| Name | KRT8 |
| ID | P05787 |
| Role | substrate |
| Enzymatic Domains |
IF rod 91-402 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | KRT8 | Ser432 | SAYGGLTsPGLSYSL | phosphorylation up-regulates | 9524113 | SIGNOR-56054 |
| ERK1/2 | KRT8 | – | phosphorylation unknown | 16554440 | SIGNOR-270135 | |
| MAPK8 | KRT8 | Ser74 | TVNQSLLsPLVLEVD | phosphorylation up-regulates | 11788583 | SIGNOR-114083 |
| PTPN1 | KRT8 | Tyr267 | IAEVKAQyEDIANRS | dephosphorylation down-regulates activity | 24003221 | SIGNOR-265495 |
| MAPK1 | KRT8 | Ser432 | SAYGGLTsPGLSYSL | phosphorylation unknown | 16554440 | SIGNOR-249411 |
| p38 | KRT8 | – | phosphorylation up-regulates | 11788583 | SIGNOR-270125 | |
| MAPK11 | KRT8 | Ser74 | TVNQSLLsPLVLEVD | phosphorylation up-regulates | 11788583 | SIGNOR-114063 |
| Gbeta | KRT8 | – | phosphorylation unknown | 16554440 | SIGNOR-270003 | |
| PPP2CB | KRT8 | Ser432 | SAYGGLTsPGLSYSL | dephosphorylation unknown | 16554440 | SIGNOR-248588 |
| MAPK14 | KRT8 | Ser74 | TVNQSLLsPLVLEVD | phosphorylation up-regulates | 11788583 | SIGNOR-114079 |
| MAPK3 | KRT8 | Ser432 | SAYGGLTsPGLSYSL | phosphorylation unknown | 16554440 | SIGNOR-249468 |
| PTP4A3 | KRT8 | Ser432 | SAYGGLTsPGLSYSL | dephosphorylation down-regulates activity | 19115206 | SIGNOR-248341 |
| MAPK12 | KRT8 | Ser74 | TVNQSLLsPLVLEVD | phosphorylation up-regulates | 11788583 | SIGNOR-114067 |
| MAPK3 | KRT8 | Ser432 | SAYGGLTsPGLSYSL | phosphorylation unknown | 22344252 | SIGNOR-196141 |
| PPP2CA | KRT8 | Ser432 | SAYGGLTsPGLSYSL | dephosphorylation unknown | 16554440 | SIGNOR-248623 |
| MAPK13 | KRT8 | Ser74 | TVNQSLLsPLVLEVD | phosphorylation up-regulates | 11788583 | SIGNOR-114075 |
| PTP4A3 | KRT8 | Ser74 | TVNQSLLsPLVLEVD | dephosphorylation down-regulates activity | 19115206 | SIGNOR-248340 |
| MAPK8 | KRT8 | Ser74 | TVNQSLLsPLVLEVD | phosphorylation up-regulates | 11781324 | SIGNOR-113645 |
| PRKCD | KRT8 | Ser74 | TVNQSLLsPLVLEVD | phosphorylation up-regulates | 15972820 | SIGNOR-260887 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | phosphorylation up-regulates → | KRT8 PSer432 | phosphorylation up-regulates → | KRT8 | 9524113 | SIGNOR-56054 |
| MAPK8 | phosphorylation up-regulates → | KRT8 PSer74 | phosphorylation up-regulates → | KRT8 | 11788583 | SIGNOR-114083 |
| PTPN1 | dephosphorylation down-regulates ⊣ | KRT8 PTyr267 | dephosphorylation up-regulates → | KRT8 | 24003221 | SIGNOR-265495 |
| MAPK1 | phosphorylation up-regulates → | KRT8 PSer432 | phosphorylation down-regulates ⊣ | KRT8 | 16554440 | SIGNOR-249411 |
| MAPK11 | phosphorylation up-regulates → | KRT8 PSer74 | phosphorylation up-regulates → | KRT8 | 11788583 | SIGNOR-114063 |
