| Name | LCK |
| ID | P06239 |
| Role | kinase |
| Enzymatic Domains |
SH3 61-121 PROSITE-ProRule
SH2 127-224 PROSITE-ProRule
Protein kinase 245-498 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LCK | ACP1 | Tyr132 | QLIIEDPyYGNDSDF | phosphorylation up-regulates activity | 9038134 | SIGNOR-251366 |
| LCK | ADAM15 | Tyr735 | LKGPTCQyRAAQSGP | phosphorylation up-regulates | 11741929 | SIGNOR-112935 |
| LCK | ERK1/2 | – | phosphorylation up-regulates | 17998336 | SIGNOR-269921 | |
| LCK | PRDX1 | Tyr194 | DVQKSKEyFSKQK | phosphorylation down-regulates activity | 20178744 | SIGNOR-276277 |
| LCK | NFKBIA | Tyr42 | DSMKDEEyEQMVKEL | phosphorylation down-regulates quantity by destabilization | 14534291 | SIGNOR-249374 |
| LCK | ZAP70 | Tyr319 | TSVYESPySDPEELK | phosphorylation up-regulates activity | 10037717 | SIGNOR-251393 |
| LCK | CD3E | Tyr188 | PPVPNPDyEPIRKGQ | phosphorylation up-regulates activity | 11855827 | SIGNOR-251368 |
| LCK | LAT | Tyr220 | SLDGSREyVNVSQEL | phosphorylation up-regulates | 16938345 | SIGNOR-149186 |
| LCK | EZR | Tyr146 | KEVHKSGyLSSERLI | phosphorylation unknown | 12560083 | SIGNOR-251374 |
| LCK | SSBP3 | Tyr23 | AREKLALyVYEYLLH | phosphorylation up-regulates activity | 18080319 | SIGNOR-273649 |
| LCK | ZAP70 | Tyr492 | ALGADDSyYTARSAG | phosphorylation up-regulates activity | 7642520 | SIGNOR-30429 |
| LCK | CD247 | – | phosphorylation up-regulates | 8626561 | SIGNOR-41361 | |
| LCK | IL2RB | Tyr418 | LSGEDDAyCTFPSRD | phosphorylation unknown | 10214954 | SIGNOR-251378 |
| LCK | ADAM15 | Tyr715 | LVMLGASyWYRARLH | phosphorylation up-regulates | 11741929 | SIGNOR-112931 |
| LCK | SH2D2A | Tyr305 | GEAPSNIyVEVEDEG | phosphorylation up-regulates activity | 18541536 | SIGNOR-262890 |
| LCK | CD28 | Tyr191 | SRLLHSDyMNMTPRR | phosphorylation up-regulates | 22936936 | SIGNOR-198755 |
| LCK | SH2D2A | Tyr290 | PDEPIAFyAMGRGSP | phosphorylation up-regulates activity | 18541536 | SIGNOR-262889 |
| LCK | MAPK14 | Tyr323 | DEPVADPyDQSFESR | phosphorylation up-regulates activity | 15735648 | SIGNOR-276029 |
| LCK | SIGLEC10 | Tyr597 | RHSTILDyINVVPTA | phosphorylation up-regulates | 11733002 | SIGNOR-112491 |
| LCK | ZAP70 | Tyr493 | LGADDSYyTARSAGK | phosphorylation up-regulates activity | 7961936 | SIGNOR-251395 |
| LCK | TCR | – | phosphorylation up-regulates activity | 2470098 | SIGNOR-259932 | |
| LCK | CD3G | – | phosphorylation up-regulates activity | 2470098 | SIGNOR-259931 | |
| LCK | PTPN6 | Tyr536 | QKGQESEyGNITYPP | phosphorylation up-regulates activity | 8114715 | SIGNOR-251387 |
| LCK | PTEN | Tyr240 | RREDKFMyFEFPQPL | phosphorylation up-regulates activity | 11948419 | SIGNOR-275984 |
| LCK | CD5 | Tyr487 | DNSSDSDyDLHGAQR | phosphorylation up-regulates activity | 11298344 | SIGNOR-106803 |
| LCK | STAT3 | – | phosphorylation up-regulates activity | 10617281 | SIGNOR-279201 | |
| LCK | PECAM1 | Tyr713 | KKDTETVySEVRKAV | phosphorylation up-regulates activity | 9624175 | SIGNOR-262742 |
| LCK | CTLA4 | Tyr201 | SPLTTGVyVKMPPTE | phosphorylation up-regulates quantity by stabilization | 9973379 | SIGNOR-251370 |
| LCK | PRKCD | Tyr514 | TFCGTPDyIAPEILQ | phosphorylation up-regulates activity | 11381116 | SIGNOR-251386 |
| LCK | LAX1 | Tyr268 | SSQISNDyVNMTGLD | phosphorylation up-regulates activity | 12359715 | SIGNOR-273526 |
| LCK | SSBP3 | Tyr25 | EKLALYVyEYLLHVG | phosphorylation up-regulates activity | 18080319 | SIGNOR-273648 |
