS | phosphorylation down-regulates | 20043841 | SIGNOR-162657 |
| GSK3B | ESR1 | Ser102 | GGFPPLNsVSPSPLM | phosphorylation up-regulates | 16076840 | SIGNOR-139312 |
| MAPK3 | ESR1 | Ser106 | PLNSVSPsPLMLLHP | phosphorylation up-regulates | 18372406 | SIGNOR-178145 |
| CDK2 | ESR1 | Ser104 | FPPLNSVsPSPLMLL | phosphorylation up-regulates | 10428798 | SIGNOR-69710 |
| GSK3B | ESR1 | Ser106 | PLNSVSPsPLMLLHP | phosphorylation up-regulates | 16076840 | SIGNOR-139320 |
| LCK | ESR1 | Tyr537 | CKNVVPLyDLLLEML | phosphorylation up-regulates | 9500442 | SIGNOR-55853 |
| IKBKE | ESR1 | Ser167 | GGRERLAsTNDKGSM | phosphorylation up-regulates | 19940156 | SIGNOR-161834 |
| CDK2 | ESR1 | Ser118 | LHPPPQLsPFLQPHG | phosphorylation up-regulates | 10428798 | SIGNOR-69718 |
| GTF2H2 | ESR1 | Ser118 | LHPPPQLsPFLQPHG | phosphorylation up-regulates activity | 10949034 | SIGNOR-260817 |
| AKT | ESR1 | Ser167 | GGRERLAsTNDKGSM | phosphorylation up-regulates | 11108261 | SIGNOR-244251 |
| RPS6KA1 | ESR1 | Ser167 | GGRERLAsTNDKGSM | phosphorylation up-regulates | 7838153 | SIGNOR-34113 |
| MAPK14 | ESR1 | Thr311 | NSLALSLtADQMVSA | phosphorylation up-regulates | 12138194 | SIGNOR-90823 |
| JAK2 | ESR1 | – | phosphorylation down-regulates quantity | 21907792 | SIGNOR-278949 | |
| CSNK2A1 | ESR1 | Ser282 | EGRGEVGsAGDMRAA | phosphorylation down-regulates | 20043841 | SIGNOR-162653 |
| CyclinA2/CDK2 | ESR1 | Ser104 | FPPLNSVsPSPLMLL | phosphorylation up-regulates | 10428798 | SIGNOR-217284 |
| RPS6KB1 | ESR1 | Ser167 | GGRERLAsTNDKGSM | phosphorylation up-regulates | 7838153 | SIGNOR-34117 |
| ABL1 | ESR1 | Tyr219 | SIQGHNDyMCPATNQ | phosphorylation up-regulates | 20101225 | SIGNOR-163562 |
| TFIIH | ESR1 | Ser118 | LHPPPQLsPFLQPHG | phosphorylation up-regulates | 10949034 | SIGNOR-269356 |
| MAPK3 | ESR1 | Ser104 | FPPLNSVsPSPLMLL | phosphorylation up-regulates | 18372406 | SIGNOR-178141 |
| AKT1 | ESR1 | Ser104 | FPPLNSVsPSPLMLL | phosphorylation up-regulates | 11108261 | SIGNOR-84963 |
| CDK2 | ESR1 | Ser294 | RAANLWPsPLMIKRS | phosphorylation up-regulates | 23390529 | SIGNOR-200867 |
| MAPK3 | ESR1 | Ser118 | LHPPPQLsPFLQPHG | phosphorylation up-regulates | 17615152 | SIGNOR-156868 |
| CDK7 | ESR1 | Ser118 | LHPPPQLsPFLQPHG | phosphorylation up-regulates | 10949034 | SIGNOR-81170 |
| CDK3 | ESR1 | Ser118 | LHPPPQLsPFLQPHG | phosphorylation up-regulates activity | 26202215 | SIGNOR-273187 |
| AKT2 | ESR1 | Ser167 | GGRERLAsTNDKGSM | phosphorylation up-regulates activity | 11139588 | SIGNOR-251490 |
| CHUK | ESR1 | Ser118 | LHPPPQLsPFLQPHG | phosphorylation up-regulates activity | 15808510 | SIGNOR-279696 |
| MAPK1 | ESR1 | Ser118 | LHPPPQLsPFLQPHG | phosphorylation up-regulates | 17615152 | SIGNOR-156856 |
