Entity Details

Name PTPN12_Tyr1196
ID P04626
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PTPN18ERBB2Tyr1196GAVENPEyLTPQGGAdephosphorylation
down-regulates quantity by destabilization		25081058SIGNOR-262596
ERBB2ERBB2Tyr1196GAVENPEyLTPQGGAphosphorylation
up-regulates		15156151SIGNOR-124856
PTPN12ERBB2Tyr1196GAVENPEyLTPQGGAdephosphorylation
down-regulates activity		29330094SIGNOR-277038
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PTPN18dephosphorylation
down-regulates
⊣
ERBB2
PTyr1196		dephosphorylation
up-regulates
→		ERBB225081058SIGNOR-262596
ERBB2phosphorylation
up-regulates
→
ERBB2
PTyr1196		phosphorylation
up-regulates
→		ERBB215156151SIGNOR-124856
PTPN12dephosphorylation
down-regulates
⊣
ERBB2
PTyr1196		dephosphorylation
up-regulates
→		ERBB229330094SIGNOR-277038
Regulator Mechanism/Effect Target SIGNOR-ID
PTPN18dephosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		ERBB2SIGNOR-262596
ERBB2phosphorylation
→
up-regulates 		ERBB2SIGNOR-124856
PTPN12dephosphorylation
→
down-regulates activity 		ERBB2SIGNOR-277038