| Name | PRKCG |
| ID | P05129 |
| Role | kinase |
| Enzymatic Domains |
C2 157-275 PROSITE-ProRule
Protein kinase 351-614 PROSITE-ProRule
AGC-kinase C-terminal 615-685 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCG | SDC2 | Ser187 | DLGERKPsSAAYQKA | phosphorylation unknown | 9244383 | SIGNOR-248975 |
| PRKCG | RPS6KB2 | Ser473 | PPSGTKKsKRGRGRP | phosphorylation unknown | 12529391 | SIGNOR-97295 |
| PRKCG | PA2G4 | Thr366 | QSSASRKtQKKKKKK | phosphorylation unknown | 11325528 | SIGNOR-249094 |
| PRKCG | GSTP1 | Ser185 | SAYVGRLsARPKLKA | phosphorylation up-regulates activity | 15604283 | SIGNOR-276019 |
| PRKCG | PA2G4 | Ser363 | ALLQSSAsRKTQKKK | phosphorylation unknown | 11325528 | SIGNOR-249091 |
| PRKCG | CHAT | Ser465 | LKHVTQSsRKLIRAD | phosphorylation up-regulates | 15381704 | SIGNOR-129320 |
| PRKCG | MAPT | Ser324 | RHLSNVSsTGSIDMV | phosphorylation down-regulates activity | 10090741 | SIGNOR-275445 |
| PRKCG | CD5 | Thr436 | FHRNHTAtVRSHAEN | phosphorylation unknown | 11123317 | SIGNOR-249074 |
| PRKCG | HSP90AA1 | Thr115 | GTIAKSGtKAFMEAL | phosphorylation down-regulates | 24117238 | SIGNOR-202812 |
| PRKCG | CYTH2 | Ser392 | AARKKRIsVKKKQEQ | phosphorylation down-regulates activity | 10531036 | SIGNOR-249025 |
| PRKCG | DAB2 | Ser24 | QAAPKAPsKKEKKKG | phosphorylation unknown | 10542228 | SIGNOR-249027 |
| PRKCG | ARHGEF7 | Ser761 | DSLGRRSsLSRLEPS | phosphorylation up-regulates | 25009260 | SIGNOR-205238 |
| PRKCG | HSP90AA1 | Thr603 | PCCIVTStYGWTANM | phosphorylation down-regulates | 24117238 | SIGNOR-202820 |
| PRKCG | CHAT | Ser464 | LLKHVTQsSRKLIRA | phosphorylation up-regulates | 15381704 | SIGNOR-129316 |
| PRKCG | GRK2 | Ser29 | ATPAARAsKKILLPE | phosphorylation up-regulates | 11042191 | SIGNOR-83231 |
| PRKCG | TNNI3 | Ser42 | AKKKSKIsASRKLQL | phosphorylation down-regulates | 15769444 | SIGNOR-134632 |
| PRKCG | PSEN1 | Ser346 | EWEAQRDsHLGPHRS | phosphorylation up-regulates activity | 14576165 | SIGNOR-249238 |
| PRKCG | STK17B | Ser351 | PEDSSMVsKRFRFDD | phosphorylation down-regulates activity | 18084041 | SIGNOR-263178 |
| PRKCG | HABP4 | Thr354 | RKPANDItSQLEINF | phosphorylation down-regulates activity | 14699138 | SIGNOR-249249 |
| PRKCG | TOP2A | Ser29 | EDAKKRLsVERIYQK | phosphorylation up-regulates activity | 12569090 | SIGNOR-249196 |
| PRKCG | MGluR | – | phosphorylation up-regulates activity | 15894802 | SIGNOR-270279 | |
| PRKCG | GRM5 | Thr841 | RSAFTTStVVRMHVG | phosphorylation up-regulates activity | 15894802 | SIGNOR-249289 |
| PRKCG | CHAT | Ser594 | HKAAVPAsEKLLLLK | phosphorylation up-regulates | 15381704 | SIGNOR-129328 |
| PRKCG | GSTP1 | Ser43 | VETWQEGsLKASCLY | phosphorylation up-regulates activity | 15604283 | SIGNOR-276018 |
| PRKCG | AMPA | – | phosphorylation up-regulates | 12536214 | SIGNOR-270233 | |