| PRKACA | ESR1 | Ser236 | IDKNRRKsCQACRLR | phosphorylation down-regulates | 9891036 | SIGNOR-63984 |
| RPS6KA3 | ESR1 | Ser167 | GGRERLAsTNDKGSM | phosphorylation up-regulates | 19112174 | SIGNOR-182958 |
| EGFR | ESR1 | – | phosphorylation up-regulates | 11887937 | SIGNOR-115734 | |
| CDK3 | ESR1 | Ser104 | FPPLNSVsPSPLMLL | phosphorylation up-regulates activity | 26202215 | SIGNOR-273189 |
| ERK1/2 | ESR1 | Ser104 | FPPLNSVsPSPLMLL | phosphorylation up-regulates | 17615152 | SIGNOR-244647 |
| AKT1 | ESR1 | Ser167 | GGRERLAsTNDKGSM | phosphorylation up-regulates | 11108261 | SIGNOR-84975 |
| CDK3 | ESR1 | Ser106 | PLNSVSPsPLMLLHP | phosphorylation up-regulates activity | 26202215 | SIGNOR-273188 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6K | phosphorylation up-regulates → | ESR1 PSer167 | phosphorylation up-regulates → | ESR1 | 7838153 | SIGNOR-252807 |
| MAPK1 | phosphorylation up-regulates → | ESR1 PSer106 | phosphorylation up-regulates → | ESR1 | 17615152 | SIGNOR-156852 |
| MAPK3 | phosphorylation up-regulates → | ESR1 PSer106 | phosphorylation up-regulates → | ESR1 | 17615152 | SIGNOR-156864 |
| AKT | phosphorylation up-regulates → | ESR1 PSer118 | phosphorylation up-regulates → | ESR1 | 11108261 | SIGNOR-244255 |
| AKT | phosphorylation up-regulates → | ESR1 PSer106 | phosphorylation up-regulates → | ESR1 | 11108261 | SIGNOR-244247 |
| MNAT1 | phosphorylation up-regulates → | ESR1 PSer118 | phosphorylation up-regulates → | ESR1 | 10949034 | SIGNOR-260837 |
| MAPK1 | phosphorylation up-regulates → | ESR1 PSer106 | phosphorylation up-regulates → | ESR1 | 18372406 | SIGNOR-178137 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | ESR1 PSer106 | phosphorylation up-regulates → | ESR1 | 10428798 | SIGNOR-217288 |
| ERK1/2 | phosphorylation up-regulates → | ESR1 PSer118 | phosphorylation up-regulates → | ESR1 | 17615152 | SIGNOR-244655 |
| SRC | phosphorylation up-regulates → | ESR1 PTyr537 | phosphorylation up-regulates → | ESR1 | 9500442 | SIGNOR-55857 |
| MAPK1 | phosphorylation up-regulates → | ESR1 PSer104 | phosphorylation up-regulates → | ESR1 | 17615152 | SIGNOR-156848 |
| AKT | phosphorylation up-regulates → | ESR1 PSer104 | phosphorylation up-regulates → | ESR1 | 11108261 | SIGNOR-244243 |
| MAPK14 | phosphorylation up-regulates → | ESR1 PSer118 | phosphorylation up-regulates → | ESR1 | 15879307 | SIGNOR-136950 |
| PRKACA | phosphorylation up-regulates → | ESR1 PSer305 | phosphorylation up-regulates → | ESR1 | 15193262 | SIGNOR-125779 |
| AURKA | phosphorylation up-regulates → | ESR1 PSer305 | phosphorylation up-regulates → | ESR1 | 24166501 | SIGNOR-278507 |
| AURKA | phosphorylation up-regulates → | ESR1 PSer167 | phosphorylation up-regulates → | ESR1 | 24166501 | SIGNOR-278508 |