| LCK | CD3 | – | phosphorylation up-regulates activity | 8626561 | SIGNOR-252305 | |
| LCK | CTLA4 | Tyr218 | CEKQFQPyFIPIN | phosphorylation unknown | 9973379 | SIGNOR-251371 |
| LCK | SIGLEC10 | Tyr667 | ESQEELHyATLNFPG | phosphorylation up-regulates | 11733002 | SIGNOR-112495 |
| LCK | DOK1 | – | phosphorylation up-regulates activity | 10799545 | SIGNOR-251373 | |
| LCK | ZAP70 | Tyr319 | TSVYESPySDPEELK | phosphorylation up-regulates activity | 10202147 | SIGNOR-273948 |
| LCK | VAV1 | Tyr142 | SVGDEDIySGLSDQI | phosphorylation unknown | 10669745 | SIGNOR-251389 |
| LCK | CD3D | – | phosphorylation up-regulates activity | 2470098 | SIGNOR-259929 | |
| LCK | SH2D2A | Tyr280 | PKPSNPIyNEPDEPI | phosphorylation up-regulates activity | 18541536 | SIGNOR-262888 |
| LCK | PTPN6 | Tyr564 | SKHKEDVyENLHTKN | phosphorylation up-regulates | 8114715 | SIGNOR-36121 |
| LCK | CD3G | – | phosphorylation up-regulates activity | 2470098 | SIGNOR-259928 | |
| LCK | VAV1 | Tyr174 | EAEGDEIyEDLMRSE | phosphorylation unknown | 10669745 | SIGNOR-251391 |
| LCK | PIK3R1 | Tyr688 | FAEPYNLySSLKELV | phosphorylation down-regulates activity | 9461588 | SIGNOR-251383 |
| LCK | STAT5B | – | phosphorylation up-regulates activity | 16446405 | SIGNOR-279056 | |
| LCK | ESR1 | Tyr537 | CKNVVPLyDLLLEML | phosphorylation up-regulates | 10571988 | SIGNOR-72373 |
| LCK | IL2RB | Tyr536 | LPLNTDAyLSLQELQ | phosphorylation unknown | 10214954 | SIGNOR-251379 |
| LCK | PI3K | Tyr688 | FAEPYNLySSLKELV | phosphorylation down-regulates activity | 9461588 | SIGNOR-252699 |
| LCK | VAV1 | Tyr160 | VEEDEDLyDCVENEE | phosphorylation unknown | 10669745 | SIGNOR-251390 |
| LCK | PRKCD | Tyr334 | MQDNSGTyGKIWEGS | phosphorylation up-regulates activity | 11381116 | SIGNOR-251385 |
| LCK | MED28 | Tyr64 | ASLVSQDyVNGTDQE | phosphorylation up-regulates | 16899217 | SIGNOR-148704 |
| LCK | IL2RB | Tyr381 | EIEACQVyFTYDPYS | phosphorylation unknown | 10214954 | SIGNOR-251375 |
| LCK | PLCG2 | Tyr753 | ERDINSLyDVSRMYV | phosphorylation up-regulates | 12181444 | SIGNOR-91473 |
| LCK | SHC1 | Tyr427 | ELFDDPSyVNVQNLD | phosphorylation up-regulates activity | 9710204 | SIGNOR-251388 |
| LCK | ITK | Tyr512 | RFVLDDQyTSSTGTK | phosphorylation up-regulates | 9312162 | SIGNOR-251380 |
| LCK | CCDC50 | Tyr217 | MAEEKKAyKKAKERE | phosphorylation down-regulates activity | 19059208 | SIGNOR-262853 |
| LCK | CD28 | Tyr191 | SRLLHSDyMNMTPRR | phosphorylation up-regulates | 8992971 | SIGNOR-45524 |
| LCK | CD3E | Tyr199 | RKGQRDLySGLNQRR | phosphorylation up-regulates activity | 11855827 | SIGNOR-251369 |
| LCK | DEF6 | Tyr210 | SMAIHEVyQELIQDV | phosphorylation up-regulates activity | 12923183 | SIGNOR-251372 |
| LCK | CD5 | Tyr453 | ASHVDNEySQPPRNS | phosphorylation up-regulates activity | 11298344 | SIGNOR-106799 |
| LCK | TBK1 | Tyr354 | SSNQELIyEGRRLVL | phosphorylation down-regulates activity | 28618271 | SIGNOR-276724 |
| LCK | DEF6 | Tyr133 | NFLSEDKyPLIMVPD | phosphorylation up-regulates activity | 18976935 | SIGNOR-253367 |
| LCK | CHN2 | Tyr153 | KMTTNPIyEHIGYAT | phosphorylation down-regulates activity | 19201754 | SIGNOR-276240 |
| LCK | IL2RB | Tyr384 | ACQVYFTyDPYSEED | phosphorylation unknown | 10214954 | SIGNOR-251376 |
| LCK | MUC1 | Tyr1229 | SSTDRSPyEKVSAGN | phosphorylation up-regulates activity | 14766232 | SIGNOR-249358 |
| LCK | SH2B3 | Tyr273 | LEMPDNLyTFVLKVK | phosphorylation up-regulates | 9169414 | SIGNOR-48850 |