| PRKCG | SDC2 | Ser188 | LGERKPSsAAYQKAP | phosphorylation unknown | 9244383 | SIGNOR-248978 |
| PRKCG | VTN | Ser381 | RNRKGYRsQRGHSRG | phosphorylation up-regulates quantity by stabilization | 9030777 | SIGNOR-248964 |
| PRKCG | GRIN2B | Ser1323 | ALAPRSVsLKDKGRF | phosphorylation up-regulates activity | 11306676 | SIGNOR-249088 |
| PRKCG | APTX | Thr125 | AKNPGLEtHRKRKRS | phosphorylation up-regulates | 19561170 | SIGNOR-186409 |
| PRKCG | CHAT | Thr373 | TVLVKDStNRDSLDM | phosphorylation up-regulates | 15381704 | SIGNOR-129332 |
| PRKCG | PEBP1 | Ser153 | RGKFKVAsFRKKYEL | phosphorylation up-regulates activity | 12551925 | SIGNOR-249190 |
| PRKCG | HABP4 | Thr375 | GRGARGGtRGGRGRI | phosphorylation down-regulates activity | 14699138 | SIGNOR-249255 |
| PRKCG | GRIN2B | Ser1303 | NKLRRQHsYDTFVDL | phosphorylation up-regulates activity | 11306676 | SIGNOR-249085 |
| PRKCG | EIF4E | Ser209 | DTATKSGsTTKNRFV | phosphorylation unknown | 8662663 | SIGNOR-248947 |
| PRKCG | KIR3DL1 | Ser415 | QRKITRPsQRPKTPP | phosphorylation down-regulates | 17911614 | SIGNOR-158133 |
| PRKCG | GRIN1 | Ser890 | ITSTLASsFKRRRSS | phosphorylation up-regulates activity | 15936117 | SIGNOR-263176 |
| PRKCG | TNNI3 | Ser44 | KKSKISAsRKLQLKT | phosphorylation down-regulates | 15769444 | SIGNOR-134636 |
| PRKCG | HSP90AA1 | Thr425 | KKCLELFtELAEDKE | phosphorylation down-regulates | 24117238 | SIGNOR-202816 |
| PRKCG | CHAT | Ser558 | VPTYESAsIRRFQEG | phosphorylation up-regulates | 15381704 | SIGNOR-129324 |
| PRKCG | RAF1 | Ser619 | SLPKINRsASEPSLH | phosphorylation up-regulates | 8288587 | SIGNOR-37545 |
| PRKCG | GJA1 | Ser368 | QRPSSRAsSRASSRP | phosphorylation down-regulates activity | 10871288 | SIGNOR-249050 |
| PRKCG | OCLN | Ser340 | DKRFYPEsSYKSTPV | phosphorylation up-regulates activity | 11502742 | SIGNOR-249107 |
| PRKCG | NOS3 | Thr495 | TGITRKKtFKEVANA | phosphorylation down-regulates activity | 24379783 | SIGNOR-251633 |
| PRKCG | GRIA4 | Ser862 | IRNKARLsITGSVGE | phosphorylation up-regulates | 12536214 | SIGNOR-97558 |
| PRKCG | GRK2 | Ser29 | ATPAARAsKKILLPE | phosphorylation up-regulates activity | 11042191 | SIGNOR-249060 |
| PRKCG | NRGN | Ser36 | AAAKIQAsFRGHMAR | phosphorylation up-regulates activity | 8080473 | SIGNOR-248915 |
| PRKCG | ANXA1 | Ser27 | EYVQTVKsSKGGPGS | phosphorylation up-regulates | 24103589 | SIGNOR-202788 |
| PRKCG | GRM5 | Ser840 | VRSAFTTsTVVRMHV | phosphorylation up-regulates activity | 15894802 | SIGNOR-249282 |
| PRKCG | ARHGEF7 | Ser518 | LSASPRMsGFIYQGK | phosphorylation up-regulates | 25009260 | SIGNOR-205234 |
| PRKCG | CD5 | Thr436 | FHRNHTAtVRSHAEN | phosphorylation up-regulates | 11123317 | SIGNOR-85183 |
| PRKCG | CD5 | Thr434 | MSFHRNHtATVRSHA | phosphorylation unknown | 11123317 | SIGNOR-249072 |
