| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK2 | ESR1 | Ser118 | LHPPPQLsPFLQPHG | phosphorylation up-regulates | 10428798 | SIGNOR-69718 |
| GTF2H2 | ESR1 | Ser118 | LHPPPQLsPFLQPHG | phosphorylation up-regulates activity | 10949034 | SIGNOR-260817 |
| MAPK1 | ESR1 | Ser118 | LHPPPQLsPFLQPHG | phosphorylation up-regulates | 17615152 | SIGNOR-156856 |
| TFIIH | ESR1 | Ser118 | LHPPPQLsPFLQPHG | phosphorylation up-regulates | 10949034 | SIGNOR-269356 |
| MAPK3 | ESR1 | Ser118 | LHPPPQLsPFLQPHG | phosphorylation up-regulates | 17615152 | SIGNOR-156868 |
| CDK7 | ESR1 | Ser118 | LHPPPQLsPFLQPHG | phosphorylation up-regulates | 10949034 | SIGNOR-81170 |
| CDK3 | ESR1 | Ser118 | LHPPPQLsPFLQPHG | phosphorylation up-regulates activity | 26202215 | SIGNOR-273187 |
| AKT | ESR1 | Ser118 | LHPPPQLsPFLQPHG | phosphorylation up-regulates | 11108261 | SIGNOR-244255 |
| MNAT1 | ESR1 | Ser118 | LHPPPQLsPFLQPHG | phosphorylation up-regulates activity | 10949034 | SIGNOR-260837 |
| ERK1/2 | ESR1 | Ser118 | LHPPPQLsPFLQPHG | phosphorylation up-regulates | 17615152 | SIGNOR-244655 |
| MAPK14 | ESR1 | Ser118 | LHPPPQLsPFLQPHG | phosphorylation up-regulates | 15879307 | SIGNOR-136950 |
| AKT1 | ESR1 | Ser118 | LHPPPQLsPFLQPHG | phosphorylation up-regulates | 11108261 | SIGNOR-84971 |
| MAPK1 | ESR1 | Ser118 | LHPPPQLsPFLQPHG | phosphorylation up-regulates | 12466266 | SIGNOR-96072 |
| GSK3B | ESR1 | Ser118 | LHPPPQLsPFLQPHG | phosphorylation up-regulates | 16076840 | SIGNOR-139324 |
| CyclinA2/CDK2 | ESR1 | Ser118 | LHPPPQLsPFLQPHG | phosphorylation up-regulates | 10428798 | SIGNOR-217292 |
| DUSP22 | ESR1 | Ser118 | LHPPPQLsPFLQPHG | dephosphorylation down-regulates activity | 17384676 | SIGNOR-248827 |
| CHUK | ESR1 | Ser118 | LHPPPQLsPFLQPHG | phosphorylation up-regulates activity | 15808510 | SIGNOR-279696 |
| PRKDC | ESR1 | Ser118 | LHPPPQLsPFLQPHG | phosphorylation up-regulates quantity by stabilization | 20219974 | SIGNOR-279561 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK2 | phosphorylation up-regulates → | ESR1 PSer118 | phosphorylation up-regulates → | ESR1 | 10428798 | SIGNOR-69718 |
| GTF2H2 | phosphorylation up-regulates → | ESR1 PSer118 | phosphorylation up-regulates → | ESR1 | 10949034 | SIGNOR-260817 |
| MAPK1 | phosphorylation up-regulates → | ESR1 PSer118 | phosphorylation up-regulates → | ESR1 | 17615152 | SIGNOR-156856 |
| TFIIH | phosphorylation up-regulates → | ESR1 PSer118 | phosphorylation up-regulates → | ESR1 | 10949034 | SIGNOR-269356 |
| MAPK3 | phosphorylation up-regulates → | ESR1 PSer118 | phosphorylation up-regulates → | ESR1 | 17615152 | SIGNOR-156868 |
| CDK7 | phosphorylation up-regulates → | ESR1 PSer118 | phosphorylation up-regulates → | ESR1 | 10949034 | SIGNOR-81170 |