| LCK | DAPP1 | Tyr139 | KVEEPSIyESVRVHT | phosphorylation up-regulates activity | 10880360 | SIGNOR-249373 |
| LCK | SIGLEC10 | Tyr691 | PKGTQADyAEVKFQ | phosphorylation unknown | 11733002 | SIGNOR-112499 |
| LCK | TBK1 | Tyr394 | LNTIGLIyEKISLPK | phosphorylation down-regulates activity | 28618271 | SIGNOR-276723 |
| LCK | ZAP70 | Tyr474 | VLLVNRHyAKISDFG | phosphorylation up-regulates activity | 9685404 | SIGNOR-249375 |
| LCK | ESR1 | Tyr537 | CKNVVPLyDLLLEML | phosphorylation up-regulates | 9500442 | SIGNOR-55853 |
| LCK | LCP2 | Tyr426 | NEEWYVSyITRPEAE | phosphorylation unknown | 8702662 | SIGNOR-251382 |
| LCK | LCK | Tyr394 | RLIEDNEyTAREGAK | phosphorylation up-regulates activity | 2250907 | SIGNOR-81372 |
| LCK | ACP1 | Tyr133 | LIIEDPYyGNDSDFE | phosphorylation up-regulates activity | 9038134 | SIGNOR-251367 |
| LCK | LAX1 | Tyr193 | SSEDSHDyVNVPTAE | phosphorylation up-regulates activity | 12359715 | SIGNOR-273525 |
| LCK | CCDC50 | Tyr279 | TDGEDADyTHFTNQQ | phosphorylation down-regulates activity | 19059208 | SIGNOR-262854 |
| LCK | CD33 | Tyr340 | EMDEELHyASLNFHG | phosphorylation up-regulates | 10887109 | SIGNOR-78960 |
| LCK | PTEN | Tyr315 | RADNDKEyLVLTLTK | phosphorylation up-regulates activity | 11948419 | SIGNOR-275983 |
| LCK | PTEN | Tyr315 | RADNDKEyLVLTLTK | phosphorylation up-regulates | 11948419 | SIGNOR-116499 |
| LCK | CCDC50 | Tyr304 | SSHKGFHyKH | phosphorylation down-regulates activity | 19059208 | SIGNOR-262855 |
| LCK | MAPK3 | Tyr204 | HTGFLTEyVATRWYR | phosphorylation up-regulates | 17998336 | SIGNOR-159168 |
| LCK | LCP2 | Tyr423 | NSLNEEWyVSYITRP | phosphorylation unknown | 8702662 | SIGNOR-251381 |
| LCK | DEF6 | Tyr144 | MVPDEVEyLLKKVLS | phosphorylation up-regulates activity | 18976935 | SIGNOR-253368 |
| LCK | ZAP70 | Tyr69 | ERQLNGTyAIAGGKA | phosphorylation unknown | 7961936 | SIGNOR-251396 |
| LCK | LAT | Tyr200 | SMESIDDyVNVPESG | phosphorylation up-regulates | 16938345 | SIGNOR-149182 |
| LCK | LAX1 | Tyr294 | AFQCCRDyENVPAAD | phosphorylation up-regulates activity | 12359715 | SIGNOR-273527 |
| LCK | ZAP70 | Tyr178 | EEAERKLySGAQTDG | phosphorylation unknown | 7961936 | SIGNOR-251392 |
| LCK | LAX1 | Tyr373 | SNEDSSDyENVLTAK | phosphorylation up-regulates activity | 12359715 | SIGNOR-273528 |
| LCK | ZAP70 | Tyr493 | LGADDSYyTARSAGK | phosphorylation up-regulates activity | 8756661 | SIGNOR-226628 |
| LCK | IL2RB | Tyr387 | VYFTYDPySEEDPDE | phosphorylation unknown | 10214954 | SIGNOR-251377 |
| LCK | PRKCD | Tyr313 | SSEPVGIyQGFEKKT | phosphorylation up-regulates activity | 11381116 | SIGNOR-251384 |
| LCK | PLCG2 | Tyr759 | LYDVSRMyVDPSEIN | phosphorylation up-regulates | 12181444 | SIGNOR-91477 |
| LCK | PRKCQ | Tyr90 | SETTVELySLAERCR | phosphorylation unknown | 10652356 | SIGNOR-74574 |
| LCK | PRDX2 | Tyr193 | NVDDSKEyFSKHN | phosphorylation down-regulates activity | 20178744 | SIGNOR-276279 |
| LCK | Gbeta | – | phosphorylation up-regulates | 17998336 | SIGNOR-269899 | |
| LCK | MUC1 | Tyr1229 | SSTDRSPyEKVSAGN | phosphorylation up-regulates activity | 14766232 | SIGNOR-247058 |
| LCK | CD3E | – | phosphorylation up-regulates activity | 2470098 | SIGNOR-259930 | |
| LCK | FOXP3 | Tyr342 | NMRPPFTyATLIRWA | phosphorylation down-regulates | 24155921 | SIGNOR-203089 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LCK | phosphorylation up-regulates → | ACP1 PTyr132 | phosphorylation up-regulates → | ACP1 | 9038134 | SIGNOR-251366 |
