| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | ITGB3 | Thr779 | LYKEATStFTNITYR | phosphorylation down-regulates activity | 10896934 | SIGNOR-251479 |
| PDK1 | ITGB3 | Thr779 | LYKEATStFTNITYR | phosphorylation down-regulates activity | 10896934 | SIGNOR-250264 |
| PDPK1 | ITGB3 | Thr779 | LYKEATStFTNITYR | phosphorylation down-regulates activity | 10896934 | SIGNOR-250266 |
| AKT1 | ITGB3 | Thr779 | LYKEATStFTNITYR | phosphorylation down-regulates activity | 10896934 | SIGNOR-252552 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | phosphorylation up-regulates → | ITGB3 PThr779 | phosphorylation down-regulates ⊣ | ITGB3 | 10896934 | SIGNOR-251479 |
| PDK1 | phosphorylation up-regulates → | ITGB3 PThr779 | phosphorylation down-regulates ⊣ | ITGB3 | 10896934 | SIGNOR-250264 |
| PDPK1 | phosphorylation up-regulates → | ITGB3 PThr779 | phosphorylation down-regulates ⊣ | ITGB3 | 10896934 | SIGNOR-250266 |
| AKT1 | phosphorylation up-regulates → | ITGB3 PThr779 | phosphorylation down-regulates ⊣ | ITGB3 | 10896934 | SIGNOR-252552 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT | phosphorylation → down-regulates activity | ITGB3 | SIGNOR-251479 |
| PDK1 | phosphorylation → down-regulates activity | ITGB3 | SIGNOR-250264 |
| PDPK1 | phosphorylation → down-regulates activity | ITGB3 | SIGNOR-250266 |
| AKT1 | phosphorylation → down-regulates activity | ITGB3 | SIGNOR-252552 |