| PAK4 | phosphorylation up-regulates → | ESR1 PSer305 | phosphorylation up-regulates → | ESR1 | 26554417 | SIGNOR-279472 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | ESR1 PSer118 | phosphorylation up-regulates → | ESR1 | 10428798 | SIGNOR-217292 |
| CDK2 | phosphorylation up-regulates → | ESR1 PSer106 | phosphorylation up-regulates → | ESR1 | 10428798 | SIGNOR-69714 |
| PTPN3 | dephosphorylation down-regulates ⊣ | ESR1 PTyr537 | dephosphorylation down-regulates ⊣ | ESR1 | 26079946 | SIGNOR-277127 |
| AKT1 | phosphorylation up-regulates → | ESR1 PSer118 | phosphorylation up-regulates → | ESR1 | 11108261 | SIGNOR-84971 |
| AKT1 | phosphorylation up-regulates → | ESR1 PSer106 | phosphorylation up-regulates → | ESR1 | 11108261 | SIGNOR-84967 |
| ERK1/2 | phosphorylation up-regulates → | ESR1 PSer106 | phosphorylation up-regulates → | ESR1 | 17615152 | SIGNOR-244651 |
| GSK3B | phosphorylation up-regulates → | ESR1 PSer104 | phosphorylation up-regulates → | ESR1 | 16076840 | SIGNOR-139316 |
| MAPK1 | phosphorylation up-regulates → | ESR1 PSer118 | phosphorylation up-regulates → | ESR1 | 12466266 | SIGNOR-96072 |
| GSK3B | phosphorylation up-regulates → | ESR1 PSer118 | phosphorylation up-regulates → | ESR1 | 16076840 | SIGNOR-139324 |
| DUSP22 | dephosphorylation down-regulates ⊣ | ESR1 PSer118 | dephosphorylation up-regulates → | ESR1 | 17384676 | SIGNOR-248827 |
| LCK | phosphorylation up-regulates → | ESR1 PTyr537 | phosphorylation up-regulates → | ESR1 | 10571988 | SIGNOR-72373 |
| PAK1 | phosphorylation up-regulates → | ESR1 PSer305 | phosphorylation up-regulates → | ESR1 | 12374744 | SIGNOR-94206 |
| ABL1 | phosphorylation up-regulates → | ESR1 PTyr52 | phosphorylation up-regulates → | ESR1 | 20101225 | SIGNOR-163566 |
| PRKDC | phosphorylation up-regulates → | ESR1 PSer118 | phosphorylation up-regulates → | ESR1 | 20219974 | SIGNOR-279561 |
| MAPK3 | phosphorylation up-regulates → | ESR1 PSer104 | phosphorylation up-regulates → | ESR1 | 17615152 | SIGNOR-156860 |
| MAPK1 | phosphorylation up-regulates → | ESR1 PSer104 | phosphorylation up-regulates → | ESR1 | 18372406 | SIGNOR-178133 |
| CSNK2A1 | phosphorylation up-regulates → | ESR1 PSer559 | phosphorylation down-regulates ⊣ | ESR1 | 20043841 | SIGNOR-162657 |
| GSK3B | phosphorylation up-regulates → | ESR1 PSer102 | phosphorylation up-regulates → | ESR1 | 16076840 | SIGNOR-139312 |
| MAPK3 | phosphorylation up-regulates → | ESR1 PSer106 | phosphorylation up-regulates → | ESR1 | 18372406 | SIGNOR-178145 |
| CDK2 | phosphorylation up-regulates → | ESR1 PSer104 | phosphorylation up-regulates → | ESR1 | 10428798 | SIGNOR-69710 |
| GSK3B | phosphorylation up-regulates → | ESR1 PSer106 | phosphorylation up-regulates → | ESR1 | 16076840 | SIGNOR-139320 |