| LCK | phosphorylation up-regulates → | ADAM15 PTyr735 | phosphorylation up-regulates → | ADAM15 | 11741929 | SIGNOR-112935 |
| LCK | phosphorylation up-regulates → | PRDX1 PTyr194 | phosphorylation down-regulates ⊣ | PRDX1 | 20178744 | SIGNOR-276277 |
| LCK | phosphorylation up-regulates → | NFKBIA PTyr42 | phosphorylation down-regulates ⊣ | NFKBIA | 14534291 | SIGNOR-249374 |
| LCK | phosphorylation up-regulates → | ZAP70 PTyr319 | phosphorylation up-regulates → | ZAP70 | 10037717 | SIGNOR-251393 |
| LCK | phosphorylation up-regulates → | CD3E PTyr188 | phosphorylation up-regulates → | CD3E | 11855827 | SIGNOR-251368 |
| LCK | phosphorylation up-regulates → | LAT PTyr220 | phosphorylation up-regulates → | LAT | 16938345 | SIGNOR-149186 |
| LCK | phosphorylation up-regulates → | EZR PTyr146 | phosphorylation down-regulates ⊣ | EZR | 12560083 | SIGNOR-251374 |
| LCK | phosphorylation up-regulates → | SSBP3 PTyr23 | phosphorylation up-regulates → | SSBP3 | 18080319 | SIGNOR-273649 |
| LCK | phosphorylation up-regulates → | ZAP70 PTyr492 | phosphorylation up-regulates → | ZAP70 | 7642520 | SIGNOR-30429 |
| LCK | phosphorylation up-regulates → | IL2RB PTyr418 | phosphorylation down-regulates ⊣ | IL2RB | 10214954 | SIGNOR-251378 |
| LCK | phosphorylation up-regulates → | ADAM15 PTyr715 | phosphorylation up-regulates → | ADAM15 | 11741929 | SIGNOR-112931 |
| LCK | phosphorylation up-regulates → | SH2D2A PTyr305 | phosphorylation up-regulates → | SH2D2A | 18541536 | SIGNOR-262890 |
| LCK | phosphorylation up-regulates → | CD28 PTyr191 | phosphorylation up-regulates → | CD28 | 22936936 | SIGNOR-198755 |
| LCK | phosphorylation up-regulates → | SH2D2A PTyr290 | phosphorylation up-regulates → | SH2D2A | 18541536 | SIGNOR-262889 |
| LCK | phosphorylation up-regulates → | MAPK14 PTyr323 | phosphorylation up-regulates → | MAPK14 | 15735648 | SIGNOR-276029 |
| LCK | phosphorylation up-regulates → | SIGLEC10 PTyr597 | phosphorylation up-regulates → | SIGLEC10 | 11733002 | SIGNOR-112491 |
| LCK | phosphorylation up-regulates → | ZAP70 PTyr493 | phosphorylation up-regulates → | ZAP70 | 7961936 | SIGNOR-251395 |
| LCK | phosphorylation up-regulates → | PTPN6 PTyr536 | phosphorylation up-regulates → | PTPN6 | 8114715 | SIGNOR-251387 |
| LCK | phosphorylation up-regulates → | PTEN PTyr240 | phosphorylation up-regulates → | PTEN | 11948419 | SIGNOR-275984 |
| LCK | phosphorylation up-regulates → | CD5 PTyr487 | phosphorylation up-regulates → | CD5 | 11298344 | SIGNOR-106803 |
| LCK | phosphorylation up-regulates → | PECAM1 PTyr713 | phosphorylation up-regulates → | PECAM1 | 9624175 | SIGNOR-262742 |
| LCK | phosphorylation up-regulates → | CTLA4 PTyr201 | phosphorylation up-regulates → | CTLA4 | 9973379 | SIGNOR-251370 |
| LCK | phosphorylation up-regulates → | PRKCD PTyr514 | phosphorylation up-regulates → | PRKCD | 11381116 | SIGNOR-251386 |
| LCK | phosphorylation up-regulates → | LAX1 PTyr268 | phosphorylation up-regulates → | LAX1 | 12359715 | SIGNOR-273526 |
| LCK | phosphorylation up-regulates → | SSBP3 PTyr25 | phosphorylation up-regulates → | SSBP3 | 18080319 | SIGNOR-273648 |
| LCK | phosphorylation up-regulates → | CTLA4 PTyr218 | phosphorylation down-regulates ⊣ | CTLA4 | 9973379 | SIGNOR-251371 |
| LCK | phosphorylation up-regulates → | SIGLEC10 PTyr667 | phosphorylation up-regulates → | SIGLEC10 | 11733002 | SIGNOR-112495 |
| LCK | phosphorylation up-regulates → | ZAP70 PTyr319 | phosphorylation up-regulates → | ZAP70 | 10202147 | SIGNOR-273948 |
