| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinA2/CDK2 | ESR1 | Ser104 | FPPLNSVsPSPLMLL | phosphorylation up-regulates | 10428798 | SIGNOR-217284 |
| GSK3B | ESR1 | Ser104 | FPPLNSVsPSPLMLL | phosphorylation up-regulates | 16076840 | SIGNOR-139316 |
| MAPK3 | ESR1 | Ser104 | FPPLNSVsPSPLMLL | phosphorylation up-regulates | 18372406 | SIGNOR-178141 |
| MAPK3 | ESR1 | Ser104 | FPPLNSVsPSPLMLL | phosphorylation up-regulates | 17615152 | SIGNOR-156860 |
| CDK2 | ESR1 | Ser104 | FPPLNSVsPSPLMLL | phosphorylation up-regulates | 10428798 | SIGNOR-69710 |
| MAPK1 | ESR1 | Ser104 | FPPLNSVsPSPLMLL | phosphorylation up-regulates | 18372406 | SIGNOR-178133 |
| CDK3 | ESR1 | Ser104 | FPPLNSVsPSPLMLL | phosphorylation up-regulates activity | 26202215 | SIGNOR-273189 |
| AKT1 | ESR1 | Ser104 | FPPLNSVsPSPLMLL | phosphorylation up-regulates | 11108261 | SIGNOR-84963 |
| AKT | ESR1 | Ser104 | FPPLNSVsPSPLMLL | phosphorylation up-regulates | 11108261 | SIGNOR-244243 |
| MAPK1 | ESR1 | Ser104 | FPPLNSVsPSPLMLL | phosphorylation up-regulates | 17615152 | SIGNOR-156848 |
| ERK1/2 | ESR1 | Ser104 | FPPLNSVsPSPLMLL | phosphorylation up-regulates | 17615152 | SIGNOR-244647 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinA2/CDK2 | phosphorylation up-regulates → | ESR1 PSer104 | phosphorylation up-regulates → | ESR1 | 10428798 | SIGNOR-217284 |
| GSK3B | phosphorylation up-regulates → | ESR1 PSer104 | phosphorylation up-regulates → | ESR1 | 16076840 | SIGNOR-139316 |
| MAPK3 | phosphorylation up-regulates → | ESR1 PSer104 | phosphorylation up-regulates → | ESR1 | 18372406 | SIGNOR-178141 |
| MAPK3 | phosphorylation up-regulates → | ESR1 PSer104 | phosphorylation up-regulates → | ESR1 | 17615152 | SIGNOR-156860 |
| CDK2 | phosphorylation up-regulates → | ESR1 PSer104 | phosphorylation up-regulates → | ESR1 | 10428798 | SIGNOR-69710 |
| MAPK1 | phosphorylation up-regulates → | ESR1 PSer104 | phosphorylation up-regulates → | ESR1 | 18372406 | SIGNOR-178133 |
| CDK3 | phosphorylation up-regulates → | ESR1 PSer104 | phosphorylation up-regulates → | ESR1 | 26202215 | SIGNOR-273189 |
| AKT1 | phosphorylation up-regulates → | ESR1 PSer104 | phosphorylation up-regulates → | ESR1 | 11108261 | SIGNOR-84963 |
| AKT | phosphorylation up-regulates → | ESR1 PSer104 | phosphorylation up-regulates → | ESR1 | 11108261 | SIGNOR-244243 |
| MAPK1 | phosphorylation up-regulates → | ESR1 PSer104 | phosphorylation up-regulates → | ESR1 | 17615152 | SIGNOR-156848 |
| ERK1/2 | phosphorylation up-regulates → | ESR1 PSer104 | phosphorylation up-regulates → | ESR1 | 17615152 | SIGNOR-244647 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CyclinA2/CDK2 | phosphorylation → up-regulates | ESR1 | SIGNOR-217284 |
| GSK3B | phosphorylation → up-regulates | ESR1 | SIGNOR-139316 |
| MAPK3 | phosphorylation → up-regulates | ESR1 | SIGNOR-178141 |
| MAPK3 | phosphorylation → up-regulates | ESR1 | SIGNOR-156860 |
| CDK2 | phosphorylation → up-regulates | ESR1 | SIGNOR-69710 |
| MAPK1 | phosphorylation → up-regulates | ESR1 | SIGNOR-178133 |
| CDK3 | phosphorylation → up-regulates activity | ESR1 | SIGNOR-273189 |
| AKT1 | phosphorylation → up-regulates | ESR1 | SIGNOR-84963 |
| AKT | phosphorylation → up-regulates | ESR1 | SIGNOR-244243 |
| MAPK1 | phosphorylation → up-regulates | ESR1 | SIGNOR-156848 |
| ERK1/2 | phosphorylation → up-regulates | ESR1 | SIGNOR-244647 |
