| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT1 | ESR1 | Ser167 | GGRERLAsTNDKGSM | phosphorylation up-regulates | 11108261 | SIGNOR-84975 |
| AURKA | ESR1 | Ser167 | GGRERLAsTNDKGSM | phosphorylation up-regulates activity | 24166501 | SIGNOR-278508 |
| RPS6K | ESR1 | Ser167 | GGRERLAsTNDKGSM | phosphorylation up-regulates | 7838153 | SIGNOR-252807 |
| IKBKE | ESR1 | Ser167 | GGRERLAsTNDKGSM | phosphorylation up-regulates | 19940156 | SIGNOR-161834 |
| RPS6KA3 | ESR1 | Ser167 | GGRERLAsTNDKGSM | phosphorylation up-regulates | 19112174 | SIGNOR-182958 |
| RPS6KA1 | ESR1 | Ser167 | GGRERLAsTNDKGSM | phosphorylation up-regulates | 7838153 | SIGNOR-34113 |
| RPS6KB1 | ESR1 | Ser167 | GGRERLAsTNDKGSM | phosphorylation up-regulates | 7838153 | SIGNOR-34117 |
| AKT | ESR1 | Ser167 | GGRERLAsTNDKGSM | phosphorylation up-regulates | 11108261 | SIGNOR-244251 |
| AKT2 | ESR1 | Ser167 | GGRERLAsTNDKGSM | phosphorylation up-regulates activity | 11139588 | SIGNOR-251490 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT1 | phosphorylation up-regulates → | ESR1 PSer167 | phosphorylation up-regulates → | ESR1 | 11108261 | SIGNOR-84975 |
| AURKA | phosphorylation up-regulates → | ESR1 PSer167 | phosphorylation up-regulates → | ESR1 | 24166501 | SIGNOR-278508 |
| RPS6K | phosphorylation up-regulates → | ESR1 PSer167 | phosphorylation up-regulates → | ESR1 | 7838153 | SIGNOR-252807 |
| IKBKE | phosphorylation up-regulates → | ESR1 PSer167 | phosphorylation up-regulates → | ESR1 | 19940156 | SIGNOR-161834 |
| RPS6KA3 | phosphorylation up-regulates → | ESR1 PSer167 | phosphorylation up-regulates → | ESR1 | 19112174 | SIGNOR-182958 |
| RPS6KA1 | phosphorylation up-regulates → | ESR1 PSer167 | phosphorylation up-regulates → | ESR1 | 7838153 | SIGNOR-34113 |
| RPS6KB1 | phosphorylation up-regulates → | ESR1 PSer167 | phosphorylation up-regulates → | ESR1 | 7838153 | SIGNOR-34117 |
| AKT | phosphorylation up-regulates → | ESR1 PSer167 | phosphorylation up-regulates → | ESR1 | 11108261 | SIGNOR-244251 |
| AKT2 | phosphorylation up-regulates → | ESR1 PSer167 | phosphorylation up-regulates → | ESR1 | 11139588 | SIGNOR-251490 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT1 | phosphorylation → up-regulates | ESR1 | SIGNOR-84975 |
| AURKA | phosphorylation → up-regulates activity | ESR1 | SIGNOR-278508 |
| RPS6K | phosphorylation → up-regulates | ESR1 | SIGNOR-252807 |
| IKBKE | phosphorylation → up-regulates | ESR1 | SIGNOR-161834 |
| RPS6KA3 | phosphorylation → up-regulates | ESR1 | SIGNOR-182958 |
| RPS6KA1 | phosphorylation → up-regulates | ESR1 | SIGNOR-34113 |
| RPS6KB1 | phosphorylation → up-regulates | ESR1 | SIGNOR-34117 |
| AKT | phosphorylation → up-regulates | ESR1 | SIGNOR-244251 |
| AKT2 | phosphorylation → up-regulates activity | ESR1 | SIGNOR-251490 |