| LCK | phosphorylation up-regulates → | VAV1 PTyr142 | phosphorylation down-regulates ⊣ | VAV1 | 10669745 | SIGNOR-251389 |
| LCK | phosphorylation up-regulates → | SH2D2A PTyr280 | phosphorylation up-regulates → | SH2D2A | 18541536 | SIGNOR-262888 |
| LCK | phosphorylation up-regulates → | PTPN6 PTyr564 | phosphorylation up-regulates → | PTPN6 | 8114715 | SIGNOR-36121 |
| LCK | phosphorylation up-regulates → | VAV1 PTyr174 | phosphorylation down-regulates ⊣ | VAV1 | 10669745 | SIGNOR-251391 |
| LCK | phosphorylation up-regulates → | PIK3R1 PTyr688 | phosphorylation down-regulates ⊣ | PIK3R1 | 9461588 | SIGNOR-251383 |
| LCK | phosphorylation up-regulates → | ESR1 PTyr537 | phosphorylation up-regulates → | ESR1 | 10571988 | SIGNOR-72373 |
| LCK | phosphorylation up-regulates → | IL2RB PTyr536 | phosphorylation down-regulates ⊣ | IL2RB | 10214954 | SIGNOR-251379 |
| LCK | phosphorylation up-regulates → | PI3K PTyr688 | phosphorylation down-regulates ⊣ | PI3K | 9461588 | SIGNOR-252699 |
| LCK | phosphorylation up-regulates → | VAV1 PTyr160 | phosphorylation down-regulates ⊣ | VAV1 | 10669745 | SIGNOR-251390 |
| LCK | phosphorylation up-regulates → | PRKCD PTyr334 | phosphorylation up-regulates → | PRKCD | 11381116 | SIGNOR-251385 |
| LCK | phosphorylation up-regulates → | MED28 PTyr64 | phosphorylation up-regulates → | MED28 | 16899217 | SIGNOR-148704 |
| LCK | phosphorylation up-regulates → | IL2RB PTyr381 | phosphorylation down-regulates ⊣ | IL2RB | 10214954 | SIGNOR-251375 |
| LCK | phosphorylation up-regulates → | PLCG2 PTyr753 | phosphorylation up-regulates → | PLCG2 | 12181444 | SIGNOR-91473 |
| LCK | phosphorylation up-regulates → | SHC1 PTyr427 | phosphorylation up-regulates → | SHC1 | 9710204 | SIGNOR-251388 |
| LCK | phosphorylation up-regulates → | ITK PTyr512 | phosphorylation up-regulates → | ITK | 9312162 | SIGNOR-251380 |
| LCK | phosphorylation up-regulates → | CCDC50 PTyr217 | phosphorylation down-regulates ⊣ | CCDC50 | 19059208 | SIGNOR-262853 |
| LCK | phosphorylation up-regulates → | CD28 PTyr191 | phosphorylation up-regulates → | CD28 | 8992971 | SIGNOR-45524 |
| LCK | phosphorylation up-regulates → | CD3E PTyr199 | phosphorylation up-regulates → | CD3E | 11855827 | SIGNOR-251369 |
| LCK | phosphorylation up-regulates → | DEF6 PTyr210 | phosphorylation up-regulates → | DEF6 | 12923183 | SIGNOR-251372 |
| LCK | phosphorylation up-regulates → | CD5 PTyr453 | phosphorylation up-regulates → | CD5 | 11298344 | SIGNOR-106799 |
| LCK | phosphorylation up-regulates → | TBK1 PTyr354 | phosphorylation down-regulates ⊣ | TBK1 | 28618271 | SIGNOR-276724 |
| LCK | phosphorylation up-regulates → | DEF6 PTyr133 | phosphorylation up-regulates → | DEF6 | 18976935 | SIGNOR-253367 |
| LCK | phosphorylation up-regulates → | CHN2 PTyr153 | phosphorylation down-regulates ⊣ | CHN2 | 19201754 | SIGNOR-276240 |
| LCK | phosphorylation up-regulates → | IL2RB PTyr384 | phosphorylation down-regulates ⊣ | IL2RB | 10214954 | SIGNOR-251376 |
| LCK | phosphorylation up-regulates → | MUC1 PTyr1229 | phosphorylation up-regulates → | MUC1 | 14766232 | SIGNOR-249358 |
| LCK | phosphorylation up-regulates → | SH2B3 PTyr273 | phosphorylation up-regulates → | SH2B3 | 9169414 | SIGNOR-48850 |
| LCK | phosphorylation up-regulates → | DAPP1 PTyr139 | phosphorylation up-regulates → | DAPP1 | 10880360 | SIGNOR-249373 |
