Entity Details

Name GAPDH
ID P04406
Role substrate
Enzymatic Domains
View in

Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
STK4GAPDH–phosphorylation
up-regulates activity		23527007SIGNOR-279295
AMPKGAPDHSer122GAKRVIIsAPSADAPphosphorylation
up-regulates activity		26626483SIGNOR-267578
PRKAA1GAPDHSer122GAKRVIIsAPSADAPphosphorylation
up-regulates activity		26626483SIGNOR-259857
VRK2GAPDHSer151
View in OncoXplorer
LKIISNAsCTTNCLAphosphorylation
up-regulates activity		37450367SIGNOR-277840
AKT1GAPDHThr237
View in OncoXplorer
GMAFRVPtANVSVVDphosphorylation
down-regulates activity		23332158SIGNOR-280174
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
AMPKphosphorylation
up-regulates
→
GAPDH
PSer122		phosphorylation
up-regulates
→		GAPDH26626483SIGNOR-267578
PRKAA1phosphorylation
up-regulates
→
GAPDH
PSer122		phosphorylation
up-regulates
→		GAPDH26626483SIGNOR-259857
VRK2phosphorylation
up-regulates
→
GAPDH
PSer151		phosphorylation
up-regulates
→		GAPDH37450367SIGNOR-277840
AKT1phosphorylation
up-regulates
→
GAPDH
PThr237		phosphorylation
down-regulates
⊣		GAPDH23332158SIGNOR-280174
Regulator Mechanism/Effect Target SIGNOR-ID
STK4phosphorylation
→
up-regulates activity 		GAPDHSIGNOR-279295
AMPKphosphorylation
→
up-regulates activity 		GAPDHSIGNOR-267578
PRKAA1phosphorylation
→
up-regulates activity 		GAPDHSIGNOR-259857
VRK2phosphorylation
→
up-regulates activity 		GAPDHSIGNOR-277840
AKT1phosphorylation
→
down-regulates activity 		GAPDHSIGNOR-280174