| Name | PRKCB |
| ID | P05771 |
| Role | substrate |
| Enzymatic Domains |
C2 158-275 PROSITE-ProRule
Protein kinase 342-600 PROSITE-ProRule
AGC-kinase C-terminal 601-671 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PHLPP2 | PRKCB | Ser661 | QNEFAGFsYTNPEFV | dephosphorylation down-regulates quantity | 18162466 | SIGNOR-237039 |
| PRKCB | PRKCB | Thr17 | PSEGEEStVRFARKG | phosphorylation unknown | 2377895 | SIGNOR-248868 |
| PRKCB | PRKCB | Ser16 | PPSEGEEsTVRFARK | phosphorylation unknown | 2377895 | SIGNOR-248863 |
| PPP2CB | PRKCB | Thr500 | WDGVTTKtFCGTPDY | dephosphorylation down-regulates activity | 8749392 | SIGNOR-248585 |
| PHLPP1 | PRKCB | Ser661 | QNEFAGFsYTNPEFV | dephosphorylation down-regulates quantity | 18162466 | SIGNOR-237047 |
| BLVRA | PRKCB | Thr500 | WDGVTTKtFCGTPDY | phosphorylation up-regulates | 17227757 | SIGNOR-152181 |
| PRKCB | PRKCB | Ser661 | QNEFAGFsYTNPEFV | phosphorylation up-regulates activity | 10828076 | SIGNOR-77583 |
| PHLPP1 | PRKCB | Ser661 | QNEFAGFsYTNPEFV | dephosphorylation down-regulates quantity by destabilization | 18162466 | SIGNOR-248326 |
| PRKCB | PRKCB | Thr642 | TRQPVELtPTDKLFI | phosphorylation up-regulates | 17115692 | SIGNOR-150865 |
| PHLPP2 | PRKCB | Ser661 | QNEFAGFsYTNPEFV | dephosphorylation down-regulates quantity by destabilization | 18162466 | SIGNOR-248727 |
| PRKCB | PRKCB | Ser661 | QNEFAGFsYTNPEFV | phosphorylation up-regulates activity | 17115692 | SIGNOR-150861 |
| PPP2CA | PRKCB | Thr500 | WDGVTTKtFCGTPDY | dephosphorylation down-regulates activity | 8749392 | SIGNOR-248620 |
| PDPK1 | PRKCB | Thr500 | WDGVTTKtFCGTPDY | phosphorylation up-regulates | 17115692 | SIGNOR-150857 |
| PDPK1 | PRKCB | – | phosphorylation up-regulates | 15209375 | SIGNOR-126069 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PHLPP2 | dephosphorylation down-regulates ⊣ | PRKCB PSer661 | dephosphorylation up-regulates → | PRKCB | 18162466 | SIGNOR-237039 |
| PRKCB | phosphorylation up-regulates → | PRKCB PThr17 | phosphorylation down-regulates ⊣ | PRKCB | 2377895 | SIGNOR-248868 |
| PRKCB | phosphorylation up-regulates → | PRKCB PSer16 | phosphorylation down-regulates ⊣ | PRKCB | 2377895 | SIGNOR-248863 |
| PPP2CB | dephosphorylation down-regulates ⊣ | PRKCB PThr500 | dephosphorylation up-regulates → | PRKCB | 8749392 | SIGNOR-248585 |
| PHLPP1 | dephosphorylation down-regulates ⊣ | PRKCB PSer661 | dephosphorylation up-regulates → | PRKCB | 18162466 | SIGNOR-237047 |
| BLVRA | phosphorylation up-regulates → | PRKCB PThr500 | phosphorylation up-regulates → | PRKCB | 17227757 | SIGNOR-152181 |
| PRKCB | phosphorylation up-regulates → | PRKCB PSer661 | phosphorylation up-regulates → | PRKCB | 10828076 | SIGNOR-77583 |
| PHLPP1 | dephosphorylation down-regulates ⊣ | PRKCB PSer661 | dephosphorylation up-regulates → | PRKCB | 18162466 | SIGNOR-248326 |
| PRKCB | phosphorylation up-regulates → | PRKCB PThr642 | phosphorylation up-regulates → | PRKCB | 17115692 | SIGNOR-150865 |
| PHLPP2 | dephosphorylation down-regulates ⊣ | PRKCB PSer661 | dephosphorylation up-regulates → | PRKCB | 18162466 | SIGNOR-248727 |
| PRKCB | phosphorylation up-regulates → | PRKCB PSer661 | phosphorylation up-regulates → | PRKCB | 17115692 | SIGNOR-150861 |
| PPP2CA | dephosphorylation down-regulates ⊣ | PRKCB PThr500 | dephosphorylation up-regulates → | PRKCB | 8749392 | SIGNOR-248620 |
| PDPK1 | phosphorylation up-regulates → | PRKCB PThr500 | phosphorylation up-regulates → | PRKCB | 17115692 | SIGNOR-150857 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PHLPP2 | dephosphorylation → down-regulates quantity | PRKCB | SIGNOR-237039 |
| PRKCB | phosphorylation → unknown | PRKCB | SIGNOR-248868 |
| PRKCB | phosphorylation → unknown | PRKCB | SIGNOR-248863 |
| PPP2CB | dephosphorylation → down-regulates activity | PRKCB | SIGNOR-248585 |
| PHLPP1 | dephosphorylation → down-regulates quantity | PRKCB | SIGNOR-237047 |
| BLVRA | phosphorylation → up-regulates | PRKCB | SIGNOR-152181 |
| PRKCB | phosphorylation → up-regulates activity | PRKCB | SIGNOR-77583 |
| PHLPP1 | dephosphorylation![]() down-regulates quantity by destabilization | PRKCB | SIGNOR-248326 |
| PRKCB | phosphorylation → up-regulates | PRKCB | SIGNOR-150865 |
| PHLPP2 | dephosphorylation![]() down-regulates quantity by destabilization | PRKCB | SIGNOR-248727 |
| PRKCB | phosphorylation → up-regulates activity | PRKCB | SIGNOR-150861 |
| PPP2CA | dephosphorylation → down-regulates activity | PRKCB | SIGNOR-248620 |
| PDPK1 | phosphorylation → up-regulates | PRKCB | SIGNOR-150857 |
| PDPK1 | phosphorylation → up-regulates | PRKCB | SIGNOR-126069 |