| LCK | phosphorylation up-regulates → | SIGLEC10 PTyr691 | phosphorylation down-regulates ⊣ | SIGLEC10 | 11733002 | SIGNOR-112499 |
| LCK | phosphorylation up-regulates → | TBK1 PTyr394 | phosphorylation down-regulates ⊣ | TBK1 | 28618271 | SIGNOR-276723 |
| LCK | phosphorylation up-regulates → | ZAP70 PTyr474 | phosphorylation up-regulates → | ZAP70 | 9685404 | SIGNOR-249375 |
| LCK | phosphorylation up-regulates → | ESR1 PTyr537 | phosphorylation up-regulates → | ESR1 | 9500442 | SIGNOR-55853 |
| LCK | phosphorylation up-regulates → | LCP2 PTyr426 | phosphorylation down-regulates ⊣ | LCP2 | 8702662 | SIGNOR-251382 |
| LCK | phosphorylation up-regulates → | LCK PTyr394 | phosphorylation up-regulates → | LCK | 2250907 | SIGNOR-81372 |
| LCK | phosphorylation up-regulates → | ACP1 PTyr133 | phosphorylation up-regulates → | ACP1 | 9038134 | SIGNOR-251367 |
| LCK | phosphorylation up-regulates → | LAX1 PTyr193 | phosphorylation up-regulates → | LAX1 | 12359715 | SIGNOR-273525 |
| LCK | phosphorylation up-regulates → | CCDC50 PTyr279 | phosphorylation down-regulates ⊣ | CCDC50 | 19059208 | SIGNOR-262854 |
| LCK | phosphorylation up-regulates → | CD33 PTyr340 | phosphorylation up-regulates → | CD33 | 10887109 | SIGNOR-78960 |
| LCK | phosphorylation up-regulates → | PTEN PTyr315 | phosphorylation up-regulates → | PTEN | 11948419 | SIGNOR-275983 |
| LCK | phosphorylation up-regulates → | PTEN PTyr315 | phosphorylation up-regulates → | PTEN | 11948419 | SIGNOR-116499 |
| LCK | phosphorylation up-regulates → | CCDC50 PTyr304 | phosphorylation down-regulates ⊣ | CCDC50 | 19059208 | SIGNOR-262855 |
| LCK | phosphorylation up-regulates → | MAPK3 PTyr204 | phosphorylation up-regulates → | MAPK3 | 17998336 | SIGNOR-159168 |
| LCK | phosphorylation up-regulates → | LCP2 PTyr423 | phosphorylation down-regulates ⊣ | LCP2 | 8702662 | SIGNOR-251381 |
| LCK | phosphorylation up-regulates → | DEF6 PTyr144 | phosphorylation up-regulates → | DEF6 | 18976935 | SIGNOR-253368 |
| LCK | phosphorylation up-regulates → | ZAP70 PTyr69 | phosphorylation down-regulates ⊣ | ZAP70 | 7961936 | SIGNOR-251396 |
| LCK | phosphorylation up-regulates → | LAT PTyr200 | phosphorylation up-regulates → | LAT | 16938345 | SIGNOR-149182 |
| LCK | phosphorylation up-regulates → | LAX1 PTyr294 | phosphorylation up-regulates → | LAX1 | 12359715 | SIGNOR-273527 |
| LCK | phosphorylation up-regulates → | ZAP70 PTyr178 | phosphorylation down-regulates ⊣ | ZAP70 | 7961936 | SIGNOR-251392 |
| LCK | phosphorylation up-regulates → | LAX1 PTyr373 | phosphorylation up-regulates → | LAX1 | 12359715 | SIGNOR-273528 |
| LCK | phosphorylation up-regulates → | ZAP70 PTyr493 | phosphorylation up-regulates → | ZAP70 | 8756661 | SIGNOR-226628 |
| LCK | phosphorylation up-regulates → | IL2RB PTyr387 | phosphorylation down-regulates ⊣ | IL2RB | 10214954 | SIGNOR-251377 |
| LCK | phosphorylation up-regulates → | PRKCD PTyr313 | phosphorylation up-regulates → | PRKCD | 11381116 | SIGNOR-251384 |
| LCK | phosphorylation up-regulates → | PLCG2 PTyr759 | phosphorylation up-regulates → | PLCG2 | 12181444 | SIGNOR-91477 |
| LCK | phosphorylation up-regulates → | PRKCQ PTyr90 | phosphorylation down-regulates ⊣ | PRKCQ | 10652356 | SIGNOR-74574 |
| LCK | phosphorylation up-regulates → | PRDX2 PTyr193 | phosphorylation down-regulates ⊣ | PRDX2 | 20178744 | SIGNOR-276279 |
| LCK | phosphorylation up-regulates → | MUC1 PTyr1229 | phosphorylation up-regulates → | MUC1 | 14766232 | SIGNOR-247058 |
