| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SRC | ANXA1 | Thr216 | AGERRKGtDVNVFNT | phosphorylation unknown | 24103589 | SIGNOR-202800 |
| EGFR | ANXA1 | Tyr21 | IENEEQEyVQTVKSS | phosphorylation up-regulates | 24103589 | SIGNOR-202776 |
| TRPM7 | ANXA1 | Ser5 | sEFLKQAW | phosphorylation up-regulates | 24103589 | SIGNOR-202804 |
| PRKCA | ANXA1 | Ser27 | EYVQTVKsSKGGPGS | phosphorylation up-regulates | 24103589 | SIGNOR-202780 |
| PRKCH | ANXA1 | Ser27 | EYVQTVKsSKGGPGS | phosphorylation up-regulates | 24103589 | SIGNOR-202792 |
| PRKCB | ANXA1 | Ser27 | EYVQTVKsSKGGPGS | phosphorylation up-regulates | 24103589 | SIGNOR-202784 |
| PRKCG | ANXA1 | Ser27 | EYVQTVKsSKGGPGS | phosphorylation up-regulates | 24103589 | SIGNOR-202788 |
| SRC | ANXA1 | Tyr21 | IENEEQEyVQTVKSS | phosphorylation up-regulates | 24103589 | SIGNOR-202796 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SRC | phosphorylation up-regulates → | ANXA1 PThr216 | phosphorylation down-regulates ⊣ | ANXA1 | 24103589 | SIGNOR-202800 |
| EGFR | phosphorylation up-regulates → | ANXA1 PTyr21 | phosphorylation up-regulates → | ANXA1 | 24103589 | SIGNOR-202776 |
| TRPM7 | phosphorylation up-regulates → | ANXA1 PSer5 | phosphorylation up-regulates → | ANXA1 | 24103589 | SIGNOR-202804 |
| PRKCA | phosphorylation up-regulates → | ANXA1 PSer27 | phosphorylation up-regulates → | ANXA1 | 24103589 | SIGNOR-202780 |
| PRKCH | phosphorylation up-regulates → | ANXA1 PSer27 | phosphorylation up-regulates → | ANXA1 | 24103589 | SIGNOR-202792 |
| PRKCB | phosphorylation up-regulates → | ANXA1 PSer27 | phosphorylation up-regulates → | ANXA1 | 24103589 | SIGNOR-202784 |
| PRKCG | phosphorylation up-regulates → | ANXA1 PSer27 | phosphorylation up-regulates → | ANXA1 | 24103589 | SIGNOR-202788 |
| SRC | phosphorylation up-regulates → | ANXA1 PTyr21 | phosphorylation up-regulates → | ANXA1 | 24103589 | SIGNOR-202796 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| SRC | phosphorylation → unknown | ANXA1 | SIGNOR-202800 |
| EGFR | phosphorylation → up-regulates | ANXA1 | SIGNOR-202776 |
| TRPM7 | phosphorylation → up-regulates | ANXA1 | SIGNOR-202804 |
| PRKCA | phosphorylation → up-regulates | ANXA1 | SIGNOR-202780 |
| PRKCH | phosphorylation → up-regulates | ANXA1 | SIGNOR-202792 |
| PRKCB | phosphorylation → up-regulates | ANXA1 | SIGNOR-202784 |
| PRKCG | phosphorylation → up-regulates | ANXA1 | SIGNOR-202788 |
| SRC | phosphorylation → up-regulates | ANXA1 | SIGNOR-202796 |
