Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
DUSP3	ERBB2	Tyr877	LDIDETEyHADGGKV	dephosphorylation down-regulates activity	21262974	SIGNOR-248533
DUSP3	ERBB2	Tyr1221	SPAFDNLyYWDQDPP	dephosphorylation down-regulates activity	21262974	SIGNOR-248534
PTPN12	ERBB2	Tyr1196	GAVENPEyLTPQGGA	dephosphorylation down-regulates activity	29330094	SIGNOR-277038
CDK5	ERBB2	–		phosphorylation up-regulates activity	26509276	SIGNOR-279155
PTPN18	ERBB2	Tyr1196	GAVENPEyLTPQGGA	dephosphorylation down-regulates quantity by destabilization	25081058	SIGNOR-262596
PTPN18	ERBB2	–		dephosphorylation down-regulates quantity by destabilization	25081058	SIGNOR-277031
PRKACA	ERBB2	Thr686	QQKIRKYtMRRLLQE	phosphorylation up-regulates	18799465	SIGNOR-181191
PTPN13	ERBB2	–		dephosphorylation down-regulates activity	19734941	SIGNOR-277087
ERBB2	ERBB2	Tyr1248 View in OncoXplorer	PTAENPEyLGLDVPV	phosphorylation up-regulates activity	1706616	SIGNOR-251128
SRC	ERBB2	–		phosphorylation up-regulates activity	26114632	SIGNOR-279432
ERBB2	ERBB2	Tyr1221	SPAFDNLyYWDQDPP	phosphorylation up-regulates	1706616	SIGNOR-21199
ERBB2	ERBB2	Tyr1222	PAFDNLYyWDQDPPE	phosphorylation up-regulates	15156151	SIGNOR-124860
ERBB2	ERBB2	Tyr1023	DLVDAEEyLVPQQGF	phosphorylation up-regulates activity	1706616	SIGNOR-251129
ERBB2	ERBB2	Tyr1248 View in OncoXplorer	PTAENPEyLGLDVPV	phosphorylation up-regulates	1706616	SIGNOR-21203
PTPN18	ERBB2	Tyr1112	DPSPLQRySEDPTVP	dephosphorylation down-regulates quantity by destabilization	25081058	SIGNOR-262595
ERBB2	ERBB2	Tyr1222	PAFDNLYyWDQDPPE	phosphorylation up-regulates activity	1706616	SIGNOR-251130
PTPRO	ERBB2	Tyr1248 View in OncoXplorer	PTAENPEyLGLDVPV	dephosphorylation down-regulates quantity by destabilization	27345410	SIGNOR-276979
AREG	ERBB2	–		phosphorylation up-regulates	7679104	SIGNOR-31199
ERBB2	ERBB2	Tyr1139 View in OncoXplorer	TCSPQPEyVNQPDVR	phosphorylation up-regulates activity	1706616	SIGNOR-251127
JAK2	ERBB2	–		phosphorylation up-regulates activity	10938266	SIGNOR-279197
ERBB2	ERBB2	Tyr1112	DPSPLQRySEDPTVP	phosphorylation down-regulates	1706616	SIGNOR-21211
PTPN11	ERBB2	Tyr1023	DLVDAEEyLVPQQGF	dephosphorylation down-regulates	32024694	SIGNOR-262957
EGFR	ERBB2	Tyr1248 View in OncoXplorer	PTAENPEyLGLDVPV	phosphorylation up-regulates activity	12354693	SIGNOR-251094
PTPRG	ERBB2	Tyr1248 View in OncoXplorer	PTAENPEyLGLDVPV	dephosphorylation up-regulates activity	25624455	SIGNOR-254701
PTPN18	ERBB2	Tyr1248 View in OncoXplorer	PTAENPEyLGLDVPV	dephosphorylation down-regulates quantity by destabilization	25081058	SIGNOR-262597
ERBB2	ERBB2	Tyr1196	GAVENPEyLTPQGGA	phosphorylation up-regulates	15156151	SIGNOR-124856
PTPN9	ERBB2	–		dephosphorylation down-regulates activity	20335174	SIGNOR-277170
AXL	ERBB2	–		phosphorylation down-regulates activity	20818175	SIGNOR-280193

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
DUSP3	dephosphorylation down-regulates ⊣	ERBB2 PTyr877	dephosphorylation up-regulates →	ERBB2	21262974	SIGNOR-248533
DUSP3	dephosphorylation down-regulates ⊣	ERBB2 PTyr1221	dephosphorylation up-regulates →	ERBB2	21262974	SIGNOR-248534
PTPN12	dephosphorylation down-regulates ⊣	ERBB2 PTyr1196	dephosphorylation up-regulates →	ERBB2	29330094	SIGNOR-277038
PTPN18	dephosphorylation down-regulates ⊣	ERBB2 PTyr1196	dephosphorylation up-regulates →	ERBB2	25081058	SIGNOR-262596
PRKACA	phosphorylation up-regulates →	ERBB2 PThr686	phosphorylation up-regulates →	ERBB2	18799465	SIGNOR-181191
ERBB2	phosphorylation up-regulates →	ERBB2 PTyr1248	phosphorylation up-regulates →	ERBB2	1706616	SIGNOR-251128
