| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | KRT8 | Ser432 | SAYGGLTsPGLSYSL | phosphorylation unknown | 16554440 | SIGNOR-249468 |
| MAPK3 | KRT8 | Ser432 | SAYGGLTsPGLSYSL | phosphorylation unknown | 22344252 | SIGNOR-196141 |
| MAPK1 | KRT8 | Ser432 | SAYGGLTsPGLSYSL | phosphorylation unknown | 16554440 | SIGNOR-249411 |
| PPP2CB | KRT8 | Ser432 | SAYGGLTsPGLSYSL | dephosphorylation unknown | 16554440 | SIGNOR-248588 |
| CDK1 | KRT8 | Ser432 | SAYGGLTsPGLSYSL | phosphorylation up-regulates | 9524113 | SIGNOR-56054 |
| PTP4A3 | KRT8 | Ser432 | SAYGGLTsPGLSYSL | dephosphorylation down-regulates activity | 19115206 | SIGNOR-248341 |
| PPP2CA | KRT8 | Ser432 | SAYGGLTsPGLSYSL | dephosphorylation unknown | 16554440 | SIGNOR-248623 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | phosphorylation up-regulates → | KRT8 PSer432 | phosphorylation down-regulates ⊣ | KRT8 | 16554440 | SIGNOR-249468 |
| MAPK3 | phosphorylation up-regulates → | KRT8 PSer432 | phosphorylation down-regulates ⊣ | KRT8 | 22344252 | SIGNOR-196141 |
| MAPK1 | phosphorylation up-regulates → | KRT8 PSer432 | phosphorylation down-regulates ⊣ | KRT8 | 16554440 | SIGNOR-249411 |
| PPP2CB | dephosphorylation down-regulates ⊣ | KRT8 PSer432 | dephosphorylation up-regulates → | KRT8 | 16554440 | SIGNOR-248588 |
| CDK1 | phosphorylation up-regulates → | KRT8 PSer432 | phosphorylation up-regulates → | KRT8 | 9524113 | SIGNOR-56054 |
| PTP4A3 | dephosphorylation down-regulates ⊣ | KRT8 PSer432 | dephosphorylation up-regulates → | KRT8 | 19115206 | SIGNOR-248341 |
| PPP2CA | dephosphorylation down-regulates ⊣ | KRT8 PSer432 | dephosphorylation up-regulates → | KRT8 | 16554440 | SIGNOR-248623 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK3 | phosphorylation → unknown | KRT8 | SIGNOR-249468 |
| MAPK3 | phosphorylation → unknown | KRT8 | SIGNOR-196141 |
| MAPK1 | phosphorylation → unknown | KRT8 | SIGNOR-249411 |
| PPP2CB | dephosphorylation → unknown | KRT8 | SIGNOR-248588 |
| CDK1 | phosphorylation → up-regulates | KRT8 | SIGNOR-56054 |
| PTP4A3 | dephosphorylation → down-regulates activity | KRT8 | SIGNOR-248341 |
| PPP2CA | dephosphorylation → unknown | KRT8 | SIGNOR-248623 |
