| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ERBB2 | ERBB2 | Tyr1221 | SPAFDNLyYWDQDPP | phosphorylation up-regulates | 1706616 | SIGNOR-21199 |
| DUSP3 | ERBB2 | Tyr1221 | SPAFDNLyYWDQDPP | dephosphorylation down-regulates activity | 21262974 | SIGNOR-248534 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ERBB2 | phosphorylation up-regulates → | ERBB2 PTyr1221 | phosphorylation up-regulates → | ERBB2 | 1706616 | SIGNOR-21199 |
| DUSP3 | dephosphorylation down-regulates ⊣ | ERBB2 PTyr1221 | dephosphorylation up-regulates → | ERBB2 | 21262974 | SIGNOR-248534 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ERBB2 | phosphorylation → up-regulates | ERBB2 | SIGNOR-21199 |
| DUSP3 | dephosphorylation → down-regulates activity | ERBB2 | SIGNOR-248534 |
