Entity Details

Name EGFR_Tyr1248
ID P04626
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PTPN18ERBB2Tyr1248PTAENPEyLGLDVPVdephosphorylation
down-regulates quantity by destabilization		25081058SIGNOR-262597
EGFRERBB2Tyr1248PTAENPEyLGLDVPVphosphorylation
up-regulates activity		12354693SIGNOR-251094
PTPROERBB2Tyr1248PTAENPEyLGLDVPVdephosphorylation
down-regulates quantity by destabilization		27345410SIGNOR-276979
ERBB2ERBB2Tyr1248PTAENPEyLGLDVPVphosphorylation
up-regulates		1706616SIGNOR-21203
PTPRGERBB2Tyr1248PTAENPEyLGLDVPVdephosphorylation
up-regulates activity		25624455SIGNOR-254701
ERBB2ERBB2Tyr1248PTAENPEyLGLDVPVphosphorylation
up-regulates activity		1706616SIGNOR-251128
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PTPN18dephosphorylation
down-regulates
⊣
ERBB2
PTyr1248		dephosphorylation
up-regulates
→		ERBB225081058SIGNOR-262597
EGFRphosphorylation
up-regulates
→
ERBB2
PTyr1248		phosphorylation
up-regulates
→		ERBB212354693SIGNOR-251094
PTPROdephosphorylation
down-regulates
⊣
ERBB2
PTyr1248		dephosphorylation
up-regulates
→		ERBB227345410SIGNOR-276979
ERBB2phosphorylation
up-regulates
→
ERBB2
PTyr1248		phosphorylation
up-regulates
→		ERBB21706616SIGNOR-21203
PTPRGdephosphorylation
down-regulates
⊣
ERBB2
PTyr1248		dephosphorylation
down-regulates
⊣		ERBB225624455SIGNOR-254701
ERBB2phosphorylation
up-regulates
→
ERBB2
PTyr1248		phosphorylation
up-regulates
→		ERBB21706616SIGNOR-251128
Regulator Mechanism/Effect Target SIGNOR-ID
PTPN18dephosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		ERBB2SIGNOR-262597
EGFRphosphorylation
→
up-regulates activity 		ERBB2SIGNOR-251094
PTPROdephosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		ERBB2SIGNOR-276979
ERBB2phosphorylation
→
up-regulates 		ERBB2SIGNOR-21203
PTPRGdephosphorylation
→
up-regulates activity 		ERBB2SIGNOR-254701
ERBB2phosphorylation
→
up-regulates activity 		ERBB2SIGNOR-251128