| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SRC | ESR1 | Tyr537 | CKNVVPLyDLLLEML | phosphorylation up-regulates | 9500442 | SIGNOR-55857 |
| PTPN3 | ESR1 | Tyr537 | CKNVVPLyDLLLEML | dephosphorylation up-regulates activity | 26079946 | SIGNOR-277127 |
| LCK | ESR1 | Tyr537 | CKNVVPLyDLLLEML | phosphorylation up-regulates | 10571988 | SIGNOR-72373 |
| LCK | ESR1 | Tyr537 | CKNVVPLyDLLLEML | phosphorylation up-regulates | 9500442 | SIGNOR-55853 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SRC | phosphorylation up-regulates → | ESR1 PTyr537 | phosphorylation up-regulates → | ESR1 | 9500442 | SIGNOR-55857 |
| PTPN3 | dephosphorylation down-regulates ⊣ | ESR1 PTyr537 | dephosphorylation down-regulates ⊣ | ESR1 | 26079946 | SIGNOR-277127 |
| LCK | phosphorylation up-regulates → | ESR1 PTyr537 | phosphorylation up-regulates → | ESR1 | 10571988 | SIGNOR-72373 |
| LCK | phosphorylation up-regulates → | ESR1 PTyr537 | phosphorylation up-regulates → | ESR1 | 9500442 | SIGNOR-55853 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| SRC | phosphorylation → up-regulates | ESR1 | SIGNOR-55857 |
| PTPN3 | dephosphorylation → up-regulates activity | ESR1 | SIGNOR-277127 |
| LCK | phosphorylation → up-regulates | ESR1 | SIGNOR-72373 |
| LCK | phosphorylation → up-regulates | ESR1 | SIGNOR-55853 |
