Entity Details

Name PRKCB
ID P05771
Role substrate
Enzymatic Domains
C2 158-275
PROSITE-ProRule
Protein kinase 342-600
PROSITE-ProRule
AGC-kinase C-terminal 601-671
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PHLPP2PRKCBSer661QNEFAGFsYTNPEFVdephosphorylation
down-regulates quantity
18162466SIGNOR-237039
PRKCBPRKCBThr17PSEGEEStVRFARKGphosphorylation
unknown
2377895SIGNOR-248868
PRKCBPRKCBSer16PPSEGEEsTVRFARKphosphorylation
unknown
2377895SIGNOR-248863
PPP2CBPRKCBThr500 WDGVTTKtFCGTPDYdephosphorylation
down-regulates activity
8749392SIGNOR-248585
PHLPP1PRKCBSer661QNEFAGFsYTNPEFVdephosphorylation
down-regulates quantity
18162466SIGNOR-237047
BLVRAPRKCBThr500 WDGVTTKtFCGTPDYphosphorylation
up-regulates
17227757SIGNOR-152181
PRKCBPRKCBSer661QNEFAGFsYTNPEFVphosphorylation
up-regulates activity
10828076SIGNOR-77583
PHLPP1PRKCBSer661QNEFAGFsYTNPEFVdephosphorylation
down-regulates quantity by destabilization
18162466SIGNOR-248326
PRKCBPRKCBThr642 TRQPVELtPTDKLFIphosphorylation
up-regulates
17115692SIGNOR-150865
PHLPP2PRKCBSer661QNEFAGFsYTNPEFVdephosphorylation
down-regulates quantity by destabilization
18162466SIGNOR-248727
PRKCBPRKCBSer661QNEFAGFsYTNPEFVphosphorylation
up-regulates activity
17115692SIGNOR-150861
PPP2CAPRKCBThr500 WDGVTTKtFCGTPDYdephosphorylation
down-regulates activity
8749392SIGNOR-248620
PDPK1PRKCBThr500 WDGVTTKtFCGTPDYphosphorylation
up-regulates
17115692SIGNOR-150857
PDPK1PRKCBphosphorylation
up-regulates
15209375SIGNOR-126069
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PHLPP2dephosphorylation
down-regulates
PRKCB
PSer661
dephosphorylation
up-regulates
PRKCB18162466SIGNOR-237039
PRKCBphosphorylation
up-regulates
PRKCB
PThr17
phosphorylation
down-regulates
PRKCB2377895SIGNOR-248868
PRKCBphosphorylation
up-regulates
PRKCB
PSer16
phosphorylation
down-regulates
PRKCB2377895SIGNOR-248863
PPP2CBdephosphorylation
down-regulates
PRKCB
PThr500
dephosphorylation
up-regulates
PRKCB8749392SIGNOR-248585
PHLPP1dephosphorylation
down-regulates
PRKCB
PSer661
dephosphorylation
up-regulates
PRKCB18162466SIGNOR-237047
BLVRAphosphorylation
up-regulates
PRKCB
PThr500
phosphorylation
up-regulates
PRKCB17227757SIGNOR-152181
PRKCBphosphorylation
up-regulates
PRKCB
PSer661
phosphorylation
up-regulates
PRKCB10828076SIGNOR-77583
PHLPP1dephosphorylation
down-regulates
PRKCB
PSer661
dephosphorylation
up-regulates
PRKCB18162466SIGNOR-248326
PRKCBphosphorylation
up-regulates
PRKCB
PThr642
phosphorylation
up-regulates
PRKCB17115692SIGNOR-150865
PHLPP2dephosphorylation
down-regulates
PRKCB
PSer661
dephosphorylation
up-regulates
PRKCB18162466SIGNOR-248727
PRKCBphosphorylation
up-regulates
PRKCB
PSer661
phosphorylation
up-regulates
PRKCB17115692SIGNOR-150861
PPP2CAdephosphorylation
down-regulates
PRKCB
PThr500
dephosphorylation
up-regulates
PRKCB8749392SIGNOR-248620
PDPK1phosphorylation
up-regulates
PRKCB
PThr500
phosphorylation
up-regulates
PRKCB17115692SIGNOR-150857
Regulator Mechanism/Effect Target SIGNOR-ID
PHLPP2dephosphorylation

down-regulates quantity
PRKCBSIGNOR-237039
PRKCBphosphorylation

unknown
PRKCBSIGNOR-248868
PRKCBphosphorylation

unknown
PRKCBSIGNOR-248863
PPP2CBdephosphorylation

down-regulates activity
PRKCBSIGNOR-248585
PHLPP1dephosphorylation

down-regulates quantity
PRKCBSIGNOR-237047
BLVRAphosphorylation

up-regulates
PRKCBSIGNOR-152181
PRKCBphosphorylation

up-regulates activity
PRKCBSIGNOR-77583
PHLPP1dephosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
PRKCBSIGNOR-248326
PRKCBphosphorylation

up-regulates
PRKCBSIGNOR-150865
PHLPP2dephosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
PRKCBSIGNOR-248727
PRKCBphosphorylation

up-regulates activity
PRKCBSIGNOR-150861
PPP2CAdephosphorylation

down-regulates activity
PRKCBSIGNOR-248620
PDPK1phosphorylation

up-regulates
PRKCBSIGNOR-150857
PDPK1phosphorylation

up-regulates
PRKCBSIGNOR-126069