| Name | CD5 |
| ID | P06127 |
| Role | substrate |
| Enzymatic Domains |
SRCR 1 35-133 PROSITE-ProRule
SRCR 2 159-268 PROSITE-ProRule
SRCR 3 276-368 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FYN | CD5 | Tyr453 | ASHVDNEySQPPRNS | phosphorylation unknown | 11298344 | SIGNOR-251151 |
| PRKCB | CD5 | Thr434 | MSFHRNHtATVRSHA | phosphorylation unknown | 11123317 | SIGNOR-249073 |
| CSNK2A1 | CD5 | Ser482 | SSMQPDNsSDSDYDL | phosphorylation up-regulates | 9834084 | SIGNOR-62303 |
| LCK | CD5 | Tyr453 | ASHVDNEySQPPRNS | phosphorylation up-regulates activity | 11298344 | SIGNOR-106799 |
| FYN | CD5 | Tyr487 | DNSSDSDyDLHGAQR | phosphorylation unknown | 11298344 | SIGNOR-251152 |
| PRKCA | CD5 | Thr436 | FHRNHTAtVRSHAEN | phosphorylation unknown | 11123317 | SIGNOR-249071 |
| PRKCA | CD5 | Thr436 | FHRNHTAtVRSHAEN | phosphorylation up-regulates | 11123317 | SIGNOR-85179 |
| CSNK2A1 | CD5 | Ser485 | QPDNSSDsDYDLHGA | phosphorylation up-regulates | 9834084 | SIGNOR-62311 |
| PRKCG | CD5 | Thr436 | FHRNHTAtVRSHAEN | phosphorylation up-regulates | 11123317 | SIGNOR-85183 |
| PRKCG | CD5 | Thr434 | MSFHRNHtATVRSHA | phosphorylation unknown | 11123317 | SIGNOR-249072 |
| PRKCB | CD5 | Thr436 | FHRNHTAtVRSHAEN | phosphorylation unknown | 11123317 | SIGNOR-249075 |
| PRKCG | CD5 | Thr436 | FHRNHTAtVRSHAEN | phosphorylation unknown | 11123317 | SIGNOR-249074 |
| LCK | CD5 | Tyr487 | DNSSDSDyDLHGAQR | phosphorylation up-regulates activity | 11298344 | SIGNOR-106803 |
| CSNK2A1 | CD5 | Ser483 | SMQPDNSsDSDYDLH | phosphorylation up-regulates | 9834084 | SIGNOR-62307 |
| PRKCA | CD5 | Thr434 | MSFHRNHtATVRSHA | phosphorylation unknown | 11123317 | SIGNOR-249070 |
| PRKCA | CD5 | Thr434 | MSFHRNHtATVRSHA | phosphorylation up-regulates | 11123317 | SIGNOR-85175 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FYN | phosphorylation up-regulates → | CD5 PTyr453 | phosphorylation down-regulates ⊣ | CD5 | 11298344 | SIGNOR-251151 |
| PRKCB | phosphorylation up-regulates → | CD5 PThr434 | phosphorylation down-regulates ⊣ | CD5 | 11123317 | SIGNOR-249073 |
| CSNK2A1 | phosphorylation up-regulates → | CD5 PSer482 | phosphorylation up-regulates → | CD5 | 9834084 | SIGNOR-62303 |
| LCK | phosphorylation up-regulates → | CD5 PTyr453 | phosphorylation up-regulates → | CD5 | 11298344 | SIGNOR-106799 |
| FYN | phosphorylation up-regulates → | CD5 PTyr487 | phosphorylation down-regulates ⊣ | CD5 | 11298344 | SIGNOR-251152 |
| PRKCA | phosphorylation up-regulates → | CD5 PThr436 | phosphorylation down-regulates ⊣ | CD5 | 11123317 | SIGNOR-249071 |
| PRKCA | phosphorylation up-regulates → | CD5 PThr436 | phosphorylation up-regulates → | CD5 | 11123317 | SIGNOR-85179 |
| CSNK2A1 | phosphorylation up-regulates → | CD5 PSer485 | phosphorylation up-regulates → | CD5 | 9834084 | SIGNOR-62311 |
| PRKCG | phosphorylation up-regulates → | CD5 PThr436 | phosphorylation up-regulates → | CD5 | 11123317 | SIGNOR-85183 |
| PRKCG | phosphorylation up-regulates → | CD5 PThr434 | phosphorylation down-regulates ⊣ | CD5 | 11123317 | SIGNOR-249072 |
| PRKCB | phosphorylation up-regulates → | CD5 PThr436 | phosphorylation down-regulates ⊣ | CD5 | 11123317 | SIGNOR-249075 |
| PRKCG | phosphorylation up-regulates → | CD5 PThr436 | phosphorylation down-regulates ⊣ | CD5 | 11123317 | SIGNOR-249074 |
| LCK | phosphorylation up-regulates → | CD5 PTyr487 | phosphorylation up-regulates → | CD5 | 11298344 | SIGNOR-106803 |
| CSNK2A1 | phosphorylation up-regulates → | CD5 PSer483 | phosphorylation up-regulates → | CD5 | 9834084 | SIGNOR-62307 |
| PRKCA | phosphorylation up-regulates → | CD5 PThr434 | phosphorylation down-regulates ⊣ | CD5 | 11123317 | SIGNOR-249070 |
| PRKCA | phosphorylation up-regulates → | CD5 PThr434 | phosphorylation up-regulates → | CD5 | 11123317 | SIGNOR-85175 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| FYN | phosphorylation → unknown | CD5 | SIGNOR-251151 |
| PRKCB | phosphorylation → unknown | CD5 | SIGNOR-249073 |
| CSNK2A1 | phosphorylation → up-regulates | CD5 | SIGNOR-62303 |
| LCK | phosphorylation → up-regulates activity | CD5 | SIGNOR-106799 |
| FYN | phosphorylation → unknown | CD5 | SIGNOR-251152 |
| PRKCA | phosphorylation → unknown | CD5 | SIGNOR-249071 |
| PRKCA | phosphorylation → up-regulates | CD5 | SIGNOR-85179 |
| CSNK2A1 | phosphorylation → up-regulates | CD5 | SIGNOR-62311 |
| PRKCG | phosphorylation → up-regulates | CD5 | SIGNOR-85183 |
| PRKCG | phosphorylation → unknown | CD5 | SIGNOR-249072 |
| PRKCB | phosphorylation → unknown | CD5 | SIGNOR-249075 |
| PRKCG | phosphorylation → unknown | CD5 | SIGNOR-249074 |
| LCK | phosphorylation → up-regulates activity | CD5 | SIGNOR-106803 |
| CSNK2A1 | phosphorylation → up-regulates | CD5 | SIGNOR-62307 |
| PRKCA | phosphorylation → unknown | CD5 | SIGNOR-249070 |
| PRKCA | phosphorylation → up-regulates | CD5 | SIGNOR-85175 |