| Name | ERBB2 |
| ID | P04626 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 720-987 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ERBB2 | MBD4 | – | phosphorylation up-regulates activity | 22964581 | SIGNOR-279408 | |
| ERBB2 | ABL1 | – | phosphorylation up-regulates activity | 19275932 | SIGNOR-279407 | |
| ERBB2 | EGFR | Tyr1197 | STAENAEyLRVAPQS | phosphorylation up-regulates activity | 23027125 | SIGNOR-278474 |
| ERBB2 | ESR1 | – | phosphorylation up-regulates | 15173068 | SIGNOR-124962 | |
| ERBB2 | ERBB2 | Tyr1112 | DPSPLQRySEDPTVP | phosphorylation down-regulates | 1706616 | SIGNOR-21211 |
| ERBB2 | ERBB2 | Tyr1196 | GAVENPEyLTPQGGA | phosphorylation up-regulates | 15156151 | SIGNOR-124856 |
| ERBB2 | ERBB2 | Tyr1222 | PAFDNLYyWDQDPPE | phosphorylation up-regulates | 15156151 | SIGNOR-124860 |
| ERBB2 | ERBB2 | Tyr1221 | SPAFDNLyYWDQDPP | phosphorylation up-regulates | 1706616 | SIGNOR-21199 |
| ERBB2 | ERBB2 | Tyr1248 | PTAENPEyLGLDVPV | phosphorylation up-regulates | 1706616 | SIGNOR-21203 |
| ERBB2 | ERBB2 | Tyr1023 | DLVDAEEyLVPQQGF | phosphorylation up-regulates activity | 1706616 | SIGNOR-251129 |
| ERBB2 | ERBB2 | Tyr1139 | TCSPQPEyVNQPDVR | phosphorylation up-regulates activity | 1706616 | SIGNOR-251127 |
| ERBB2 | ERBB2 | Tyr1222 | PAFDNLYyWDQDPPE | phosphorylation up-regulates activity | 1706616 | SIGNOR-251130 |
| ERBB2 | ERBB2 | Tyr1248 | PTAENPEyLGLDVPV | phosphorylation up-regulates activity | 1706616 | SIGNOR-251128 |
| ERBB2 | CDK1 | Tyr15 | EKIGEGTyGVVYKGR | phosphorylation down-regulates | 12049736 | SIGNOR-88671 |
| ERBB2 | ERBB3 | – | phosphorylation up-regulates activity | 23912457 | SIGNOR-278200 | |
| ERBB2 | CTNNB1 | Tyr654 | RNEGVATyAAAVLFR | phosphorylation down-regulates activity | 23576562 | SIGNOR-279041 |
| ERBB2 | FASN | – | phosphorylation up-regulates activity | 27692180 | SIGNOR-278399 | |
| ERBB2 | PTK2 | Tyr397 | SVSETDDyAEIIDEE | phosphorylation up-regulates activity | 27638858 | SIGNOR-278475 |
| ERBB2 | SHCBP1 | Ser273 | SSLSNCNsDSEQENI | phosphorylation up-regulates activity | 35013128 | SIGNOR-280009 |
| ERBB2 | DOCK7 | Tyr1257 | METVPQLyDFTETHN | phosphorylation up-regulates | 18426980 | SIGNOR-178348 |
| ERBB2 | BBC3 | – | phosphorylation down-regulates activity | 24236056 | SIGNOR-278224 | |
| ERBB2 | BBC3 | Tyr152 | ADDLNAQyERRRQEE | phosphorylation down-regulates quantity by destabilization | 24236056 | SIGNOR-276472 |
| ERBB2 | BBC3 | Tyr172 | PSPWRVLyNLIMGLL | phosphorylation down-regulates quantity by destabilization | 24236056 | SIGNOR-276474 |
| ERBB2 | BBC3 | Tyr58 | PTLLPAAyLCAPTAP | phosphorylation down-regulates quantity by destabilization | 24236056 | SIGNOR-276473 |
| ERBB2 | ErbB receptor family | – | phosphorylation up-regulates activity | 1706616 | SIGNOR-269875 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ERBB2 | phosphorylation up-regulates → | EGFR PTyr1197 | phosphorylation up-regulates → | EGFR | 23027125 | SIGNOR-278474 |
| ERBB2 | phosphorylation up-regulates → | ERBB2 PTyr1112 | phosphorylation down-regulates ⊣ | ERBB2 | 1706616 | SIGNOR-21211 |
| ERBB2 | phosphorylation up-regulates → | ERBB2 PTyr1196 | phosphorylation up-regulates → | ERBB2 | 15156151 | SIGNOR-124856 |
| ERBB2 | phosphorylation up-regulates → | ERBB2 PTyr1222 | phosphorylation up-regulates → | ERBB2 | 15156151 | SIGNOR-124860 |
| ERBB2 | phosphorylation up-regulates → | ERBB2 PTyr1221 | phosphorylation up-regulates → | ERBB2 | 1706616 | SIGNOR-21199 |