| PRKCG | STXBP1 | Ser306 | VSQEVTRsLKDFSSS | phosphorylation unknown | 12519779 | SIGNOR-249184 |
| PRKCG | STXBP1 | Ser313 | SLKDFSSsKRMNTGE | phosphorylation down-regulates activity | 12519779 | SIGNOR-249187 |
| PRKCG | RAF1 | Ser497 | ATVKSRWsGSQQVEQ | phosphorylation up-regulates | 8288587 | SIGNOR-37541 |
| PRKCG | GSK3A | Ser21 | SGRARTSsFAEPGGG | phosphorylation down-regulates | 11884598 | SIGNOR-115726 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCG | phosphorylation up-regulates → | SDC2 PSer187 | phosphorylation down-regulates ⊣ | SDC2 | 9244383 | SIGNOR-248975 |
| PRKCG | phosphorylation up-regulates → | RPS6KB2 PSer473 | phosphorylation down-regulates ⊣ | RPS6KB2 | 12529391 | SIGNOR-97295 |
| PRKCG | phosphorylation up-regulates → | PA2G4 PThr366 | phosphorylation down-regulates ⊣ | PA2G4 | 11325528 | SIGNOR-249094 |
| PRKCG | phosphorylation up-regulates → | GSTP1 PSer185 | phosphorylation up-regulates → | GSTP1 | 15604283 | SIGNOR-276019 |
| PRKCG | phosphorylation up-regulates → | PA2G4 PSer363 | phosphorylation down-regulates ⊣ | PA2G4 | 11325528 | SIGNOR-249091 |
| PRKCG | phosphorylation up-regulates → | CHAT PSer465 | phosphorylation up-regulates → | CHAT | 15381704 | SIGNOR-129320 |
| PRKCG | phosphorylation up-regulates → | MAPT PSer324 | phosphorylation down-regulates ⊣ | MAPT | 10090741 | SIGNOR-275445 |
| PRKCG | phosphorylation up-regulates → | CD5 PThr436 | phosphorylation down-regulates ⊣ | CD5 | 11123317 | SIGNOR-249074 |
| PRKCG | phosphorylation up-regulates → | HSP90AA1 PThr115 | phosphorylation down-regulates ⊣ | HSP90AA1 | 24117238 | SIGNOR-202812 |
| PRKCG | phosphorylation up-regulates → | CYTH2 PSer392 | phosphorylation down-regulates ⊣ | CYTH2 | 10531036 | SIGNOR-249025 |
| PRKCG | phosphorylation up-regulates → | DAB2 PSer24 | phosphorylation down-regulates ⊣ | DAB2 | 10542228 | SIGNOR-249027 |
| PRKCG | phosphorylation up-regulates → | ARHGEF7 PSer761 | phosphorylation up-regulates → | ARHGEF7 | 25009260 | SIGNOR-205238 |
| PRKCG | phosphorylation up-regulates → | HSP90AA1 PThr603 | phosphorylation down-regulates ⊣ | HSP90AA1 | 24117238 | SIGNOR-202820 |
| PRKCG | phosphorylation up-regulates → | CHAT PSer464 | phosphorylation up-regulates → | CHAT | 15381704 | SIGNOR-129316 |
| PRKCG | phosphorylation up-regulates → | GRK2 PSer29 | phosphorylation up-regulates → | GRK2 | 11042191 | SIGNOR-83231 |
| PRKCG | phosphorylation up-regulates → | TNNI3 PSer42 | phosphorylation down-regulates ⊣ | TNNI3 | 15769444 | SIGNOR-134632 |
| PRKCG | phosphorylation up-regulates → | PSEN1 PSer346 | phosphorylation up-regulates → | PSEN1 | 14576165 | SIGNOR-249238 |
| PRKCG | phosphorylation up-regulates → | STK17B PSer351 | phosphorylation down-regulates ⊣ | STK17B | 18084041 | SIGNOR-263178 |