| LCK | phosphorylation up-regulates → | ESR1 PTyr537 | phosphorylation up-regulates → | ESR1 | 9500442 | SIGNOR-55853 |
| IKBKE | phosphorylation up-regulates → | ESR1 PSer167 | phosphorylation up-regulates → | ESR1 | 19940156 | SIGNOR-161834 |
| CDK2 | phosphorylation up-regulates → | ESR1 PSer118 | phosphorylation up-regulates → | ESR1 | 10428798 | SIGNOR-69718 |
| GTF2H2 | phosphorylation up-regulates → | ESR1 PSer118 | phosphorylation up-regulates → | ESR1 | 10949034 | SIGNOR-260817 |
| AKT | phosphorylation up-regulates → | ESR1 PSer167 | phosphorylation up-regulates → | ESR1 | 11108261 | SIGNOR-244251 |
| RPS6KA1 | phosphorylation up-regulates → | ESR1 PSer167 | phosphorylation up-regulates → | ESR1 | 7838153 | SIGNOR-34113 |
| MAPK14 | phosphorylation up-regulates → | ESR1 PThr311 | phosphorylation up-regulates → | ESR1 | 12138194 | SIGNOR-90823 |
| CSNK2A1 | phosphorylation up-regulates → | ESR1 PSer282 | phosphorylation down-regulates ⊣ | ESR1 | 20043841 | SIGNOR-162653 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | ESR1 PSer104 | phosphorylation up-regulates → | ESR1 | 10428798 | SIGNOR-217284 |
| RPS6KB1 | phosphorylation up-regulates → | ESR1 PSer167 | phosphorylation up-regulates → | ESR1 | 7838153 | SIGNOR-34117 |
| ABL1 | phosphorylation up-regulates → | ESR1 PTyr219 | phosphorylation up-regulates → | ESR1 | 20101225 | SIGNOR-163562 |
| TFIIH | phosphorylation up-regulates → | ESR1 PSer118 | phosphorylation up-regulates → | ESR1 | 10949034 | SIGNOR-269356 |
| MAPK3 | phosphorylation up-regulates → | ESR1 PSer104 | phosphorylation up-regulates → | ESR1 | 18372406 | SIGNOR-178141 |
| AKT1 | phosphorylation up-regulates → | ESR1 PSer104 | phosphorylation up-regulates → | ESR1 | 11108261 | SIGNOR-84963 |
| CDK2 | phosphorylation up-regulates → | ESR1 PSer294 | phosphorylation up-regulates → | ESR1 | 23390529 | SIGNOR-200867 |
| MAPK3 | phosphorylation up-regulates → | ESR1 PSer118 | phosphorylation up-regulates → | ESR1 | 17615152 | SIGNOR-156868 |
| CDK7 | phosphorylation up-regulates → | ESR1 PSer118 | phosphorylation up-regulates → | ESR1 | 10949034 | SIGNOR-81170 |
| CDK3 | phosphorylation up-regulates → | ESR1 PSer118 | phosphorylation up-regulates → | ESR1 | 26202215 | SIGNOR-273187 |
| AKT2 | phosphorylation up-regulates → | ESR1 PSer167 | phosphorylation up-regulates → | ESR1 | 11139588 | SIGNOR-251490 |
| CHUK | phosphorylation up-regulates → | ESR1 PSer118 | phosphorylation up-regulates → | ESR1 | 15808510 | SIGNOR-279696 |
| MAPK1 | phosphorylation up-regulates → | ESR1 PSer118 | phosphorylation up-regulates → | ESR1 | 17615152 | SIGNOR-156856 |
| PRKACA | phosphorylation up-regulates → | ESR1 PSer236 | phosphorylation down-regulates ⊣ | ESR1 | 9891036 | SIGNOR-63984 |