| CDK3 | phosphorylation up-regulates → | ESR1 PSer118 | phosphorylation up-regulates → | ESR1 | 26202215 | SIGNOR-273187 |
| AKT | phosphorylation up-regulates → | ESR1 PSer118 | phosphorylation up-regulates → | ESR1 | 11108261 | SIGNOR-244255 |
| MNAT1 | phosphorylation up-regulates → | ESR1 PSer118 | phosphorylation up-regulates → | ESR1 | 10949034 | SIGNOR-260837 |
| ERK1/2 | phosphorylation up-regulates → | ESR1 PSer118 | phosphorylation up-regulates → | ESR1 | 17615152 | SIGNOR-244655 |
| MAPK14 | phosphorylation up-regulates → | ESR1 PSer118 | phosphorylation up-regulates → | ESR1 | 15879307 | SIGNOR-136950 |
| AKT1 | phosphorylation up-regulates → | ESR1 PSer118 | phosphorylation up-regulates → | ESR1 | 11108261 | SIGNOR-84971 |
| MAPK1 | phosphorylation up-regulates → | ESR1 PSer118 | phosphorylation up-regulates → | ESR1 | 12466266 | SIGNOR-96072 |
| GSK3B | phosphorylation up-regulates → | ESR1 PSer118 | phosphorylation up-regulates → | ESR1 | 16076840 | SIGNOR-139324 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | ESR1 PSer118 | phosphorylation up-regulates → | ESR1 | 10428798 | SIGNOR-217292 |
| DUSP22 | dephosphorylation down-regulates ⊣ | ESR1 PSer118 | dephosphorylation up-regulates → | ESR1 | 17384676 | SIGNOR-248827 |
| CHUK | phosphorylation up-regulates → | ESR1 PSer118 | phosphorylation up-regulates → | ESR1 | 15808510 | SIGNOR-279696 |
| PRKDC | phosphorylation up-regulates → | ESR1 PSer118 | phosphorylation up-regulates → | ESR1 | 20219974 | SIGNOR-279561 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK2 | phosphorylation → up-regulates | ESR1 | SIGNOR-69718 |
| GTF2H2 | phosphorylation → up-regulates activity | ESR1 | SIGNOR-260817 |
| MAPK1 | phosphorylation → up-regulates | ESR1 | SIGNOR-156856 |
| TFIIH | phosphorylation → up-regulates | ESR1 | SIGNOR-269356 |
| MAPK3 | phosphorylation → up-regulates | ESR1 | SIGNOR-156868 |
| CDK7 | phosphorylation → up-regulates | ESR1 | SIGNOR-81170 |
| CDK3 | phosphorylation → up-regulates activity | ESR1 | SIGNOR-273187 |
| AKT | phosphorylation → up-regulates | ESR1 | SIGNOR-244255 |
| MNAT1 | phosphorylation → up-regulates activity | ESR1 | SIGNOR-260837 |
| ERK1/2 | phosphorylation → up-regulates | ESR1 | SIGNOR-244655 |
| MAPK14 | phosphorylation → up-regulates | ESR1 | SIGNOR-136950 |
| AKT1 | phosphorylation → up-regulates | ESR1 | SIGNOR-84971 |
| MAPK1 | phosphorylation → up-regulates | ESR1 | SIGNOR-96072 |
| GSK3B | phosphorylation → up-regulates | ESR1 | SIGNOR-139324 |
| CyclinA2/CDK2 | phosphorylation → up-regulates | ESR1 | SIGNOR-217292 |
| DUSP22 | dephosphorylation → down-regulates activity | ESR1 | SIGNOR-248827 |
| CHUK | phosphorylation → up-regulates activity | ESR1 | SIGNOR-279696 |
| PRKDC | phosphorylation → up-regulates quantity by stabilization | ESR1 | SIGNOR-279561 |
