Entity Details

Name GAPDH
ID P04406
Role substrate
Enzymatic Domains
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
STK4GAPDH–phosphorylation
up-regulates activity		23527007SIGNOR-279295
AMPKGAPDHSer122GAKRVIIsAPSADAPphosphorylation
up-regulates activity		26626483SIGNOR-267578
AKT1GAPDHThr237
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GMAFRVPtANVSVVDphosphorylation
down-regulates activity		23332158SIGNOR-280174
PRKAA1GAPDHSer122GAKRVIIsAPSADAPphosphorylation
up-regulates activity		26626483SIGNOR-259857
VRK2GAPDHSer151
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LKIISNAsCTTNCLAphosphorylation
up-regulates activity		37450367SIGNOR-277840
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
AMPKphosphorylation
up-regulates
→
GAPDH
PSer122		phosphorylation
up-regulates
→		GAPDH26626483SIGNOR-267578
AKT1phosphorylation
up-regulates
→
GAPDH
PThr237		phosphorylation
down-regulates
⊣		GAPDH23332158SIGNOR-280174
PRKAA1phosphorylation
up-regulates
→
GAPDH
PSer122		phosphorylation
up-regulates
→		GAPDH26626483SIGNOR-259857
VRK2phosphorylation
up-regulates
→
GAPDH
PSer151		phosphorylation
up-regulates
→		GAPDH37450367SIGNOR-277840
Regulator Mechanism/Effect Target SIGNOR-ID
STK4phosphorylation
→
up-regulates activity 		GAPDHSIGNOR-279295
AMPKphosphorylation
→
up-regulates activity 		GAPDHSIGNOR-267578
AKT1phosphorylation
→
down-regulates activity 		GAPDHSIGNOR-280174
PRKAA1phosphorylation
→
up-regulates activity 		GAPDHSIGNOR-259857
VRK2phosphorylation
→
up-regulates activity 		GAPDHSIGNOR-277840