| PRKCG | phosphorylation up-regulates → | HABP4 PThr354 | phosphorylation down-regulates ⊣ | HABP4 | 14699138 | SIGNOR-249249 |
| PRKCG | phosphorylation up-regulates → | TOP2A PSer29 | phosphorylation up-regulates → | TOP2A | 12569090 | SIGNOR-249196 |
| PRKCG | phosphorylation up-regulates → | GRM5 PThr841 | phosphorylation up-regulates → | GRM5 | 15894802 | SIGNOR-249289 |
| PRKCG | phosphorylation up-regulates → | CHAT PSer594 | phosphorylation up-regulates → | CHAT | 15381704 | SIGNOR-129328 |
| PRKCG | phosphorylation up-regulates → | GSTP1 PSer43 | phosphorylation up-regulates → | GSTP1 | 15604283 | SIGNOR-276018 |
| PRKCG | phosphorylation up-regulates → | SDC2 PSer188 | phosphorylation down-regulates ⊣ | SDC2 | 9244383 | SIGNOR-248978 |
| PRKCG | phosphorylation up-regulates → | VTN PSer381 | phosphorylation up-regulates → | VTN | 9030777 | SIGNOR-248964 |
| PRKCG | phosphorylation up-regulates → | GRIN2B PSer1323 | phosphorylation up-regulates → | GRIN2B | 11306676 | SIGNOR-249088 |
| PRKCG | phosphorylation up-regulates → | APTX PThr125 | phosphorylation up-regulates → | APTX | 19561170 | SIGNOR-186409 |
| PRKCG | phosphorylation up-regulates → | CHAT PThr373 | phosphorylation up-regulates → | CHAT | 15381704 | SIGNOR-129332 |
| PRKCG | phosphorylation up-regulates → | PEBP1 PSer153 | phosphorylation up-regulates → | PEBP1 | 12551925 | SIGNOR-249190 |
| PRKCG | phosphorylation up-regulates → | HABP4 PThr375 | phosphorylation down-regulates ⊣ | HABP4 | 14699138 | SIGNOR-249255 |
| PRKCG | phosphorylation up-regulates → | GRIN2B PSer1303 | phosphorylation up-regulates → | GRIN2B | 11306676 | SIGNOR-249085 |
| PRKCG | phosphorylation up-regulates → | EIF4E PSer209 | phosphorylation down-regulates ⊣ | EIF4E | 8662663 | SIGNOR-248947 |
| PRKCG | phosphorylation up-regulates → | KIR3DL1 PSer415 | phosphorylation down-regulates ⊣ | KIR3DL1 | 17911614 | SIGNOR-158133 |
| PRKCG | phosphorylation up-regulates → | GRIN1 PSer890 | phosphorylation up-regulates → | GRIN1 | 15936117 | SIGNOR-263176 |
| PRKCG | phosphorylation up-regulates → | TNNI3 PSer44 | phosphorylation down-regulates ⊣ | TNNI3 | 15769444 | SIGNOR-134636 |
| PRKCG | phosphorylation up-regulates → | HSP90AA1 PThr425 | phosphorylation down-regulates ⊣ | HSP90AA1 | 24117238 | SIGNOR-202816 |
| PRKCG | phosphorylation up-regulates → | CHAT PSer558 | phosphorylation up-regulates → | CHAT | 15381704 | SIGNOR-129324 |
| PRKCG | phosphorylation up-regulates → | RAF1 PSer619 | phosphorylation up-regulates → | RAF1 | 8288587 | SIGNOR-37545 |
| PRKCG | phosphorylation up-regulates → | GJA1 PSer368 | phosphorylation down-regulates ⊣ | GJA1 | 10871288 | SIGNOR-249050 |
| PRKCG | phosphorylation up-regulates → | OCLN PSer340 | phosphorylation up-regulates → | OCLN | 11502742 | SIGNOR-249107 |
