| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | ESR1 | Ser305 | IKRSKKNsLALSLTA | phosphorylation up-regulates | 15193262 | SIGNOR-125779 |
| AURKA | ESR1 | Ser305 | IKRSKKNsLALSLTA | phosphorylation up-regulates activity | 24166501 | SIGNOR-278507 |
| PAK4 | ESR1 | Ser305 | IKRSKKNsLALSLTA | phosphorylation up-regulates activity | 26554417 | SIGNOR-279472 |
| PAK1 | ESR1 | Ser305 | IKRSKKNsLALSLTA | phosphorylation up-regulates | 12374744 | SIGNOR-94206 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | phosphorylation up-regulates → | ESR1 PSer305 | phosphorylation up-regulates → | ESR1 | 15193262 | SIGNOR-125779 |
| AURKA | phosphorylation up-regulates → | ESR1 PSer305 | phosphorylation up-regulates → | ESR1 | 24166501 | SIGNOR-278507 |
| PAK4 | phosphorylation up-regulates → | ESR1 PSer305 | phosphorylation up-regulates → | ESR1 | 26554417 | SIGNOR-279472 |
| PAK1 | phosphorylation up-regulates → | ESR1 PSer305 | phosphorylation up-regulates → | ESR1 | 12374744 | SIGNOR-94206 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKACA | phosphorylation → up-regulates | ESR1 | SIGNOR-125779 |
| AURKA | phosphorylation → up-regulates activity | ESR1 | SIGNOR-278507 |
| PAK4 | phosphorylation → up-regulates activity | ESR1 | SIGNOR-279472 |
| PAK1 | phosphorylation → up-regulates | ESR1 | SIGNOR-94206 |