| ERBB2 | phosphorylation up-regulates → | ERBB2 PTyr1248 | phosphorylation up-regulates → | ERBB2 | 1706616 | SIGNOR-21203 |
| ERBB2 | phosphorylation up-regulates → | ERBB2 PTyr1023 | phosphorylation up-regulates → | ERBB2 | 1706616 | SIGNOR-251129 |
| ERBB2 | phosphorylation up-regulates → | ERBB2 PTyr1139 | phosphorylation up-regulates → | ERBB2 | 1706616 | SIGNOR-251127 |
| ERBB2 | phosphorylation up-regulates → | ERBB2 PTyr1222 | phosphorylation up-regulates → | ERBB2 | 1706616 | SIGNOR-251130 |
| ERBB2 | phosphorylation up-regulates → | ERBB2 PTyr1248 | phosphorylation up-regulates → | ERBB2 | 1706616 | SIGNOR-251128 |
| ERBB2 | phosphorylation up-regulates → | CDK1 PTyr15 | phosphorylation down-regulates ⊣ | CDK1 | 12049736 | SIGNOR-88671 |
| ERBB2 | phosphorylation up-regulates → | CTNNB1 PTyr654 | phosphorylation down-regulates ⊣ | CTNNB1 | 23576562 | SIGNOR-279041 |
| ERBB2 | phosphorylation up-regulates → | PTK2 PTyr397 | phosphorylation up-regulates → | PTK2 | 27638858 | SIGNOR-278475 |
| ERBB2 | phosphorylation up-regulates → | SHCBP1 PSer273 | phosphorylation up-regulates → | SHCBP1 | 35013128 | SIGNOR-280009 |
| ERBB2 | phosphorylation up-regulates → | DOCK7 PTyr1257 | phosphorylation up-regulates → | DOCK7 | 18426980 | SIGNOR-178348 |
| ERBB2 | phosphorylation up-regulates → | BBC3 PTyr152 | phosphorylation down-regulates ⊣ | BBC3 | 24236056 | SIGNOR-276472 |
| ERBB2 | phosphorylation up-regulates → | BBC3 PTyr172 | phosphorylation down-regulates ⊣ | BBC3 | 24236056 | SIGNOR-276474 |
| ERBB2 | phosphorylation up-regulates → | BBC3 PTyr58 | phosphorylation down-regulates ⊣ | BBC3 | 24236056 | SIGNOR-276473 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ERBB2 | phosphorylation → up-regulates activity | MBD4 | SIGNOR-279408 |
| ERBB2 | phosphorylation → up-regulates activity | ABL1 | SIGNOR-279407 |
| ERBB2 | phosphorylation → up-regulates activity | EGFR | SIGNOR-278474 |
| ERBB2 | phosphorylation → up-regulates | ESR1 | SIGNOR-124962 |
| ERBB2 | phosphorylation down-regulates | ERBB2 | SIGNOR-21211 |
| ERBB2 | phosphorylation → up-regulates | ERBB2 | SIGNOR-124856 |
| ERBB2 | phosphorylation → up-regulates | ERBB2 | SIGNOR-124860 |
| ERBB2 | phosphorylation → up-regulates | ERBB2 | SIGNOR-21199 |
| ERBB2 | phosphorylation → up-regulates | ERBB2 | SIGNOR-21203 |
| ERBB2 | phosphorylation → up-regulates activity | ERBB2 | SIGNOR-251129 |
| ERBB2 | phosphorylation → up-regulates activity | ERBB2 | SIGNOR-251127 |
| ERBB2 | phosphorylation → up-regulates activity | ERBB2 | SIGNOR-251130 |
| ERBB2 | phosphorylation → up-regulates activity | ERBB2 | SIGNOR-251128 |
| ERBB2 | phosphorylation down-regulates | CDK1 | SIGNOR-88671 |
| ERBB2 | phosphorylation → up-regulates activity | ERBB3 | SIGNOR-278200 |
| ERBB2 | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-279041 |
| ERBB2 | phosphorylation → up-regulates activity | FASN | SIGNOR-278399 |
| ERBB2 | phosphorylation → up-regulates activity | PTK2 | SIGNOR-278475 |
| ERBB2 | phosphorylation → up-regulates activity | SHCBP1 | SIGNOR-280009 |
| ERBB2 | phosphorylation → up-regulates | DOCK7 | SIGNOR-178348 |
| ERBB2 | phosphorylation → down-regulates activity | BBC3 | SIGNOR-278224 |
| ERBB2 | phosphorylation down-regulates quantity by destabilization | BBC3 | SIGNOR-276472 |
| ERBB2 | phosphorylation down-regulates quantity by destabilization | BBC3 | SIGNOR-276474 |
| ERBB2 | phosphorylation down-regulates quantity by destabilization | BBC3 | SIGNOR-276473 |
| ERBB2 | phosphorylation → up-regulates activity | ErbB receptor family | SIGNOR-269875 |