| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK5RAP2 | APP | Thr743 | VEVDAAVtPEERHLS | phosphorylation up-regulates quantity by stabilization | 15178331 | SIGNOR-260818 |
| MAPK8 | APP | Thr743 | VEVDAAVtPEERHLS | phosphorylation up-regulates | 12917434 | SIGNOR-117852 |
| CDK5 | APP | Thr743 | VEVDAAVtPEERHLS | phosphorylation unknown | 10936190 | SIGNOR-250651 |
| CDK2 | APP | Thr743 | VEVDAAVtPEERHLS | phosphorylation down-regulates quantity by destabilization | 30881282 | SIGNOR-280210 |
| CDK4 | APP | Thr743 | VEVDAAVtPEERHLS | phosphorylation down-regulates quantity by destabilization | 30881282 | SIGNOR-280214 |
| MAPK8 | APP | Thr743 | VEVDAAVtPEERHLS | phosphorylation up-regulates | 24610780 | SIGNOR-204679 |
| PLK2 | APP | Thr743 | VEVDAAVtPEERHLS | phosphorylation up-regulates activity | 28257888 | SIGNOR-279424 |
| GSK3B | APP | Thr743 | VEVDAAVtPEERHLS | phosphorylation unknown | 8764598 | SIGNOR-251220 |
| MAPK10 | APP | Thr743 | VEVDAAVtPEERHLS | phosphorylation up-regulates | 24610780 | SIGNOR-204671 |
| DAPK1 | APP | Thr743 | VEVDAAVtPEERHLS | phosphorylation up-regulates quantity | 27094130 | SIGNOR-279518 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK5RAP2 | phosphorylation up-regulates → | APP PThr743 | phosphorylation up-regulates → | APP | 15178331 | SIGNOR-260818 |
| MAPK8 | phosphorylation up-regulates → | APP PThr743 | phosphorylation up-regulates → | APP | 12917434 | SIGNOR-117852 |
| CDK5 | phosphorylation up-regulates → | APP PThr743 | phosphorylation down-regulates ⊣ | APP | 10936190 | SIGNOR-250651 |
| CDK2 | phosphorylation up-regulates → | APP PThr743 | phosphorylation down-regulates ⊣ | APP | 30881282 | SIGNOR-280210 |
| CDK4 | phosphorylation up-regulates → | APP PThr743 | phosphorylation down-regulates ⊣ | APP | 30881282 | SIGNOR-280214 |
| MAPK8 | phosphorylation up-regulates → | APP PThr743 | phosphorylation up-regulates → | APP | 24610780 | SIGNOR-204679 |
| PLK2 | phosphorylation up-regulates → | APP PThr743 | phosphorylation up-regulates → | APP | 28257888 | SIGNOR-279424 |
| GSK3B | phosphorylation up-regulates → | APP PThr743 | phosphorylation down-regulates ⊣ | APP | 8764598 | SIGNOR-251220 |
| MAPK10 | phosphorylation up-regulates → | APP PThr743 | phosphorylation up-regulates → | APP | 24610780 | SIGNOR-204671 |
| DAPK1 | phosphorylation up-regulates → | APP PThr743 | phosphorylation up-regulates → | APP | 27094130 | SIGNOR-279518 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK5RAP2 | phosphorylation → up-regulates quantity by stabilization | APP | SIGNOR-260818 |
| MAPK8 | phosphorylation → up-regulates | APP | SIGNOR-117852 |
| CDK5 | phosphorylation → unknown | APP | SIGNOR-250651 |
| CDK2 | phosphorylation down-regulates quantity by destabilization | APP | SIGNOR-280210 |
| CDK4 | phosphorylation down-regulates quantity by destabilization | APP | SIGNOR-280214 |
| MAPK8 | phosphorylation → up-regulates | APP | SIGNOR-204679 |
| PLK2 | phosphorylation → up-regulates activity | APP | SIGNOR-279424 |
| GSK3B | phosphorylation → unknown | APP | SIGNOR-251220 |
| MAPK10 | phosphorylation → up-regulates | APP | SIGNOR-204671 |
| DAPK1 | phosphorylation → up-regulates quantity | APP | SIGNOR-279518 |
