Entity Details

Name ITGB3
ID P05106
Role substrate
Enzymatic Domains
PSI 30-76

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VWFA 135-377
PubMed|PubMed
I-EGF 1 463-498
PROSITE-ProRule|PubMed
I-EGF 2 499-548
PROSITE-ProRule|PubMed
I-EGF 3 549-585
PROSITE-ProRule|PubMed
I-EGF 4 586-625
PROSITE-ProRule|PubMed
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PDK1ITGB3Thr779LYKEATStFTNITYRphosphorylation
down-regulates activity		10896934SIGNOR-250264
SRCITGB3Tyr785STFTNITyRGTphosphorylation
down-regulates activity		11723131SIGNOR-247207
PDPK1ITGB3Thr779LYKEATStFTNITYRphosphorylation
down-regulates activity		10896934SIGNOR-250266
SRCITGB3Tyr773DTANNPLyKEATSTFphosphorylation
down-regulates activity		11723131SIGNOR-247202
AKT1ITGB3Thr779LYKEATStFTNITYRphosphorylation
down-regulates activity		10896934SIGNOR-252552
AKTITGB3Thr779LYKEATStFTNITYRphosphorylation
down-regulates activity		10896934SIGNOR-251479
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PDK1phosphorylation
up-regulates
→
ITGB3
PThr779		phosphorylation
down-regulates
⊣		ITGB310896934SIGNOR-250264
SRCphosphorylation
up-regulates
→
ITGB3
PTyr785		phosphorylation
down-regulates
⊣		ITGB311723131SIGNOR-247207
PDPK1phosphorylation
up-regulates
→
ITGB3
PThr779		phosphorylation
down-regulates
⊣		ITGB310896934SIGNOR-250266
SRCphosphorylation
up-regulates
→
ITGB3
PTyr773		phosphorylation
down-regulates
⊣		ITGB311723131SIGNOR-247202
AKT1phosphorylation
up-regulates
→
ITGB3
PThr779		phosphorylation
down-regulates
⊣		ITGB310896934SIGNOR-252552
AKTphosphorylation
up-regulates
→
ITGB3
PThr779		phosphorylation
down-regulates
⊣		ITGB310896934SIGNOR-251479
Regulator Mechanism/Effect Target SIGNOR-ID
PDK1phosphorylation
→
down-regulates activity 		ITGB3SIGNOR-250264
SRCphosphorylation
→
down-regulates activity 		ITGB3SIGNOR-247207
PDPK1phosphorylation
→
down-regulates activity 		ITGB3SIGNOR-250266
SRCphosphorylation
→
down-regulates activity 		ITGB3SIGNOR-247202
AKT1phosphorylation
→
down-regulates activity 		ITGB3SIGNOR-252552
AKTphosphorylation
→
down-regulates activity 		ITGB3SIGNOR-251479