| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PHLPP2 | PRKCB | Ser661 | QNEFAGFsYTNPEFV | dephosphorylation down-regulates quantity | 18162466 | SIGNOR-237039 |
| PHLPP1 | PRKCB | Ser661 | QNEFAGFsYTNPEFV | dephosphorylation down-regulates quantity | 18162466 | SIGNOR-237047 |
| PRKCB | PRKCB | Ser661 | QNEFAGFsYTNPEFV | phosphorylation up-regulates activity | 10828076 | SIGNOR-77583 |
| PHLPP1 | PRKCB | Ser661 | QNEFAGFsYTNPEFV | dephosphorylation down-regulates quantity by destabilization | 18162466 | SIGNOR-248326 |
| PHLPP2 | PRKCB | Ser661 | QNEFAGFsYTNPEFV | dephosphorylation down-regulates quantity by destabilization | 18162466 | SIGNOR-248727 |
| PRKCB | PRKCB | Ser661 | QNEFAGFsYTNPEFV | phosphorylation up-regulates activity | 17115692 | SIGNOR-150861 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PHLPP2 | dephosphorylation down-regulates ⊣ | PRKCB PSer661 | dephosphorylation up-regulates → | PRKCB | 18162466 | SIGNOR-237039 |
| PHLPP1 | dephosphorylation down-regulates ⊣ | PRKCB PSer661 | dephosphorylation up-regulates → | PRKCB | 18162466 | SIGNOR-237047 |
| PRKCB | phosphorylation up-regulates → | PRKCB PSer661 | phosphorylation up-regulates → | PRKCB | 10828076 | SIGNOR-77583 |
| PHLPP1 | dephosphorylation down-regulates ⊣ | PRKCB PSer661 | dephosphorylation up-regulates → | PRKCB | 18162466 | SIGNOR-248326 |
| PHLPP2 | dephosphorylation down-regulates ⊣ | PRKCB PSer661 | dephosphorylation up-regulates → | PRKCB | 18162466 | SIGNOR-248727 |
| PRKCB | phosphorylation up-regulates → | PRKCB PSer661 | phosphorylation up-regulates → | PRKCB | 17115692 | SIGNOR-150861 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PHLPP2 | dephosphorylation → down-regulates quantity | PRKCB | SIGNOR-237039 |
| PHLPP1 | dephosphorylation → down-regulates quantity | PRKCB | SIGNOR-237047 |
| PRKCB | phosphorylation → up-regulates activity | PRKCB | SIGNOR-77583 |
| PHLPP1 | dephosphorylation down-regulates quantity by destabilization | PRKCB | SIGNOR-248326 |
| PHLPP2 | dephosphorylation down-regulates quantity by destabilization | PRKCB | SIGNOR-248727 |
| PRKCB | phosphorylation → up-regulates activity | PRKCB | SIGNOR-150861 |