| PRKCG | phosphorylation up-regulates → | NOS3 PThr495 | phosphorylation down-regulates ⊣ | NOS3 | 24379783 | SIGNOR-251633 |
| PRKCG | phosphorylation up-regulates → | GRIA4 PSer862 | phosphorylation up-regulates → | GRIA4 | 12536214 | SIGNOR-97558 |
| PRKCG | phosphorylation up-regulates → | GRK2 PSer29 | phosphorylation up-regulates → | GRK2 | 11042191 | SIGNOR-249060 |
| PRKCG | phosphorylation up-regulates → | NRGN PSer36 | phosphorylation up-regulates → | NRGN | 8080473 | SIGNOR-248915 |
| PRKCG | phosphorylation up-regulates → | ANXA1 PSer27 | phosphorylation up-regulates → | ANXA1 | 24103589 | SIGNOR-202788 |
| PRKCG | phosphorylation up-regulates → | GRM5 PSer840 | phosphorylation up-regulates → | GRM5 | 15894802 | SIGNOR-249282 |
| PRKCG | phosphorylation up-regulates → | ARHGEF7 PSer518 | phosphorylation up-regulates → | ARHGEF7 | 25009260 | SIGNOR-205234 |
| PRKCG | phosphorylation up-regulates → | CD5 PThr436 | phosphorylation up-regulates → | CD5 | 11123317 | SIGNOR-85183 |
| PRKCG | phosphorylation up-regulates → | CD5 PThr434 | phosphorylation down-regulates ⊣ | CD5 | 11123317 | SIGNOR-249072 |
| PRKCG | phosphorylation up-regulates → | STXBP1 PSer306 | phosphorylation down-regulates ⊣ | STXBP1 | 12519779 | SIGNOR-249184 |
| PRKCG | phosphorylation up-regulates → | STXBP1 PSer313 | phosphorylation down-regulates ⊣ | STXBP1 | 12519779 | SIGNOR-249187 |
| PRKCG | phosphorylation up-regulates → | RAF1 PSer497 | phosphorylation up-regulates → | RAF1 | 8288587 | SIGNOR-37541 |
| PRKCG | phosphorylation up-regulates → | GSK3A PSer21 | phosphorylation down-regulates ⊣ | GSK3A | 11884598 | SIGNOR-115726 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCG | phosphorylation → unknown | SDC2 | SIGNOR-248975 |
| PRKCG | phosphorylation → unknown | RPS6KB2 | SIGNOR-97295 |
| PRKCG | phosphorylation → unknown | PA2G4 | SIGNOR-249094 |
| PRKCG | phosphorylation → up-regulates activity | GSTP1 | SIGNOR-276019 |
| PRKCG | phosphorylation → unknown | PA2G4 | SIGNOR-249091 |
| PRKCG | phosphorylation → up-regulates | CHAT | SIGNOR-129320 |
| PRKCG | phosphorylation → down-regulates activity | MAPT | SIGNOR-275445 |
| PRKCG | phosphorylation → unknown | CD5 | SIGNOR-249074 |
| PRKCG | phosphorylation down-regulates | HSP90AA1 | SIGNOR-202812 |
| PRKCG | phosphorylation → down-regulates activity | CYTH2 | SIGNOR-249025 |
| PRKCG | phosphorylation → unknown | DAB2 | SIGNOR-249027 |
| PRKCG | phosphorylation → up-regulates | ARHGEF7 | SIGNOR-205238 |
| PRKCG | phosphorylation down-regulates | HSP90AA1 | SIGNOR-202820 |
| PRKCG | phosphorylation → up-regulates | CHAT | SIGNOR-129316 |
| PRKCG | phosphorylation → up-regulates | GRK2 | SIGNOR-83231 |
| PRKCG | phosphorylation down-regulates | TNNI3 | SIGNOR-134632 |