| PPP2CB | dephosphorylation down-regulates ⊣ | KRT8 PSer432 | dephosphorylation up-regulates → | KRT8 | 16554440 | SIGNOR-248588 |
| MAPK14 | phosphorylation up-regulates → | KRT8 PSer74 | phosphorylation up-regulates → | KRT8 | 11788583 | SIGNOR-114079 |
| MAPK3 | phosphorylation up-regulates → | KRT8 PSer432 | phosphorylation down-regulates ⊣ | KRT8 | 16554440 | SIGNOR-249468 |
| PTP4A3 | dephosphorylation down-regulates ⊣ | KRT8 PSer432 | dephosphorylation up-regulates → | KRT8 | 19115206 | SIGNOR-248341 |
| MAPK12 | phosphorylation up-regulates → | KRT8 PSer74 | phosphorylation up-regulates → | KRT8 | 11788583 | SIGNOR-114067 |
| MAPK3 | phosphorylation up-regulates → | KRT8 PSer432 | phosphorylation down-regulates ⊣ | KRT8 | 22344252 | SIGNOR-196141 |
| PPP2CA | dephosphorylation down-regulates ⊣ | KRT8 PSer432 | dephosphorylation up-regulates → | KRT8 | 16554440 | SIGNOR-248623 |
| MAPK13 | phosphorylation up-regulates → | KRT8 PSer74 | phosphorylation up-regulates → | KRT8 | 11788583 | SIGNOR-114075 |
| PTP4A3 | dephosphorylation down-regulates ⊣ | KRT8 PSer74 | dephosphorylation up-regulates → | KRT8 | 19115206 | SIGNOR-248340 |
| MAPK8 | phosphorylation up-regulates → | KRT8 PSer74 | phosphorylation up-regulates → | KRT8 | 11781324 | SIGNOR-113645 |
| PRKCD | phosphorylation up-regulates → | KRT8 PSer74 | phosphorylation up-regulates → | KRT8 | 15972820 | SIGNOR-260887 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK1 | phosphorylation → up-regulates | KRT8 | SIGNOR-56054 |
| ERK1/2 | phosphorylation → unknown | KRT8 | SIGNOR-270135 |
| MAPK8 | phosphorylation → up-regulates | KRT8 | SIGNOR-114083 |
| PTPN1 | dephosphorylation → down-regulates activity | KRT8 | SIGNOR-265495 |
| MAPK1 | phosphorylation → unknown | KRT8 | SIGNOR-249411 |
| p38 | phosphorylation → up-regulates | KRT8 | SIGNOR-270125 |
| MAPK11 | phosphorylation → up-regulates | KRT8 | SIGNOR-114063 |
| Gbeta | phosphorylation → unknown | KRT8 | SIGNOR-270003 |
| PPP2CB | dephosphorylation → unknown | KRT8 | SIGNOR-248588 |
| MAPK14 | phosphorylation → up-regulates | KRT8 | SIGNOR-114079 |
| MAPK3 | phosphorylation → unknown | KRT8 | SIGNOR-249468 |
| PTP4A3 | dephosphorylation → down-regulates activity | KRT8 | SIGNOR-248341 |
| MAPK12 | phosphorylation → up-regulates | KRT8 | SIGNOR-114067 |
| MAPK3 | phosphorylation → unknown | KRT8 | SIGNOR-196141 |
| PPP2CA | dephosphorylation → unknown | KRT8 | SIGNOR-248623 |
| MAPK13 | phosphorylation → up-regulates | KRT8 | SIGNOR-114075 |
| PTP4A3 | dephosphorylation → down-regulates activity | KRT8 | SIGNOR-248340 |
| MAPK8 | phosphorylation → up-regulates | KRT8 | SIGNOR-113645 |
| PRKCD | phosphorylation → up-regulates | KRT8 | SIGNOR-260887 |