| RPS6KA3 | phosphorylation up-regulates → | ESR1 PSer167 | phosphorylation up-regulates → | ESR1 | 19112174 | SIGNOR-182958 |
| CDK3 | phosphorylation up-regulates → | ESR1 PSer104 | phosphorylation up-regulates → | ESR1 | 26202215 | SIGNOR-273189 |
| ERK1/2 | phosphorylation up-regulates → | ESR1 PSer104 | phosphorylation up-regulates → | ESR1 | 17615152 | SIGNOR-244647 |
| AKT1 | phosphorylation up-regulates → | ESR1 PSer167 | phosphorylation up-regulates → | ESR1 | 11108261 | SIGNOR-84975 |
| CDK3 | phosphorylation up-regulates → | ESR1 PSer106 | phosphorylation up-regulates → | ESR1 | 26202215 | SIGNOR-273188 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| RPS6K | phosphorylation → up-regulates | ESR1 | SIGNOR-252807 |
| MAPK1 | phosphorylation → up-regulates | ESR1 | SIGNOR-156852 |
| MAPK3 | phosphorylation → up-regulates | ESR1 | SIGNOR-156864 |
| AKT | phosphorylation → up-regulates | ESR1 | SIGNOR-244255 |
| AKT | phosphorylation → up-regulates | ESR1 | SIGNOR-244247 |
| MNAT1 | phosphorylation → up-regulates activity | ESR1 | SIGNOR-260837 |
| MAPK1 | phosphorylation → up-regulates | ESR1 | SIGNOR-178137 |
| CyclinA2/CDK2 | phosphorylation → up-regulates | ESR1 | SIGNOR-217288 |
| ERK1/2 | phosphorylation → up-regulates | ESR1 | SIGNOR-244655 |
| SRC | phosphorylation → up-regulates | ESR1 | SIGNOR-55857 |
| MAPK1 | phosphorylation → up-regulates | ESR1 | SIGNOR-156848 |
| AKT | phosphorylation → up-regulates | ESR1 | SIGNOR-244243 |
| MAPK14 | phosphorylation → up-regulates | ESR1 | SIGNOR-136950 |
| PRKACA | phosphorylation → up-regulates | ESR1 | SIGNOR-125779 |
| AURKA | phosphorylation → up-regulates activity | ESR1 | SIGNOR-278507 |
| AURKA | phosphorylation → up-regulates activity | ESR1 | SIGNOR-278508 |
| PAK4 | phosphorylation → up-regulates activity | ESR1 | SIGNOR-279472 |
| CyclinA2/CDK2 | phosphorylation → up-regulates | ESR1 | SIGNOR-217292 |
| CDK2 | phosphorylation → up-regulates | ESR1 | SIGNOR-69714 |
| PTPN3 | dephosphorylation → up-regulates activity | ESR1 | SIGNOR-277127 |
| AKT1 | phosphorylation → up-regulates | ESR1 | SIGNOR-84971 |
| AKT1 | phosphorylation → up-regulates | ESR1 | SIGNOR-84967 |
| ERK1/2 | phosphorylation → up-regulates | ESR1 | SIGNOR-244651 |
| GSK3B | phosphorylation → up-regulates | ESR1 | SIGNOR-139316 |
| MAPK1 | phosphorylation → up-regulates | ESR1 | SIGNOR-96072 |
| GSK3B | phosphorylation → up-regulates | ESR1 | SIGNOR-139324 |
| DUSP22 | dephosphorylation → down-regulates activity | ESR1 | SIGNOR-248827 |
| LCK | phosphorylation → up-regulates | ESR1 | SIGNOR-72373 |
| PAK1 | phosphorylation → up-regulates | ESR1 | SIGNOR-94206 |
| Gbeta | phosphorylation → up-regulates | ESR1 | SIGNOR-270023 |