| LCK | phosphorylation up-regulates → | FOXP3 PTyr342 | phosphorylation down-regulates ⊣ | FOXP3 | 24155921 | SIGNOR-203089 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| LCK | phosphorylation → up-regulates activity | ACP1 | SIGNOR-251366 |
| LCK | phosphorylation → up-regulates | ADAM15 | SIGNOR-112935 |
| LCK | phosphorylation → up-regulates | ERK1/2 | SIGNOR-269921 |
| LCK | phosphorylation → down-regulates activity | PRDX1 | SIGNOR-276277 |
| LCK | phosphorylation down-regulates quantity by destabilization | NFKBIA | SIGNOR-249374 |
| LCK | phosphorylation → up-regulates activity | ZAP70 | SIGNOR-251393 |
| LCK | phosphorylation → up-regulates activity | CD3E | SIGNOR-251368 |
| LCK | phosphorylation → up-regulates | LAT | SIGNOR-149186 |
| LCK | phosphorylation → unknown | EZR | SIGNOR-251374 |
| LCK | phosphorylation → up-regulates activity | SSBP3 | SIGNOR-273649 |
| LCK | phosphorylation → up-regulates activity | ZAP70 | SIGNOR-30429 |
| LCK | phosphorylation → up-regulates | CD247 | SIGNOR-41361 |
| LCK | phosphorylation → unknown | IL2RB | SIGNOR-251378 |
| LCK | phosphorylation → up-regulates | ADAM15 | SIGNOR-112931 |
| LCK | phosphorylation → up-regulates activity | SH2D2A | SIGNOR-262890 |
| LCK | phosphorylation → up-regulates | CD28 | SIGNOR-198755 |
| LCK | phosphorylation → up-regulates activity | SH2D2A | SIGNOR-262889 |
| LCK | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-276029 |
| LCK | phosphorylation → up-regulates | SIGLEC10 | SIGNOR-112491 |
| LCK | phosphorylation → up-regulates activity | ZAP70 | SIGNOR-251395 |
| LCK | phosphorylation → up-regulates activity | TCR | SIGNOR-259932 |
| LCK | phosphorylation → up-regulates activity | CD3G | SIGNOR-259931 |
| LCK | phosphorylation → up-regulates activity | PTPN6 | SIGNOR-251387 |
| LCK | phosphorylation → up-regulates activity | PTEN | SIGNOR-275984 |
| LCK | phosphorylation → up-regulates activity | CD5 | SIGNOR-106803 |
| LCK | phosphorylation → up-regulates activity | STAT3 | SIGNOR-279201 |
| LCK | phosphorylation → up-regulates activity | PECAM1 | SIGNOR-262742 |
| LCK | phosphorylation → up-regulates quantity by stabilization | CTLA4 | SIGNOR-251370 |
| LCK | phosphorylation → up-regulates activity | PRKCD | SIGNOR-251386 |
| LCK | phosphorylation → up-regulates activity | LAX1 | SIGNOR-273526 |
| LCK | phosphorylation → up-regulates activity | SSBP3 | SIGNOR-273648 |
| LCK | phosphorylation → up-regulates activity | CD3 | SIGNOR-252305 |
| LCK | phosphorylation → unknown | CTLA4 | SIGNOR-251371 |
| LCK | phosphorylation → up-regulates | SIGLEC10 | SIGNOR-112495 |
| LCK | phosphorylation → up-regulates activity | DOK1 | SIGNOR-251373 |
| LCK | phosphorylation → up-regulates activity | ZAP70 | SIGNOR-273948 |
| LCK | phosphorylation → unknown | VAV1 | SIGNOR-251389 |
| LCK | phosphorylation → up-regulates activity | CD3D | SIGNOR-259929 |
| LCK | phosphorylation → up-regulates activity | SH2D2A | SIGNOR-262888 |
| LCK | phosphorylation → up-regulates | PTPN6 | SIGNOR-36121 |
| LCK | phosphorylation → up-regulates activity | CD3G | SIGNOR-259928 |
| LCK | phosphorylation → unknown | VAV1 | SIGNOR-251391 |
| LCK | phosphorylation → down-regulates activity | PIK3R1 | SIGNOR-251383 |
| LCK | phosphorylation → up-regulates activity | STAT5B | SIGNOR-279056 |
| LCK | phosphorylation → up-regulates | ESR1 | SIGNOR-72373 |
| LCK | phosphorylation → unknown | IL2RB | SIGNOR-251379 |
| LCK | phosphorylation → down-regulates activity | PI3K | SIGNOR-252699 |
