| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTP4A3 | KRT8 | Ser74 | TVNQSLLsPLVLEVD | dephosphorylation down-regulates activity | 19115206 | SIGNOR-248340 |
| MAPK11 | KRT8 | Ser74 | TVNQSLLsPLVLEVD | phosphorylation up-regulates | 11788583 | SIGNOR-114063 |
| PRKCD | KRT8 | Ser74 | TVNQSLLsPLVLEVD | phosphorylation up-regulates | 15972820 | SIGNOR-260887 |
| MAPK8 | KRT8 | Ser74 | TVNQSLLsPLVLEVD | phosphorylation up-regulates | 11781324 | SIGNOR-113645 |
| MAPK8 | KRT8 | Ser74 | TVNQSLLsPLVLEVD | phosphorylation up-regulates | 11788583 | SIGNOR-114083 |
| MAPK12 | KRT8 | Ser74 | TVNQSLLsPLVLEVD | phosphorylation up-regulates | 11788583 | SIGNOR-114067 |
| MAPK13 | KRT8 | Ser74 | TVNQSLLsPLVLEVD | phosphorylation up-regulates | 11788583 | SIGNOR-114075 |
| MAPK14 | KRT8 | Ser74 | TVNQSLLsPLVLEVD | phosphorylation up-regulates | 11788583 | SIGNOR-114079 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTP4A3 | dephosphorylation down-regulates ⊣ | KRT8 PSer74 | dephosphorylation up-regulates → | KRT8 | 19115206 | SIGNOR-248340 |
| MAPK11 | phosphorylation up-regulates → | KRT8 PSer74 | phosphorylation up-regulates → | KRT8 | 11788583 | SIGNOR-114063 |
| PRKCD | phosphorylation up-regulates → | KRT8 PSer74 | phosphorylation up-regulates → | KRT8 | 15972820 | SIGNOR-260887 |
| MAPK8 | phosphorylation up-regulates → | KRT8 PSer74 | phosphorylation up-regulates → | KRT8 | 11781324 | SIGNOR-113645 |
| MAPK8 | phosphorylation up-regulates → | KRT8 PSer74 | phosphorylation up-regulates → | KRT8 | 11788583 | SIGNOR-114083 |
| MAPK12 | phosphorylation up-regulates → | KRT8 PSer74 | phosphorylation up-regulates → | KRT8 | 11788583 | SIGNOR-114067 |
| MAPK13 | phosphorylation up-regulates → | KRT8 PSer74 | phosphorylation up-regulates → | KRT8 | 11788583 | SIGNOR-114075 |
| MAPK14 | phosphorylation up-regulates → | KRT8 PSer74 | phosphorylation up-regulates → | KRT8 | 11788583 | SIGNOR-114079 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTP4A3 | dephosphorylation → down-regulates activity | KRT8 | SIGNOR-248340 |
| MAPK11 | phosphorylation → up-regulates | KRT8 | SIGNOR-114063 |
| PRKCD | phosphorylation → up-regulates | KRT8 | SIGNOR-260887 |
| MAPK8 | phosphorylation → up-regulates | KRT8 | SIGNOR-113645 |
| MAPK8 | phosphorylation → up-regulates | KRT8 | SIGNOR-114083 |
| MAPK12 | phosphorylation → up-regulates | KRT8 | SIGNOR-114067 |
| MAPK13 | phosphorylation → up-regulates | KRT8 | SIGNOR-114075 |
| MAPK14 | phosphorylation → up-regulates | KRT8 | SIGNOR-114079 |