| ERBB2 | phosphorylation → up-regulates | ESR1 | SIGNOR-124962 |
| ABL1 | phosphorylation → up-regulates | ESR1 | SIGNOR-163566 |
| PRKDC | phosphorylation → up-regulates quantity by stabilization | ESR1 | SIGNOR-279561 |
| MTOR | phosphorylation → up-regulates activity | ESR1 | SIGNOR-278295 |
| MAPK3 | phosphorylation → up-regulates | ESR1 | SIGNOR-156860 |
| MAPK1 | phosphorylation → up-regulates | ESR1 | SIGNOR-178133 |
| CSNK2A1 | phosphorylation down-regulates | ESR1 | SIGNOR-162657 |
| GSK3B | phosphorylation → up-regulates | ESR1 | SIGNOR-139312 |
| MAPK3 | phosphorylation → up-regulates | ESR1 | SIGNOR-178145 |
| CDK2 | phosphorylation → up-regulates | ESR1 | SIGNOR-69710 |
| GSK3B | phosphorylation → up-regulates | ESR1 | SIGNOR-139320 |
| LCK | phosphorylation → up-regulates | ESR1 | SIGNOR-55853 |
| IKBKE | phosphorylation → up-regulates | ESR1 | SIGNOR-161834 |
| CDK2 | phosphorylation → up-regulates | ESR1 | SIGNOR-69718 |
| GTF2H2 | phosphorylation → up-regulates activity | ESR1 | SIGNOR-260817 |
| AKT | phosphorylation → up-regulates | ESR1 | SIGNOR-244251 |
| RPS6KA1 | phosphorylation → up-regulates | ESR1 | SIGNOR-34113 |
| MAPK14 | phosphorylation → up-regulates | ESR1 | SIGNOR-90823 |
| JAK2 | phosphorylation → down-regulates quantity | ESR1 | SIGNOR-278949 |
| CSNK2A1 | phosphorylation down-regulates | ESR1 | SIGNOR-162653 |
| CyclinA2/CDK2 | phosphorylation → up-regulates | ESR1 | SIGNOR-217284 |
| RPS6KB1 | phosphorylation → up-regulates | ESR1 | SIGNOR-34117 |
| ABL1 | phosphorylation → up-regulates | ESR1 | SIGNOR-163562 |
| TFIIH | phosphorylation → up-regulates | ESR1 | SIGNOR-269356 |
| MAPK3 | phosphorylation → up-regulates | ESR1 | SIGNOR-178141 |
| AKT1 | phosphorylation → up-regulates | ESR1 | SIGNOR-84963 |
| CDK2 | phosphorylation → up-regulates | ESR1 | SIGNOR-200867 |
| MAPK3 | phosphorylation → up-regulates | ESR1 | SIGNOR-156868 |
| CDK7 | phosphorylation → up-regulates | ESR1 | SIGNOR-81170 |
| CDK3 | phosphorylation → up-regulates activity | ESR1 | SIGNOR-273187 |
| AKT2 | phosphorylation → up-regulates activity | ESR1 | SIGNOR-251490 |
| CHUK | phosphorylation → up-regulates activity | ESR1 | SIGNOR-279696 |
| MAPK1 | phosphorylation → up-regulates | ESR1 | SIGNOR-156856 |
| PRKACA | phosphorylation down-regulates | ESR1 | SIGNOR-63984 |
| RPS6KA3 | phosphorylation → up-regulates | ESR1 | SIGNOR-182958 |
| EGFR | phosphorylation → up-regulates | ESR1 | SIGNOR-115734 |
| CDK3 | phosphorylation → up-regulates activity | ESR1 | SIGNOR-273189 |
| ERK1/2 | phosphorylation → up-regulates | ESR1 | SIGNOR-244647 |
| AKT1 | phosphorylation → up-regulates | ESR1 | SIGNOR-84975 |
| CDK3 | phosphorylation → up-regulates activity | ESR1 | SIGNOR-273188 |