| LCK | phosphorylation → unknown | VAV1 | SIGNOR-251390 |
| LCK | phosphorylation → up-regulates activity | PRKCD | SIGNOR-251385 |
| LCK | phosphorylation → up-regulates | MED28 | SIGNOR-148704 |
| LCK | phosphorylation → unknown | IL2RB | SIGNOR-251375 |
| LCK | phosphorylation → up-regulates | PLCG2 | SIGNOR-91473 |
| LCK | phosphorylation → up-regulates activity | SHC1 | SIGNOR-251388 |
| LCK | phosphorylation → up-regulates | ITK | SIGNOR-251380 |
| LCK | phosphorylation → down-regulates activity | CCDC50 | SIGNOR-262853 |
| LCK | phosphorylation → up-regulates | CD28 | SIGNOR-45524 |
| LCK | phosphorylation → up-regulates activity | CD3E | SIGNOR-251369 |
| LCK | phosphorylation → up-regulates activity | DEF6 | SIGNOR-251372 |
| LCK | phosphorylation → up-regulates activity | CD5 | SIGNOR-106799 |
| LCK | phosphorylation → down-regulates activity | TBK1 | SIGNOR-276724 |
| LCK | phosphorylation → up-regulates activity | DEF6 | SIGNOR-253367 |
| LCK | phosphorylation → down-regulates activity | CHN2 | SIGNOR-276240 |
| LCK | phosphorylation → unknown | IL2RB | SIGNOR-251376 |
| LCK | phosphorylation → up-regulates activity | MUC1 | SIGNOR-249358 |
| LCK | phosphorylation → up-regulates | SH2B3 | SIGNOR-48850 |
| LCK | phosphorylation → up-regulates activity | DAPP1 | SIGNOR-249373 |
| LCK | phosphorylation → unknown | SIGLEC10 | SIGNOR-112499 |
| LCK | phosphorylation → down-regulates activity | TBK1 | SIGNOR-276723 |
| LCK | phosphorylation → up-regulates activity | ZAP70 | SIGNOR-249375 |
| LCK | phosphorylation → up-regulates | ESR1 | SIGNOR-55853 |
| LCK | phosphorylation → unknown | LCP2 | SIGNOR-251382 |
| LCK | phosphorylation → up-regulates activity | LCK | SIGNOR-81372 |
| LCK | phosphorylation → up-regulates activity | ACP1 | SIGNOR-251367 |
| LCK | phosphorylation → up-regulates activity | LAX1 | SIGNOR-273525 |
| LCK | phosphorylation → down-regulates activity | CCDC50 | SIGNOR-262854 |
| LCK | phosphorylation → up-regulates | CD33 | SIGNOR-78960 |
| LCK | phosphorylation → up-regulates activity | PTEN | SIGNOR-275983 |
| LCK | phosphorylation → up-regulates | PTEN | SIGNOR-116499 |
| LCK | phosphorylation → down-regulates activity | CCDC50 | SIGNOR-262855 |
| LCK | phosphorylation → up-regulates | MAPK3 | SIGNOR-159168 |
| LCK | phosphorylation → unknown | LCP2 | SIGNOR-251381 |
| LCK | phosphorylation → up-regulates activity | DEF6 | SIGNOR-253368 |
| LCK | phosphorylation → unknown | ZAP70 | SIGNOR-251396 |
| LCK | phosphorylation → up-regulates | LAT | SIGNOR-149182 |
| LCK | phosphorylation → up-regulates activity | LAX1 | SIGNOR-273527 |
| LCK | phosphorylation → unknown | ZAP70 | SIGNOR-251392 |
| LCK | phosphorylation → up-regulates activity | LAX1 | SIGNOR-273528 |
| LCK | phosphorylation → up-regulates activity | ZAP70 | SIGNOR-226628 |
| LCK | phosphorylation → unknown | IL2RB | SIGNOR-251377 |
| LCK | phosphorylation → up-regulates activity | PRKCD | SIGNOR-251384 |
| LCK | phosphorylation → up-regulates | PLCG2 | SIGNOR-91477 |
| LCK | phosphorylation → unknown | PRKCQ | SIGNOR-74574 |
| LCK | phosphorylation → down-regulates activity | PRDX2 | SIGNOR-276279 |
| LCK | phosphorylation → up-regulates | Gbeta | SIGNOR-269899 |
| LCK | phosphorylation → up-regulates activity | MUC1 | SIGNOR-247058 |
| LCK | phosphorylation → up-regulates activity | CD3E | SIGNOR-259930 |
| LCK | phosphorylation down-regulates | FOXP3 | SIGNOR-203089 |