| PRKCG | phosphorylation → up-regulates activity | PSEN1 | SIGNOR-249238 |
| PRKCG | phosphorylation → down-regulates activity | STK17B | SIGNOR-263178 |
| PRKCG | phosphorylation → down-regulates activity | HABP4 | SIGNOR-249249 |
| PRKCG | phosphorylation → up-regulates activity | TOP2A | SIGNOR-249196 |
| PRKCG | phosphorylation → up-regulates activity | MGluR | SIGNOR-270279 |
| PRKCG | phosphorylation → up-regulates activity | GRM5 | SIGNOR-249289 |
| PRKCG | phosphorylation → up-regulates | CHAT | SIGNOR-129328 |
| PRKCG | phosphorylation → up-regulates activity | GSTP1 | SIGNOR-276018 |
| PRKCG | phosphorylation → up-regulates | AMPA | SIGNOR-270233 |
| PRKCG | phosphorylation → unknown | SDC2 | SIGNOR-248978 |
| PRKCG | phosphorylation → up-regulates quantity by stabilization | VTN | SIGNOR-248964 |
| PRKCG | phosphorylation → up-regulates activity | GRIN2B | SIGNOR-249088 |
| PRKCG | phosphorylation → up-regulates | APTX | SIGNOR-186409 |
| PRKCG | phosphorylation → up-regulates | CHAT | SIGNOR-129332 |
| PRKCG | phosphorylation → up-regulates activity | PEBP1 | SIGNOR-249190 |
| PRKCG | phosphorylation → down-regulates activity | HABP4 | SIGNOR-249255 |
| PRKCG | phosphorylation → up-regulates activity | GRIN2B | SIGNOR-249085 |
| PRKCG | phosphorylation → unknown | EIF4E | SIGNOR-248947 |
| PRKCG | phosphorylation down-regulates | KIR3DL1 | SIGNOR-158133 |
| PRKCG | phosphorylation → up-regulates activity | GRIN1 | SIGNOR-263176 |
| PRKCG | phosphorylation down-regulates | TNNI3 | SIGNOR-134636 |
| PRKCG | phosphorylation down-regulates | HSP90AA1 | SIGNOR-202816 |
| PRKCG | phosphorylation → up-regulates | CHAT | SIGNOR-129324 |
| PRKCG | phosphorylation → up-regulates | RAF1 | SIGNOR-37545 |
| PRKCG | phosphorylation → down-regulates activity | GJA1 | SIGNOR-249050 |
| PRKCG | phosphorylation → up-regulates activity | OCLN | SIGNOR-249107 |
| PRKCG | phosphorylation → down-regulates activity | NOS3 | SIGNOR-251633 |
| PRKCG | phosphorylation → up-regulates | GRIA4 | SIGNOR-97558 |
| PRKCG | phosphorylation → up-regulates activity | GRK2 | SIGNOR-249060 |
| PRKCG | phosphorylation → up-regulates activity | NRGN | SIGNOR-248915 |
| PRKCG | phosphorylation → up-regulates | ANXA1 | SIGNOR-202788 |
| PRKCG | phosphorylation → up-regulates activity | GRM5 | SIGNOR-249282 |
| PRKCG | phosphorylation → up-regulates | ARHGEF7 | SIGNOR-205234 |
| PRKCG | phosphorylation → up-regulates | CD5 | SIGNOR-85183 |
| PRKCG | phosphorylation → unknown | CD5 | SIGNOR-249072 |
| PRKCG | phosphorylation → unknown | STXBP1 | SIGNOR-249184 |
| PRKCG | phosphorylation → down-regulates activity | STXBP1 | SIGNOR-249187 |
| PRKCG | phosphorylation → up-regulates | RAF1 | SIGNOR-37541 |
| PRKCG | phosphorylation down-regulates | GSK3A | SIGNOR-115726 |