ERBB2	phosphorylation up-regulates →	ERBB2 PTyr1221	phosphorylation up-regulates →	ERBB2	1706616	SIGNOR-21199
ERBB2	phosphorylation up-regulates →	ERBB2 PTyr1222	phosphorylation up-regulates →	ERBB2	15156151	SIGNOR-124860
ERBB2	phosphorylation up-regulates →	ERBB2 PTyr1023	phosphorylation up-regulates →	ERBB2	1706616	SIGNOR-251129
ERBB2	phosphorylation up-regulates →	ERBB2 PTyr1248	phosphorylation up-regulates →	ERBB2	1706616	SIGNOR-21203
PTPN18	dephosphorylation down-regulates ⊣	ERBB2 PTyr1112	dephosphorylation up-regulates →	ERBB2	25081058	SIGNOR-262595
ERBB2	phosphorylation up-regulates →	ERBB2 PTyr1222	phosphorylation up-regulates →	ERBB2	1706616	SIGNOR-251130
PTPRO	dephosphorylation down-regulates ⊣	ERBB2 PTyr1248	dephosphorylation up-regulates →	ERBB2	27345410	SIGNOR-276979
ERBB2	phosphorylation up-regulates →	ERBB2 PTyr1139	phosphorylation up-regulates →	ERBB2	1706616	SIGNOR-251127
ERBB2	phosphorylation up-regulates →	ERBB2 PTyr1112	phosphorylation down-regulates ⊣	ERBB2	1706616	SIGNOR-21211
PTPN11	dephosphorylation down-regulates ⊣	ERBB2 PTyr1023	dephosphorylation up-regulates →	ERBB2	32024694	SIGNOR-262957
EGFR	phosphorylation up-regulates →	ERBB2 PTyr1248	phosphorylation up-regulates →	ERBB2	12354693	SIGNOR-251094
PTPRG	dephosphorylation down-regulates ⊣	ERBB2 PTyr1248	dephosphorylation down-regulates ⊣	ERBB2	25624455	SIGNOR-254701
PTPN18	dephosphorylation down-regulates ⊣	ERBB2 PTyr1248	dephosphorylation up-regulates →	ERBB2	25081058	SIGNOR-262597
ERBB2	phosphorylation up-regulates →	ERBB2 PTyr1196	phosphorylation up-regulates →	ERBB2	15156151	SIGNOR-124856

Regulator	Mechanism/Effect	Target	SIGNOR-ID
DUSP3	dephosphorylation → down-regulates activity	ERBB2	SIGNOR-248533
DUSP3	dephosphorylation → down-regulates activity	ERBB2	SIGNOR-248534
PTPN12	dephosphorylation → down-regulates activity	ERBB2	SIGNOR-277038
CDK5	phosphorylation → up-regulates activity	ERBB2	SIGNOR-279155
PTPN18	dephosphorylation down-regulates quantity by destabilization	ERBB2	SIGNOR-262596
PTPN18	dephosphorylation down-regulates quantity by destabilization	ERBB2	SIGNOR-277031
PRKACA	phosphorylation → up-regulates	ERBB2	SIGNOR-181191
PTPN13	dephosphorylation → down-regulates activity	ERBB2	SIGNOR-277087
ERBB2	phosphorylation → up-regulates activity	ERBB2	SIGNOR-251128
SRC	phosphorylation → up-regulates activity	ERBB2	SIGNOR-279432
ERBB2	phosphorylation → up-regulates	ERBB2	SIGNOR-21199
ERBB2	phosphorylation → up-regulates	ERBB2	SIGNOR-124860
ERBB2	phosphorylation → up-regulates activity	ERBB2	SIGNOR-251129
ERBB2	phosphorylation → up-regulates	ERBB2	SIGNOR-21203
PTPN18	dephosphorylation down-regulates quantity by destabilization	ERBB2	SIGNOR-262595
ERBB2	phosphorylation → up-regulates activity	ERBB2	SIGNOR-251130
PTPRO	dephosphorylation down-regulates quantity by destabilization	ERBB2	SIGNOR-276979
AREG	phosphorylation → up-regulates	ERBB2	SIGNOR-31199
ERBB2	phosphorylation → up-regulates activity	ERBB2	SIGNOR-251127
JAK2	phosphorylation → up-regulates activity	ERBB2	SIGNOR-279197
ERBB2	phosphorylation down-regulates	ERBB2	SIGNOR-21211
PTPN11	dephosphorylation down-regulates	ERBB2	SIGNOR-262957
EGFR	phosphorylation → up-regulates activity	ERBB2	SIGNOR-251094
PTPRG	dephosphorylation → up-regulates activity	ERBB2	SIGNOR-254701
PTPN18	dephosphorylation down-regulates quantity by destabilization	ERBB2	SIGNOR-262597
ERBB2	phosphorylation → up-regulates	ERBB2	SIGNOR-124856
PTPN9	dephosphorylation → down-regulates activity	ERBB2	SIGNOR-277170
AXL	phosphorylation → down-regulates activity	ERBB2	SIGNOR-280193